Immunologic response to oral polio vaccine in human immunodeficiency virus-infected and uninfected Zimbabwean children

Devasena Gnanashanmugam, Stephanie B. Troy, Georgina Musingwini, ChunHong Huang, Meira S. Halpern, Lynda Stranix-Chibanda, Avinash K. Shetty, Diana Kouiavskaia, Kusum Nathoo, Konstantin Chumakov, Yvonne A. Maldonado

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Poliovirus eradication is dependent on maintaining adequate community-wide levels of serologic protection. Many African countries with conditions that favor continued wild poliovirus propagation also have a high prevalence of pediatric human immunodeficiency virus (HIV) infection. Data are limited regarding the degree of serologic immunity conferred on HIV-infected children after immunization with oral polio vaccine (OPV). Methods: This was a cross-sectional study correlating HIV infection and neutralizing antibodies against poliovirus serotypes 1, 2, and 3 in 95 Zimbabwean children 2 months to 2 years of age, born to HIV-infected mothers, who received OPV according to the national schedule. Results: HIV-infected children had significantly lower rates of seroconversion to all 3 poliovirus serotypes than HIV-uninfected children (60%, 67%, and 47% vs. 96%, 100%, and 82%, P = 0.001, 0.0003, and 0.015 for serotypes 1, 2, and 3 in HIV-infected and uninfected children, respectively, after ≥3 OPV doses). Among poliovirus seroconverters, HIV-infected children also had significantly lower geometric mean titers against serotypes 1 and 2 than HIV-uninfected children (geometric mean titers: 198 and 317 vs. 1193 and 1056, P = 0.032 and 0.050, for serotypes 1 and 2, respectively, after ≥3 OPV doses). In addition, HIV-infected children had significantly higher levels of total IgG and significantly lower CD4% and mean weight than HIV-uninfected children. Of note, none of the HIV-infected children were receiving antiretroviral therapy, and 71% had a CD4% indicating severe immunodeficiency. Conclusions: Pediatric HIV infection is associated with a poor serologic response to OPV, which could pose an obstacle to global polio eradication.

Original languageEnglish
Pages (from-to)176-180
Number of pages5
JournalPediatric Infectious Disease Journal
Volume31
Issue number2
DOIs
Publication statusPublished - 01-02-2012
Externally publishedYes

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Poliomyelitis
Vaccines
HIV
Poliovirus
Virus Diseases
Pediatrics
HIV-2
Neutralizing Antibodies
HIV-1
Immunity
Immunization
Appointments and Schedules
Cross-Sectional Studies
Immunoglobulin G
Mothers
Serogroup
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Gnanashanmugam, D., Troy, S. B., Musingwini, G., Huang, C., Halpern, M. S., Stranix-Chibanda, L., ... Maldonado, Y. A. (2012). Immunologic response to oral polio vaccine in human immunodeficiency virus-infected and uninfected Zimbabwean children. Pediatric Infectious Disease Journal, 31(2), 176-180. https://doi.org/10.1097/INF.0b013e31823faa5f
Gnanashanmugam, Devasena ; Troy, Stephanie B. ; Musingwini, Georgina ; Huang, ChunHong ; Halpern, Meira S. ; Stranix-Chibanda, Lynda ; Shetty, Avinash K. ; Kouiavskaia, Diana ; Nathoo, Kusum ; Chumakov, Konstantin ; Maldonado, Yvonne A. / Immunologic response to oral polio vaccine in human immunodeficiency virus-infected and uninfected Zimbabwean children. In: Pediatric Infectious Disease Journal. 2012 ; Vol. 31, No. 2. pp. 176-180.
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abstract = "Background: Poliovirus eradication is dependent on maintaining adequate community-wide levels of serologic protection. Many African countries with conditions that favor continued wild poliovirus propagation also have a high prevalence of pediatric human immunodeficiency virus (HIV) infection. Data are limited regarding the degree of serologic immunity conferred on HIV-infected children after immunization with oral polio vaccine (OPV). Methods: This was a cross-sectional study correlating HIV infection and neutralizing antibodies against poliovirus serotypes 1, 2, and 3 in 95 Zimbabwean children 2 months to 2 years of age, born to HIV-infected mothers, who received OPV according to the national schedule. Results: HIV-infected children had significantly lower rates of seroconversion to all 3 poliovirus serotypes than HIV-uninfected children (60{\%}, 67{\%}, and 47{\%} vs. 96{\%}, 100{\%}, and 82{\%}, P = 0.001, 0.0003, and 0.015 for serotypes 1, 2, and 3 in HIV-infected and uninfected children, respectively, after ≥3 OPV doses). Among poliovirus seroconverters, HIV-infected children also had significantly lower geometric mean titers against serotypes 1 and 2 than HIV-uninfected children (geometric mean titers: 198 and 317 vs. 1193 and 1056, P = 0.032 and 0.050, for serotypes 1 and 2, respectively, after ≥3 OPV doses). In addition, HIV-infected children had significantly higher levels of total IgG and significantly lower CD4{\%} and mean weight than HIV-uninfected children. Of note, none of the HIV-infected children were receiving antiretroviral therapy, and 71{\%} had a CD4{\%} indicating severe immunodeficiency. Conclusions: Pediatric HIV infection is associated with a poor serologic response to OPV, which could pose an obstacle to global polio eradication.",
author = "Devasena Gnanashanmugam and Troy, {Stephanie B.} and Georgina Musingwini and ChunHong Huang and Halpern, {Meira S.} and Lynda Stranix-Chibanda and Shetty, {Avinash K.} and Diana Kouiavskaia and Kusum Nathoo and Konstantin Chumakov and Maldonado, {Yvonne A.}",
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Gnanashanmugam, D, Troy, SB, Musingwini, G, Huang, C, Halpern, MS, Stranix-Chibanda, L, Shetty, AK, Kouiavskaia, D, Nathoo, K, Chumakov, K & Maldonado, YA 2012, 'Immunologic response to oral polio vaccine in human immunodeficiency virus-infected and uninfected Zimbabwean children', Pediatric Infectious Disease Journal, vol. 31, no. 2, pp. 176-180. https://doi.org/10.1097/INF.0b013e31823faa5f

Immunologic response to oral polio vaccine in human immunodeficiency virus-infected and uninfected Zimbabwean children. / Gnanashanmugam, Devasena; Troy, Stephanie B.; Musingwini, Georgina; Huang, ChunHong; Halpern, Meira S.; Stranix-Chibanda, Lynda; Shetty, Avinash K.; Kouiavskaia, Diana; Nathoo, Kusum; Chumakov, Konstantin; Maldonado, Yvonne A.

In: Pediatric Infectious Disease Journal, Vol. 31, No. 2, 01.02.2012, p. 176-180.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Immunologic response to oral polio vaccine in human immunodeficiency virus-infected and uninfected Zimbabwean children

AU - Gnanashanmugam, Devasena

AU - Troy, Stephanie B.

AU - Musingwini, Georgina

AU - Huang, ChunHong

AU - Halpern, Meira S.

AU - Stranix-Chibanda, Lynda

AU - Shetty, Avinash K.

AU - Kouiavskaia, Diana

AU - Nathoo, Kusum

AU - Chumakov, Konstantin

AU - Maldonado, Yvonne A.

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Background: Poliovirus eradication is dependent on maintaining adequate community-wide levels of serologic protection. Many African countries with conditions that favor continued wild poliovirus propagation also have a high prevalence of pediatric human immunodeficiency virus (HIV) infection. Data are limited regarding the degree of serologic immunity conferred on HIV-infected children after immunization with oral polio vaccine (OPV). Methods: This was a cross-sectional study correlating HIV infection and neutralizing antibodies against poliovirus serotypes 1, 2, and 3 in 95 Zimbabwean children 2 months to 2 years of age, born to HIV-infected mothers, who received OPV according to the national schedule. Results: HIV-infected children had significantly lower rates of seroconversion to all 3 poliovirus serotypes than HIV-uninfected children (60%, 67%, and 47% vs. 96%, 100%, and 82%, P = 0.001, 0.0003, and 0.015 for serotypes 1, 2, and 3 in HIV-infected and uninfected children, respectively, after ≥3 OPV doses). Among poliovirus seroconverters, HIV-infected children also had significantly lower geometric mean titers against serotypes 1 and 2 than HIV-uninfected children (geometric mean titers: 198 and 317 vs. 1193 and 1056, P = 0.032 and 0.050, for serotypes 1 and 2, respectively, after ≥3 OPV doses). In addition, HIV-infected children had significantly higher levels of total IgG and significantly lower CD4% and mean weight than HIV-uninfected children. Of note, none of the HIV-infected children were receiving antiretroviral therapy, and 71% had a CD4% indicating severe immunodeficiency. Conclusions: Pediatric HIV infection is associated with a poor serologic response to OPV, which could pose an obstacle to global polio eradication.

AB - Background: Poliovirus eradication is dependent on maintaining adequate community-wide levels of serologic protection. Many African countries with conditions that favor continued wild poliovirus propagation also have a high prevalence of pediatric human immunodeficiency virus (HIV) infection. Data are limited regarding the degree of serologic immunity conferred on HIV-infected children after immunization with oral polio vaccine (OPV). Methods: This was a cross-sectional study correlating HIV infection and neutralizing antibodies against poliovirus serotypes 1, 2, and 3 in 95 Zimbabwean children 2 months to 2 years of age, born to HIV-infected mothers, who received OPV according to the national schedule. Results: HIV-infected children had significantly lower rates of seroconversion to all 3 poliovirus serotypes than HIV-uninfected children (60%, 67%, and 47% vs. 96%, 100%, and 82%, P = 0.001, 0.0003, and 0.015 for serotypes 1, 2, and 3 in HIV-infected and uninfected children, respectively, after ≥3 OPV doses). Among poliovirus seroconverters, HIV-infected children also had significantly lower geometric mean titers against serotypes 1 and 2 than HIV-uninfected children (geometric mean titers: 198 and 317 vs. 1193 and 1056, P = 0.032 and 0.050, for serotypes 1 and 2, respectively, after ≥3 OPV doses). In addition, HIV-infected children had significantly higher levels of total IgG and significantly lower CD4% and mean weight than HIV-uninfected children. Of note, none of the HIV-infected children were receiving antiretroviral therapy, and 71% had a CD4% indicating severe immunodeficiency. Conclusions: Pediatric HIV infection is associated with a poor serologic response to OPV, which could pose an obstacle to global polio eradication.

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