In vitro characterization of methotrexate-loaded poly(lactic acid) microspheres of different molecular weights

U.V. Singh, N. Udupa

Research output: Contribution to journalArticle

2 Citations (Scopus)


Methotrexate-loaded poly(lactic acid) (PLA) microspheres were prepared from three different molecular weight PLAs using the emulsification-solvent evaporation method. The in vitro drug release could be controlled for up to 2 to 3 weeks. The release of the drug was dependent on the molecular weight of the polymer, the fastest release being from microspheres prepared with the lowest molecular weight PLA. This technique allows control of drug release with a single biodegradable homopolymer.

Original languageEnglish
Pages (from-to)57-61
Number of pages5
JournalDrug Delivery: Journal of Delivery and Targeting of Therapeutic Agents
Issue number1
Publication statusPublished - 01-1998


All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this