Immunomodulatory activities of Wrightia tinctoria (Roxb.) R. Br bark extracts

P. Thabah, G. Murugananthan, N.C. Joshi, K. Nandakumar, K. Lakshman, S. Talwar

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Wrightia tinctoria (Roxb.) R.Br. (WT) has been reported to exhibit number of therapeutic uses such as astringent, stomachic, febrifuge, skin diseases and tonic in India. The objective of the present study was to investigate the immunomodulatory activity of the bark extracts of WT using delayed type hypersensitivity reaction and carbon clearance assay. Powdered dried barks of WT were extracted with petroleum ether 60 - 80°C (PEWT), alcohol (ALWT) and aqueous alcohol (AQWT) (60% water + 40% ethanol) successively. PEWT and ALWT extracts (200,400mg/kg, p.o) produced a significant increase in delayed type hypersensitivity in response to sheep red blood cells (SRBC). PEWT showed better activity than ALWT in delayed type hypersensitivity response. ALWT (200 and 400mg/kg, p.o) in dose dependent manner have shown significantly increase in the phagocytic activity. The above results reveal that ALWT possesses immunostimulant activity in carbon clearance assay whereas PEWT and ALWT showed immunomodulatory activity in delayed type hypersensitivity model.
Original languageEnglish
Pages (from-to)663-669
Number of pages7
JournalPharmacologyonline
Volume3
Publication statusPublished - 2009

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