In vitro antifungal effect of mouth rinses containing chlorhexidine and thymol

Ashish Shrestha, Jyotsna Rimal, Ashwini Rao, Peter Simon Sequeira, Dolar Doshi, Gopal Krishna Bhat

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/purpose: In this in vitro study, we assessed the antifungal effect of mouth rinses containing chlorhexidine and thymol. Materials and methods: The fungistatic activities of chlorhexidine- and thymol-containing mouth rinses were assessed by means of the minimum inhibitory concentration (MIC) and the fungicidal activity was determined by a time-kill assay. Results: The chlorhexidine-containing mouthwash was able to kill all strains of Candida albicans and Candida tropicalis in shorter times compared to the thymol-containing mouthwash. Hexidine showed an MIC of 1:32 for both Candida species, whereas Listerine respectively showed MICs of 1:8 and 1:16 for C. albicans and C. tropicalis. Conclusions: Antimicrobial agents used in the study had good in vitro activity against the two Candida species. Mouth rinses containing chlorhexidine showed superior antifungal and fungicidal activities compared to the thymol-containing mouth rinse. Both antimicrobial agents may be suggested for use as topical antifungal agents.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalJournal of Dental Sciences
Volume6
Issue number1
DOIs
Publication statusPublished - 2011

Fingerprint

Mouth
Mouthwashes
Candida tropicalis
Thymol
Chlorhexidine
Microbial Sensitivity Tests
Anti-Infective Agents
Candida albicans
Candida
Antifungal Agents
In Vitro Techniques
thymol drug combination chlorhexidine

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Shrestha, Ashish ; Rimal, Jyotsna ; Rao, Ashwini ; Sequeira, Peter Simon ; Doshi, Dolar ; Bhat, Gopal Krishna. / In vitro antifungal effect of mouth rinses containing chlorhexidine and thymol. In: Journal of Dental Sciences. 2011 ; Vol. 6, No. 1. pp. 1-5.
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In vitro antifungal effect of mouth rinses containing chlorhexidine and thymol. / Shrestha, Ashish; Rimal, Jyotsna; Rao, Ashwini; Sequeira, Peter Simon; Doshi, Dolar; Bhat, Gopal Krishna.

In: Journal of Dental Sciences, Vol. 6, No. 1, 2011, p. 1-5.

Research output: Contribution to journalArticle

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AU - Shrestha, Ashish

AU - Rimal, Jyotsna

AU - Rao, Ashwini

AU - Sequeira, Peter Simon

AU - Doshi, Dolar

AU - Bhat, Gopal Krishna

PY - 2011

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