Impact of body mass index on progression of primary immunoglobulin a nephropathy

Shankar Prasad Nagaraju, Dharshan Rangaswamy, Aswani Srinivas Mareddy, Srikanth Prasad, Sindhu Kaza, Srinivas Shenoy, Karan Saraf, Ravindra Prabhu Attur, Rajeevalochana Parthasarathy, Srinivas Kosuru, Uday Venkat Mateti, Vasudeva Guddattu, Sindhura Lakshmi Koulmane Laxminarayana

Research output: Contribution to journalArticle

Abstract

The role of obesity in the progression of primary glomerular diseases is controversial. A few studies report overweight/obesity as a risk factor for disease progression in immunoglobulin A nephropathy (IgAN), and the real impact of it still remains unclear. The aim of this study was to elucidate the effect of body mass index (BMI) on disease progression and proteinuria in patients with IgAN in Indian population. A cohort of biopsy-proven primary IgAN patients diagnosed between March 2010 and February 2015 who had a follow-up for a minimum of 12 months were included in the study. We defined two groups of patients according to the BMI value at diagnosis: non-obese group (Group N) with BMI <23 Kg/m2 and the overweight/obese group (Group O) with BMI >23 Kg/m2 as per Asia-Pacific task force criteria. Baseline characteristics were compared between the groups. The estimated glomerular filtration rate (eGFR) and urine protein-creatinine ratio (UPCR) were followed up at entry time, 6 months, 12 months, and at the end of follow-up. Outcomes studied were change in eGFR, proteinuria, and progression to end-stage renal disease. Statistical analysis was done using the Statistical Package for the Social Sciences version 15.0. Of 51 patients, 25 (49%) had BMI <23 kg/m2 (Group N) and 26 (51%) had BMI >23 kg/m2 (Group O) (P = 0.01). The baseline clinical, histopathological, and treatment characteristics of both the groups were comparable. The BMI at the time of diagnosis did not have any significant effect on eGFR (P = 0.41) or proteinuria (P = 0.99) at presentation. At the end of follow-up, both the groups had a similar reduction of proteinuria (UPCR) (P = 0.46) and eGFR (P = 0.20). Two patients in each group have reached chronic kidney disease Stage 5. In the present study, BMI at presentation did not have any impact on eGFR or proteinuria, either at diagnosis or at follow-up. It needs further large multicenter randomized control studies to see the effect of BMI on progression of IgAN.

Original languageEnglish
Pages (from-to)318-325
Number of pages8
JournalSaudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Volume29
Issue number2
DOIs
Publication statusPublished - 01-03-2018

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Immunoglobulins
IGA Glomerulonephritis
Body Mass Index
Glomerular Filtration Rate
Proteinuria
Disease Progression
Creatinine
Obesity
Urine
Social Sciences
Advisory Committees
Chronic Renal Insufficiency
Chronic Kidney Failure
Proteins
Biopsy
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Nagaraju, Shankar Prasad ; Rangaswamy, Dharshan ; Mareddy, Aswani Srinivas ; Prasad, Srikanth ; Kaza, Sindhu ; Shenoy, Srinivas ; Saraf, Karan ; Attur, Ravindra Prabhu ; Parthasarathy, Rajeevalochana ; Kosuru, Srinivas ; Mateti, Uday Venkat ; Guddattu, Vasudeva ; Koulmane Laxminarayana, Sindhura Lakshmi. / Impact of body mass index on progression of primary immunoglobulin a nephropathy. In: Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2018 ; Vol. 29, No. 2. pp. 318-325.
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Impact of body mass index on progression of primary immunoglobulin a nephropathy. / Nagaraju, Shankar Prasad; Rangaswamy, Dharshan; Mareddy, Aswani Srinivas; Prasad, Srikanth; Kaza, Sindhu; Shenoy, Srinivas; Saraf, Karan; Attur, Ravindra Prabhu; Parthasarathy, Rajeevalochana; Kosuru, Srinivas; Mateti, Uday Venkat; Guddattu, Vasudeva; Koulmane Laxminarayana, Sindhura Lakshmi.

In: Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, Vol. 29, No. 2, 01.03.2018, p. 318-325.

Research output: Contribution to journalArticle

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T1 - Impact of body mass index on progression of primary immunoglobulin a nephropathy

AU - Nagaraju, Shankar Prasad

AU - Rangaswamy, Dharshan

AU - Mareddy, Aswani Srinivas

AU - Prasad, Srikanth

AU - Kaza, Sindhu

AU - Shenoy, Srinivas

AU - Saraf, Karan

AU - Attur, Ravindra Prabhu

AU - Parthasarathy, Rajeevalochana

AU - Kosuru, Srinivas

AU - Mateti, Uday Venkat

AU - Guddattu, Vasudeva

AU - Koulmane Laxminarayana, Sindhura Lakshmi

PY - 2018/3/1

Y1 - 2018/3/1

N2 - The role of obesity in the progression of primary glomerular diseases is controversial. A few studies report overweight/obesity as a risk factor for disease progression in immunoglobulin A nephropathy (IgAN), and the real impact of it still remains unclear. The aim of this study was to elucidate the effect of body mass index (BMI) on disease progression and proteinuria in patients with IgAN in Indian population. A cohort of biopsy-proven primary IgAN patients diagnosed between March 2010 and February 2015 who had a follow-up for a minimum of 12 months were included in the study. We defined two groups of patients according to the BMI value at diagnosis: non-obese group (Group N) with BMI <23 Kg/m2 and the overweight/obese group (Group O) with BMI >23 Kg/m2 as per Asia-Pacific task force criteria. Baseline characteristics were compared between the groups. The estimated glomerular filtration rate (eGFR) and urine protein-creatinine ratio (UPCR) were followed up at entry time, 6 months, 12 months, and at the end of follow-up. Outcomes studied were change in eGFR, proteinuria, and progression to end-stage renal disease. Statistical analysis was done using the Statistical Package for the Social Sciences version 15.0. Of 51 patients, 25 (49%) had BMI <23 kg/m2 (Group N) and 26 (51%) had BMI >23 kg/m2 (Group O) (P = 0.01). The baseline clinical, histopathological, and treatment characteristics of both the groups were comparable. The BMI at the time of diagnosis did not have any significant effect on eGFR (P = 0.41) or proteinuria (P = 0.99) at presentation. At the end of follow-up, both the groups had a similar reduction of proteinuria (UPCR) (P = 0.46) and eGFR (P = 0.20). Two patients in each group have reached chronic kidney disease Stage 5. In the present study, BMI at presentation did not have any impact on eGFR or proteinuria, either at diagnosis or at follow-up. It needs further large multicenter randomized control studies to see the effect of BMI on progression of IgAN.

AB - The role of obesity in the progression of primary glomerular diseases is controversial. A few studies report overweight/obesity as a risk factor for disease progression in immunoglobulin A nephropathy (IgAN), and the real impact of it still remains unclear. The aim of this study was to elucidate the effect of body mass index (BMI) on disease progression and proteinuria in patients with IgAN in Indian population. A cohort of biopsy-proven primary IgAN patients diagnosed between March 2010 and February 2015 who had a follow-up for a minimum of 12 months were included in the study. We defined two groups of patients according to the BMI value at diagnosis: non-obese group (Group N) with BMI <23 Kg/m2 and the overweight/obese group (Group O) with BMI >23 Kg/m2 as per Asia-Pacific task force criteria. Baseline characteristics were compared between the groups. The estimated glomerular filtration rate (eGFR) and urine protein-creatinine ratio (UPCR) were followed up at entry time, 6 months, 12 months, and at the end of follow-up. Outcomes studied were change in eGFR, proteinuria, and progression to end-stage renal disease. Statistical analysis was done using the Statistical Package for the Social Sciences version 15.0. Of 51 patients, 25 (49%) had BMI <23 kg/m2 (Group N) and 26 (51%) had BMI >23 kg/m2 (Group O) (P = 0.01). The baseline clinical, histopathological, and treatment characteristics of both the groups were comparable. The BMI at the time of diagnosis did not have any significant effect on eGFR (P = 0.41) or proteinuria (P = 0.99) at presentation. At the end of follow-up, both the groups had a similar reduction of proteinuria (UPCR) (P = 0.46) and eGFR (P = 0.20). Two patients in each group have reached chronic kidney disease Stage 5. In the present study, BMI at presentation did not have any impact on eGFR or proteinuria, either at diagnosis or at follow-up. It needs further large multicenter randomized control studies to see the effect of BMI on progression of IgAN.

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