Implantable drug delivery systems for Centchroman

B. D. Shenoy, N. Udupa, Nagarajkumari

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Subdermal implantable films of Centchroman were prepared using Poly-E-Caprolactone and Cellulose polymers. They were evaluated for physico-chemical characteristics, in vitro drug release profiles in phosphate buffered saline (pH 7.4), stability on storage at room temperature, 37°and 82.5% relative humidity and light exposure. In vivo anti-fertility activity of Poly-E-Caprolactone film was evaluated in female albino rats by implanting the film in the flank region. It was evident from this study, that, Poly-E-Caprolactone film was more promising for the development of a bioerodable, long acting contraceptive formulation.

Original languageEnglish
Pages (from-to)246-250
Number of pages5
JournalIndian Journal of Pharmaceutical Sciences
Volume59
Issue number5
Publication statusPublished - 09-1997

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All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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