Impaired wound healing due to Cyclophosphamide (CLP) alleviated by supplemental Ginkgo biloba (GB)

K. L. Bairy, S. B. Ganesh, M. S. Adiga, A. Shalini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To evaluate whether the extract of Ginkgo biloba (GB) could reverse the healing suppressant effect of Cyclophosphamide(CLP). Methods: The wound healing effects of CLP (12.6 mg/kg/ IP single dose on 3'd post wounding day) and GB (50 mg/kg IP) daily were tested on dead space and excision wound models in male rats. Results: CLP has significantly (p<0.05) reduced and GB has significantly (p<0.05) increased the breaking strength and hydroxyproline content of granulation tissue in dead space wounds. GB has significantly (p<0.01) reversed the suppressant effect of CLP. In case of excision wounds there was no change in wound contraction and epithelization period by CLP, GB or GB+CLP when compared to control. Conclusion: The healing suppressant effect of CLP was reversed by co-administration of GB. This effect of GB may due to its antioxidant property.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalJournal of Natural Remedies
Volume6
Issue number1
Publication statusPublished - 01-01-2006

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Ginkgo biloba
Wound Healing
Cyclophosphamide
Wounds and Injuries
Granulation Tissue
Hydroxyproline
Antioxidants

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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abstract = "Objective: To evaluate whether the extract of Ginkgo biloba (GB) could reverse the healing suppressant effect of Cyclophosphamide(CLP). Methods: The wound healing effects of CLP (12.6 mg/kg/ IP single dose on 3'd post wounding day) and GB (50 mg/kg IP) daily were tested on dead space and excision wound models in male rats. Results: CLP has significantly (p<0.05) reduced and GB has significantly (p<0.05) increased the breaking strength and hydroxyproline content of granulation tissue in dead space wounds. GB has significantly (p<0.01) reversed the suppressant effect of CLP. In case of excision wounds there was no change in wound contraction and epithelization period by CLP, GB or GB+CLP when compared to control. Conclusion: The healing suppressant effect of CLP was reversed by co-administration of GB. This effect of GB may due to its antioxidant property.",
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Impaired wound healing due to Cyclophosphamide (CLP) alleviated by supplemental Ginkgo biloba (GB). / Bairy, K. L.; Ganesh, S. B.; Adiga, M. S.; Shalini, A.

In: Journal of Natural Remedies, Vol. 6, No. 1, 01.01.2006, p. 31-34.

Research output: Contribution to journalArticle

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T1 - Impaired wound healing due to Cyclophosphamide (CLP) alleviated by supplemental Ginkgo biloba (GB)

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AU - Ganesh, S. B.

AU - Adiga, M. S.

AU - Shalini, A.

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AB - Objective: To evaluate whether the extract of Ginkgo biloba (GB) could reverse the healing suppressant effect of Cyclophosphamide(CLP). Methods: The wound healing effects of CLP (12.6 mg/kg/ IP single dose on 3'd post wounding day) and GB (50 mg/kg IP) daily were tested on dead space and excision wound models in male rats. Results: CLP has significantly (p<0.05) reduced and GB has significantly (p<0.05) increased the breaking strength and hydroxyproline content of granulation tissue in dead space wounds. GB has significantly (p<0.01) reversed the suppressant effect of CLP. In case of excision wounds there was no change in wound contraction and epithelization period by CLP, GB or GB+CLP when compared to control. Conclusion: The healing suppressant effect of CLP was reversed by co-administration of GB. This effect of GB may due to its antioxidant property.

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