Imerslund-Gräsbeck syndrome with developmental cataract

Sumana J. Kamath, Amruthavalli K.S., Kamalakshi G. Bhat, Pooja Kandula

Research output: Contribution to journalArticle

Abstract

An 18-year-old girl was referred to the ophthalmology department with diminution of vision in both eyes of 1-year duration. Imerslund-Gräsbeck syndrome was diagnosed. On examination, anterior polar cataract and posterior subcapsular opacification were present in the right eye and posterior subcapsular opacification was present in the left eye. The rest of the anterior segment was unremarkable in both eyes. Congenital and other systemic associations were ruled out for the lenticular opacity. In the Imerslund-Gräsbeck syndrome, cobalamin deficiency is associated with proteinuria. Low vitamin B12 levels result in high plasma homocysteine levels, which is a potential biomarker of oxidative damage and cataractogenic stressor. Screening and regular follow-up of these cases can result in early detection of cataract and improvement of the visual acuity.

Original languageEnglish
Pages (from-to)67-68
Number of pages2
JournalJCRS Online Case Reports
Volume5
Issue number4
DOIs
Publication statusPublished - 01-10-2017

Fingerprint

Cataract
Vitamin B 12
Homocysteine
Ophthalmology
Proteinuria
Visual Acuity
Biomarkers

All Science Journal Classification (ASJC) codes

  • Surgery
  • Ophthalmology

Cite this

Kamath, Sumana J. ; K.S., Amruthavalli ; Bhat, Kamalakshi G. ; Kandula, Pooja. / Imerslund-Gräsbeck syndrome with developmental cataract. In: JCRS Online Case Reports. 2017 ; Vol. 5, No. 4. pp. 67-68.
@article{e3ca2d6b238e4839aab573c54c9563bc,
title = "Imerslund-Gr{\"a}sbeck syndrome with developmental cataract",
abstract = "An 18-year-old girl was referred to the ophthalmology department with diminution of vision in both eyes of 1-year duration. Imerslund-Gr{\"a}sbeck syndrome was diagnosed. On examination, anterior polar cataract and posterior subcapsular opacification were present in the right eye and posterior subcapsular opacification was present in the left eye. The rest of the anterior segment was unremarkable in both eyes. Congenital and other systemic associations were ruled out for the lenticular opacity. In the Imerslund-Gr{\"a}sbeck syndrome, cobalamin deficiency is associated with proteinuria. Low vitamin B12 levels result in high plasma homocysteine levels, which is a potential biomarker of oxidative damage and cataractogenic stressor. Screening and regular follow-up of these cases can result in early detection of cataract and improvement of the visual acuity.",
author = "Kamath, {Sumana J.} and Amruthavalli K.S. and Bhat, {Kamalakshi G.} and Pooja Kandula",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.jcro.2017.10.001",
language = "English",
volume = "5",
pages = "67--68",
journal = "JCRS Online Case Reports",
issn = "2214-1677",
publisher = "Elsevier Inc.",
number = "4",

}

Imerslund-Gräsbeck syndrome with developmental cataract. / Kamath, Sumana J.; K.S., Amruthavalli; Bhat, Kamalakshi G.; Kandula, Pooja.

In: JCRS Online Case Reports, Vol. 5, No. 4, 01.10.2017, p. 67-68.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Imerslund-Gräsbeck syndrome with developmental cataract

AU - Kamath, Sumana J.

AU - K.S., Amruthavalli

AU - Bhat, Kamalakshi G.

AU - Kandula, Pooja

PY - 2017/10/1

Y1 - 2017/10/1

N2 - An 18-year-old girl was referred to the ophthalmology department with diminution of vision in both eyes of 1-year duration. Imerslund-Gräsbeck syndrome was diagnosed. On examination, anterior polar cataract and posterior subcapsular opacification were present in the right eye and posterior subcapsular opacification was present in the left eye. The rest of the anterior segment was unremarkable in both eyes. Congenital and other systemic associations were ruled out for the lenticular opacity. In the Imerslund-Gräsbeck syndrome, cobalamin deficiency is associated with proteinuria. Low vitamin B12 levels result in high plasma homocysteine levels, which is a potential biomarker of oxidative damage and cataractogenic stressor. Screening and regular follow-up of these cases can result in early detection of cataract and improvement of the visual acuity.

AB - An 18-year-old girl was referred to the ophthalmology department with diminution of vision in both eyes of 1-year duration. Imerslund-Gräsbeck syndrome was diagnosed. On examination, anterior polar cataract and posterior subcapsular opacification were present in the right eye and posterior subcapsular opacification was present in the left eye. The rest of the anterior segment was unremarkable in both eyes. Congenital and other systemic associations were ruled out for the lenticular opacity. In the Imerslund-Gräsbeck syndrome, cobalamin deficiency is associated with proteinuria. Low vitamin B12 levels result in high plasma homocysteine levels, which is a potential biomarker of oxidative damage and cataractogenic stressor. Screening and regular follow-up of these cases can result in early detection of cataract and improvement of the visual acuity.

UR - http://www.scopus.com/inward/record.url?scp=85032190796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032190796&partnerID=8YFLogxK

U2 - 10.1016/j.jcro.2017.10.001

DO - 10.1016/j.jcro.2017.10.001

M3 - Article

AN - SCOPUS:85032190796

VL - 5

SP - 67

EP - 68

JO - JCRS Online Case Reports

JF - JCRS Online Case Reports

SN - 2214-1677

IS - 4

ER -