Immunological response to two hepatitis B vaccines administered in two different schedules

K. M. Girisha, J. R. Kamat, G. Nataraj

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives. To evaluate the antibody response to a plasma derived hepatitis B vaccine containing pre-S and S antigens and a recombinant vaccine containing only S antigen and compare the two vaccines in 0, 1, 2 and 0, 1, 6, schedules Methods. One hundred fifty nine healthy infants were randomized to receive the vaccines in two different schedules. Anti HBs titers were estimated prior to the vaccination and then one-month following the second and third doses. Results. Both the vaccines produced a high rate of seroconversion and seroprotection. The antibody response was similar with both the vaccines and the 0, 1, 6, schedule induced a significantly higher antibody level than the 0, 1, 2, schedule. Conclusion. 0, 1, 6 schedule produces a higher antibody level than 0, 1, 2 schedule though both the schedules have good seroconversion and seroprotection rates with both the vaccines.

Original languageEnglish
Pages (from-to)489-491
Number of pages3
JournalIndian Journal of Pediatrics
Volume73
Issue number6
DOIs
Publication statusPublished - 06-2006

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Hepatitis B Vaccines
Appointments and Schedules
Vaccines
Antibody Formation
Antigens
Synthetic Vaccines
Antibodies
Vaccination

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

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abstract = "Objectives. To evaluate the antibody response to a plasma derived hepatitis B vaccine containing pre-S and S antigens and a recombinant vaccine containing only S antigen and compare the two vaccines in 0, 1, 2 and 0, 1, 6, schedules Methods. One hundred fifty nine healthy infants were randomized to receive the vaccines in two different schedules. Anti HBs titers were estimated prior to the vaccination and then one-month following the second and third doses. Results. Both the vaccines produced a high rate of seroconversion and seroprotection. The antibody response was similar with both the vaccines and the 0, 1, 6, schedule induced a significantly higher antibody level than the 0, 1, 2, schedule. Conclusion. 0, 1, 6 schedule produces a higher antibody level than 0, 1, 2 schedule though both the schedules have good seroconversion and seroprotection rates with both the vaccines.",
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Immunological response to two hepatitis B vaccines administered in two different schedules. / Girisha, K. M.; Kamat, J. R.; Nataraj, G.

In: Indian Journal of Pediatrics, Vol. 73, No. 6, 06.2006, p. 489-491.

Research output: Contribution to journalArticle

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