In vitro and in vivo preparation evaluations of bleomycin implants and microspheres prepared with DL-poly (lactide-co-glycolide)

R. D'Souza, N. Udupa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this investigation, poly(lactide-co-glycolide) (PLGA) gel implants and microspheric depot systems of bleomycin (BLM) were formulated and evaluated in vivo in mice bearing transplantable solid tumor (fibrosarcoma). The pharmacodynamic studies showed that both the formulations retarded tumor growth significantly (p < 0.05) when compared to the control animals (without any drug treatment). Preliminary pharmacokinetic studies illustrated controlled release of the drug into the systemic circulation to elicit the anti-neoplastic action. The gel implants showed better release characteristics and greater pharmacodynamic action when compared to the microspheres, thus demonstrating the feasibility of employing biodegradable depot polymer gel matrix for chronic cancer therapy.

Original languageEnglish
Pages (from-to)175-184
Number of pages10
JournalDrug Development and Industrial Pharmacy
Volume32
Issue number2
DOIs
Publication statusPublished - 2006

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Polyglactin 910
Bleomycin
Microspheres
Pharmacodynamics
Gels
Tumors
Bearings (structural)
Drug therapy
Neoplasms
Biodegradable polymers
Pharmacokinetics
Fibrosarcoma
Polymers
Animals
Growth
Pharmaceutical Preparations
In Vitro Techniques
Therapeutics

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology
  • Molecular Medicine

Cite this

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