@article{fc06e6bc536b4dea8c316177424b0069,
title = "In vitro antioxidant studies of Sphaeranthus indicus (Linn)",
abstract = "The free radical scavenging potential of the plant S.indicus was studied by using different antioxidant models of screening. The ethanolic extract at 1000 μg/ml showed maximum scavenging of the radical cation, 2,2-azinobis-(3- ethylbenzothiazoline-6-sulphonate) (ABTS) observed upto 41.99 % followed by the scavenging of the stable radical 1,1-diphenyl, 2-picryl hydrazyl (DPPH) (33.27 %), superoxide dismutase (25.14 %) and nitric oxide radical (22.36 %) at the same concentration. However, the extract showed only moderate scavenging activity of iron chelation (14.2 %). Total antioxidant capacity of the extract was found to be 160.85 nmol/g ascorbic acid. The results justify the therapeutic applications of the plant in the indigenous system of medicine, augmenting its therapeutic value.",
author = "A. Shirwaikar and K.S. Prabhu and I.S.R. Punitha",
note = "Cited By :62 Export Date: 10 November 2017 CODEN: IJEBA Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal 576 104, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: nitric oxide, 10102-43-9; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; superoxide, 11062-77-4; Antioxidants; Nitric Oxide, 10102-43-9; Plant Extracts; Superoxide Dismutase, EC 1.15.1.1; Superoxides, 11062-77-4 References: Cross, C.E., Oxygen radicals and human disease (1987) Annal Int Med, 107, p. 526; Marx, J.L., Oxygen free radicals linked to many diseases (1987) Science, 235, p. 529; Ajay Arora, S.R.K., Srivastava, G.C., Oxidative stress and antioxidative system in plants (2002) Curr Sci, 82, p. 1227; Geesin, J.G., Gordon, J.S., Berg, R.A., Retinoids affect collagen synthesis through inhibition of ascorbate- induced lipid peroxidation in cultured human dermal fibroblasts (1990) Arch Biochem Biophys, 278, p. 352; Warrier, P.K., Nambiar, V.P.K., Raman Kutty, C., (2004) Indian Medicinal Plants, 1, p. 180. , Orient Longman, Hyderabad, India; Kokate, C.K., (1986) Practical pharmacognosy, p. 15. , 1st ed, Vallabh Prakashan, New Delhi, India; Yoganarasimhan, S.N., (2000) Medicinal plants of India-Tamil Nadu, 2, p. 512. , Cyber Media, Bangalore, India; Nadkarni, A.K., (2000) Indian materia medica, 1, p. 113. , Popular Prakashan Ltd, Mumbai, India; Shirwaikar Annie, K.R., Dinesh, K., In vitro antioxidant studies of Annona Squamosa (2004) Indian J Exp Biol, 142, p. 803; Sreejayan, N., Rao, M.N.A., Free radical scavenging activity of curcuminoids (1996) Drug Res, 46, p. 169; Sanchez-Moreno, C., Methods used to evaluate the free radical scavenging activity in foods and biological systems (2002) Food Sci Tech Int, 8, p. 122; Henry, L.E.A., Halliwell, B., Hall, D.O., The superoxide dismutase activity of various photosynthetic organisms measured by a new and a rapid assay technique (1976) FEBS Lett, 66, p. 303; Sreejayan, N., Rao, M.N.A., Nitric oxide scavenging by curcuminoids (1997) J Pharm Pharmacol, 49, p. 105; Annie, S., Somashekar, A.P., Antiinflammatory activity and free radical scavenging studies of Aristolochia bracteolata Lam (2003) Indian J Pharm Sci, 65, p. 68; Green, L.C., Wagner, D.A., Glogowski, J., Skipper, P.L., Wishnok, J.S., Tannenbaum, S.R., Analysis of nitrate and 15N in biological fluids (1982) Anal Biochem, 126, p. 131; Marcocci, L., Maguire, J.J., Droy- Lefaix, M.T., Packer, L., The nitric oxide scavenging property of Ginko biloba extract EGB 761 (1994) Biochem Biophys Res Commun, 201, p. 748; Benzie, I.F.F., Strain, J.T., The ferric reducing ability of pLASMA (FRAP) as a measure of {"}antioxidant power{"}: The FRAP assay (1996) Anal Biochem, 239, p. 70; Benzie, I.F.F., Szeto, Y.T., Total antioxidant capacity of Teas by the Ferric Reducing/ antioxidant power assay (1999) J Agric Food Chem, 47, p. 633; Annie, S., Govindrajan, R., Rastogi, S., Vijaykumar, M., Rawat, A.K.S., ehlotra, S.M., Pushpangadan, P., Studies on the Antioxidant activities of Desmodium gangeticum (2003) Biol Pharm Bull, 26, p. 1424; Youdim, K.A., Joseph, J.A., A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: A multiplicity of effects (2001) Free Rad Biol Med, 30, p. 583; Rice- Evans, C., Miller, N.J., Factors influencing the antioxidant activity determined by the ABTS.+ radical cation assay (1997) Free Rad Res, 26, p. 195; Blois, M.S., Antioxidant determinations by the use of stable free radical (1958) Nature, 26, p. 1199; Kamalakkannan N & Stanley Mainzen Prince P, Effect of Aegle marmelos fruit extract on tissue antioxidants in streptozotocin diabetic rats, Indian J Exp Biol, 41 (2003) 1288; Ray, G., Akhtar Husain, S., Oxidents, antioxidants and carcinogenesis (2002) Indian J Exp Biol, 40, p. 1214; Ialenti, A., Moncada, S., Di Rosa, M., Modulation of adjuvant arthritis by endogenous nitric oxide (1993) Brit J Pharmacol, 110, p. 701; Marcocci, L., Packer, L., Droy-Lefaiz, M.T., Sekaki, A., Gardes- Albert, M., Antioxidant action of Ginko biloba extract Egb 761 (1994) Meth Enzymol, 234, p. 462; Sanchez, M.C., Methods used to evaluate the free radical scavenging activity in foods and biological systems (2002) Food- Sci Tech Int, 8, p. 122",
year = "2006",
language = "English",
volume = "44",
pages = "993--996",
journal = "Journal of scientific & industrial research. C. Biological sciences",
issn = "0019-5189",
publisher = "National Institute of Science Communication",
number = "12",
}