Impaired hypothalamic-pituitary-gonadal axis function in men with diabetes mellitus

M. Maneesh, H. Jayalakshmi, T. A. Singh, Amit Chakrabarti

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In view of association of diabetes mellitus and male infertility, present study was designed to investigate the functional status of hypothalamic pituitary gonadal (HPG) axis in diabetic men. Thirty-five diabetic men (BMI 22.24 ± 0.21) in the age group 20-40 (30.6 ± 4.7) years were selected. Twenty-five healthy men (BMI 23.85 ± 0.25), in the same age group (29.5 ± 4.8) served as control. Blood samples were collected for hormonal and biochemical estimations. Diabetic men had significantly low serum testosterone with low LH and FSH, hypercholesterolemia, hypertriglyceridemia, hypoalbuminemia and increased oxidative stress. Low serum testosterone in diabetic men was accompanied by low LH and FSH; the inability of the pituitary gland to respond appropriately to a decline in testosterone implying central effect of high serum glucose on the interaction between the nervous and endocrine system. Nutritional deficiency, increased oxidative stress and increased aromatase activity due to excessive body fat might have also contributed to low serum testosterone.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalIndian Journal of Clinical Biochemistry
Volume21
Issue number1
DOIs
Publication statusPublished - 20-03-2006
Externally publishedYes

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Medical problems
Testosterone
Diabetes Mellitus
Oxidative stress
Serum
Oxidative Stress
Age Groups
Aromatase
Hypoalbuminemia
Endocrine System
Hypertriglyceridemia
Male Infertility
Pituitary Gland
Hypercholesterolemia
Blood
Malnutrition
Fats
Nervous System
Association reactions
Adipose Tissue

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Maneesh, M. ; Jayalakshmi, H. ; Singh, T. A. ; Chakrabarti, Amit. / Impaired hypothalamic-pituitary-gonadal axis function in men with diabetes mellitus. In: Indian Journal of Clinical Biochemistry. 2006 ; Vol. 21, No. 1. pp. 165-168.
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Impaired hypothalamic-pituitary-gonadal axis function in men with diabetes mellitus. / Maneesh, M.; Jayalakshmi, H.; Singh, T. A.; Chakrabarti, Amit.

In: Indian Journal of Clinical Biochemistry, Vol. 21, No. 1, 20.03.2006, p. 165-168.

Research output: Contribution to journalArticle

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