Immune thrombocytopenia secondary to tuberculosis: A case and review of literature

S. F. Weber, S. Bélard, S. Rai, R. Reddy, S. Belurkar, K. Saravu

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Immune thrombocytopenia (ITP) is an auto-immune condition that results in isolated thrombocytopenia associated with possibly lethal haemorrhage. In its secondary form, ITP can be triggered by many infectious and non-infectious conditions. Secondary ITP associated with tuberculosis (TB) has rarely been described in the literature. We report on a 22-year-old patient presenting with hypermenorrhoea and petechiae due to ITP secondary to tuberculous lymphadenitis. Normalisation of thrombocytopenia was only achieved after initiation of anti-tuberculosis treatment following failure of thrombocyte substitution and immune-modulatory treatment. A search of the literature available on TB-associated ITP identified 50 cases published between 1964 and 2016.We reviewed all cases using suggested case definitions on the likelihood of association between ITP and TB. A broad spectrum of TB sites was reported to be associated with ITP, and anti-tuberculosis treatment was the most effective therapy for platelet count normalisation. Time from initiation of anti-tuberculosis treatment to platelet count recovery ranged from 2 days to 3 months. In endemic regions, TB should be considered as an underlying cause of ITP. Early diagnosis of TB and initiation of anti-tuberculosis treatment appears crucial for rapid platelet count recovery, and can reduce the risks associated with long-term immunosuppression, transfusions and the time at risk for haemorrhage.

Original languageEnglish
Pages (from-to)466-470
Number of pages5
JournalInternational Journal of Tuberculosis and Lung Disease
Volume21
Issue number4
DOIs
Publication statusPublished - 01-04-2017

Fingerprint

Idiopathic Thrombocytopenic Purpura
Tuberculosis
Platelet Count
Thrombocytopenia
Hemorrhage
Lymph Node Tuberculosis
Therapeutics
Menorrhagia
Purpura
Treatment Failure
Immunosuppression
Early Diagnosis
Blood Platelets

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

@article{0527a992bd6047198fbc8919d157a5a5,
title = "Immune thrombocytopenia secondary to tuberculosis: A case and review of literature",
abstract = "Immune thrombocytopenia (ITP) is an auto-immune condition that results in isolated thrombocytopenia associated with possibly lethal haemorrhage. In its secondary form, ITP can be triggered by many infectious and non-infectious conditions. Secondary ITP associated with tuberculosis (TB) has rarely been described in the literature. We report on a 22-year-old patient presenting with hypermenorrhoea and petechiae due to ITP secondary to tuberculous lymphadenitis. Normalisation of thrombocytopenia was only achieved after initiation of anti-tuberculosis treatment following failure of thrombocyte substitution and immune-modulatory treatment. A search of the literature available on TB-associated ITP identified 50 cases published between 1964 and 2016.We reviewed all cases using suggested case definitions on the likelihood of association between ITP and TB. A broad spectrum of TB sites was reported to be associated with ITP, and anti-tuberculosis treatment was the most effective therapy for platelet count normalisation. Time from initiation of anti-tuberculosis treatment to platelet count recovery ranged from 2 days to 3 months. In endemic regions, TB should be considered as an underlying cause of ITP. Early diagnosis of TB and initiation of anti-tuberculosis treatment appears crucial for rapid platelet count recovery, and can reduce the risks associated with long-term immunosuppression, transfusions and the time at risk for haemorrhage.",
author = "Weber, {S. F.} and S. B{\'e}lard and S. Rai and R. Reddy and S. Belurkar and K. Saravu",
year = "2017",
month = "4",
day = "1",
doi = "10.5588/ijtld.16.0515",
language = "English",
volume = "21",
pages = "466--470",
journal = "International Journal of Tuberculosis and Lung Disease",
issn = "1027-3719",
publisher = "International Union against Tubercul. and Lung Dis.",
number = "4",

}

Immune thrombocytopenia secondary to tuberculosis : A case and review of literature. / Weber, S. F.; Bélard, S.; Rai, S.; Reddy, R.; Belurkar, S.; Saravu, K.

In: International Journal of Tuberculosis and Lung Disease, Vol. 21, No. 4, 01.04.2017, p. 466-470.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Immune thrombocytopenia secondary to tuberculosis

T2 - A case and review of literature

AU - Weber, S. F.

AU - Bélard, S.

AU - Rai, S.

AU - Reddy, R.

AU - Belurkar, S.

AU - Saravu, K.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Immune thrombocytopenia (ITP) is an auto-immune condition that results in isolated thrombocytopenia associated with possibly lethal haemorrhage. In its secondary form, ITP can be triggered by many infectious and non-infectious conditions. Secondary ITP associated with tuberculosis (TB) has rarely been described in the literature. We report on a 22-year-old patient presenting with hypermenorrhoea and petechiae due to ITP secondary to tuberculous lymphadenitis. Normalisation of thrombocytopenia was only achieved after initiation of anti-tuberculosis treatment following failure of thrombocyte substitution and immune-modulatory treatment. A search of the literature available on TB-associated ITP identified 50 cases published between 1964 and 2016.We reviewed all cases using suggested case definitions on the likelihood of association between ITP and TB. A broad spectrum of TB sites was reported to be associated with ITP, and anti-tuberculosis treatment was the most effective therapy for platelet count normalisation. Time from initiation of anti-tuberculosis treatment to platelet count recovery ranged from 2 days to 3 months. In endemic regions, TB should be considered as an underlying cause of ITP. Early diagnosis of TB and initiation of anti-tuberculosis treatment appears crucial for rapid platelet count recovery, and can reduce the risks associated with long-term immunosuppression, transfusions and the time at risk for haemorrhage.

AB - Immune thrombocytopenia (ITP) is an auto-immune condition that results in isolated thrombocytopenia associated with possibly lethal haemorrhage. In its secondary form, ITP can be triggered by many infectious and non-infectious conditions. Secondary ITP associated with tuberculosis (TB) has rarely been described in the literature. We report on a 22-year-old patient presenting with hypermenorrhoea and petechiae due to ITP secondary to tuberculous lymphadenitis. Normalisation of thrombocytopenia was only achieved after initiation of anti-tuberculosis treatment following failure of thrombocyte substitution and immune-modulatory treatment. A search of the literature available on TB-associated ITP identified 50 cases published between 1964 and 2016.We reviewed all cases using suggested case definitions on the likelihood of association between ITP and TB. A broad spectrum of TB sites was reported to be associated with ITP, and anti-tuberculosis treatment was the most effective therapy for platelet count normalisation. Time from initiation of anti-tuberculosis treatment to platelet count recovery ranged from 2 days to 3 months. In endemic regions, TB should be considered as an underlying cause of ITP. Early diagnosis of TB and initiation of anti-tuberculosis treatment appears crucial for rapid platelet count recovery, and can reduce the risks associated with long-term immunosuppression, transfusions and the time at risk for haemorrhage.

UR - http://www.scopus.com/inward/record.url?scp=85015301770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015301770&partnerID=8YFLogxK

U2 - 10.5588/ijtld.16.0515

DO - 10.5588/ijtld.16.0515

M3 - Review article

AN - SCOPUS:85015301770

VL - 21

SP - 466

EP - 470

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

SN - 1027-3719

IS - 4

ER -