4 Citations (Scopus)

Abstract

Context: Scaffold if suitably modified could be used as a drug delivery system. Objective: To develop chitosan scaffold as a delivery system for delivering curcumin in wound-healing application. Materials and methods: Chitosan-curcumin microcomplex particles were prepared, and the effect of drug-polymer ratio (DPR) and homogenisation speed (HS) was studied using a two-level full-factorial design. Chitosan scaffold was prepared and incorporated with curcumin microcomplexes to obtain a chitosan scaffold-containing chitosan-curcumin microcomplex (CS-CCM). Antimicrobial property of the CS-CCM against Escherichia coli was studied. The cytotoxicity of CS-CCM was studied by assessing the cell viability by MTT assay. Results and discussion: DPR had a significant effect (p ≤ 0.05) on the drug content. CS-CCM was able to inhibit the growth of E. coli considerably. The MTT results showed that CS-CCM is non-cytotoxic and supports cell proliferation. Conclusion: CS-CCM due to its biocompatibility and antimicrobial property could be further evaluated for potential application in wound healing.

Original languageEnglish
Pages (from-to)364-371
Number of pages8
JournalJournal of Microencapsulation
Volume32
Issue number4
DOIs
Publication statusPublished - 19-05-2015

Fingerprint

Curcumin
Chitosan
biocompatibility
Biocompatibility
Scaffolds
drugs
wound healing
delivery
factorial design
polymers
homogenizing
Escherichia
viability
In Vitro Techniques
Wound Healing
Escherichia coli
Polymers
Pharmaceutical Preparations
Cell proliferation
Drug Delivery Systems

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry

Cite this

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title = "In vitro biocompatibility and release of curcumin from curcumin microcomplex-loaded chitosan scaffold",
abstract = "Context: Scaffold if suitably modified could be used as a drug delivery system. Objective: To develop chitosan scaffold as a delivery system for delivering curcumin in wound-healing application. Materials and methods: Chitosan-curcumin microcomplex particles were prepared, and the effect of drug-polymer ratio (DPR) and homogenisation speed (HS) was studied using a two-level full-factorial design. Chitosan scaffold was prepared and incorporated with curcumin microcomplexes to obtain a chitosan scaffold-containing chitosan-curcumin microcomplex (CS-CCM). Antimicrobial property of the CS-CCM against Escherichia coli was studied. The cytotoxicity of CS-CCM was studied by assessing the cell viability by MTT assay. Results and discussion: DPR had a significant effect (p ≤ 0.05) on the drug content. CS-CCM was able to inhibit the growth of E. coli considerably. The MTT results showed that CS-CCM is non-cytotoxic and supports cell proliferation. Conclusion: CS-CCM due to its biocompatibility and antimicrobial property could be further evaluated for potential application in wound healing.",
author = "Muthukumar Amirthalingam and Narayanan Kasinathan and Srinivas Mutalik and Nayanabhirama Udupa",
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In vitro biocompatibility and release of curcumin from curcumin microcomplex-loaded chitosan scaffold. / Amirthalingam, Muthukumar; Kasinathan, Narayanan; Mutalik, Srinivas; Udupa, Nayanabhirama.

In: Journal of Microencapsulation, Vol. 32, No. 4, 19.05.2015, p. 364-371.

Research output: Contribution to journalArticle

TY - JOUR

T1 - In vitro biocompatibility and release of curcumin from curcumin microcomplex-loaded chitosan scaffold

AU - Amirthalingam, Muthukumar

AU - Kasinathan, Narayanan

AU - Mutalik, Srinivas

AU - Udupa, Nayanabhirama

PY - 2015/5/19

Y1 - 2015/5/19

N2 - Context: Scaffold if suitably modified could be used as a drug delivery system. Objective: To develop chitosan scaffold as a delivery system for delivering curcumin in wound-healing application. Materials and methods: Chitosan-curcumin microcomplex particles were prepared, and the effect of drug-polymer ratio (DPR) and homogenisation speed (HS) was studied using a two-level full-factorial design. Chitosan scaffold was prepared and incorporated with curcumin microcomplexes to obtain a chitosan scaffold-containing chitosan-curcumin microcomplex (CS-CCM). Antimicrobial property of the CS-CCM against Escherichia coli was studied. The cytotoxicity of CS-CCM was studied by assessing the cell viability by MTT assay. Results and discussion: DPR had a significant effect (p ≤ 0.05) on the drug content. CS-CCM was able to inhibit the growth of E. coli considerably. The MTT results showed that CS-CCM is non-cytotoxic and supports cell proliferation. Conclusion: CS-CCM due to its biocompatibility and antimicrobial property could be further evaluated for potential application in wound healing.

AB - Context: Scaffold if suitably modified could be used as a drug delivery system. Objective: To develop chitosan scaffold as a delivery system for delivering curcumin in wound-healing application. Materials and methods: Chitosan-curcumin microcomplex particles were prepared, and the effect of drug-polymer ratio (DPR) and homogenisation speed (HS) was studied using a two-level full-factorial design. Chitosan scaffold was prepared and incorporated with curcumin microcomplexes to obtain a chitosan scaffold-containing chitosan-curcumin microcomplex (CS-CCM). Antimicrobial property of the CS-CCM against Escherichia coli was studied. The cytotoxicity of CS-CCM was studied by assessing the cell viability by MTT assay. Results and discussion: DPR had a significant effect (p ≤ 0.05) on the drug content. CS-CCM was able to inhibit the growth of E. coli considerably. The MTT results showed that CS-CCM is non-cytotoxic and supports cell proliferation. Conclusion: CS-CCM due to its biocompatibility and antimicrobial property could be further evaluated for potential application in wound healing.

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