In vitro characterization of methotrexate-loaded poly(lactic acid) microspheres of different molecular weights

U.V. Singh, N. Udupa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Methotrexate-loaded poly(lactic acid) (PLA) microspheres were prepared from three different molecular weight PLAs using the emulsification-solvent evaporation method. The in vitro drug release could be controlled for up to 2 to 3 weeks. The release of the drug was dependent on the molecular weight of the polymer, the fastest release being from microspheres prepared with the lowest molecular weight PLA. This technique allows control of drug release with a single biodegradable homopolymer.

Original languageEnglish
Pages (from-to)57-61
Number of pages5
JournalDrug Delivery: Journal of Delivery and Targeting of Therapeutic Agents
Volume5
Issue number1
Publication statusPublished - 01-1998

Fingerprint

Microspheres
Methotrexate
Molecular Weight
Polymers
In Vitro Techniques
poly(lactic acid)
Drug Liberation

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

@article{27ed5dd1b3b64460910e9b14d039e835,
title = "In vitro characterization of methotrexate-loaded poly(lactic acid) microspheres of different molecular weights",
abstract = "Methotrexate-loaded poly(lactic acid) (PLA) microspheres were prepared from three different molecular weight PLAs using the emulsification-solvent evaporation method. The in vitro drug release could be controlled for up to 2 to 3 weeks. The release of the drug was dependent on the molecular weight of the polymer, the fastest release being from microspheres prepared with the lowest molecular weight PLA. This technique allows control of drug release with a single biodegradable homopolymer.",
author = "U.V. Singh and N. Udupa",
note = "cited By 2",
year = "1998",
month = "1",
language = "English",
volume = "5",
pages = "57--61",
journal = "Drug Delivery",
issn = "1071-7544",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - In vitro characterization of methotrexate-loaded poly(lactic acid) microspheres of different molecular weights

AU - Singh, U.V.

AU - Udupa, N.

N1 - cited By 2

PY - 1998/1

Y1 - 1998/1

N2 - Methotrexate-loaded poly(lactic acid) (PLA) microspheres were prepared from three different molecular weight PLAs using the emulsification-solvent evaporation method. The in vitro drug release could be controlled for up to 2 to 3 weeks. The release of the drug was dependent on the molecular weight of the polymer, the fastest release being from microspheres prepared with the lowest molecular weight PLA. This technique allows control of drug release with a single biodegradable homopolymer.

AB - Methotrexate-loaded poly(lactic acid) (PLA) microspheres were prepared from three different molecular weight PLAs using the emulsification-solvent evaporation method. The in vitro drug release could be controlled for up to 2 to 3 weeks. The release of the drug was dependent on the molecular weight of the polymer, the fastest release being from microspheres prepared with the lowest molecular weight PLA. This technique allows control of drug release with a single biodegradable homopolymer.

UR - http://www.scopus.com/inward/record.url?scp=0031967770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031967770&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031967770

VL - 5

SP - 57

EP - 61

JO - Drug Delivery

JF - Drug Delivery

SN - 1071-7544

IS - 1

ER -