In vitro cytotoxicity activity of chrysin, morin and resveratrol against MCF-7 breast cancer cell lines

Arlene Thomas, Niraja Ranadive, Harisha Nayak, Sneha Surendran, Madhavan Nampoothiri, Jayesh Mudgal, Yogendra Nayak

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Pathology of cancer involves abnormal cell growth and metastasis of abnormally grown cells to other systems of body different form their origin. These mass of abnormal cell growth are termed as neoplasm or tumour. Alarming prevalence of cancer states that diagnosis of cancer is crucial in the survival of patients. Early diagnosis and adequate treatment helps in controlling the prognosis of disease. The prevalence witnessed majority of males getting affected by prostate cancer around a 43% and women diagnosed with breast cancer around a 41%. By understanding the magnitude getting affected by breast cancer, we performed tests on the breast cancer cell lines to provide with more novel drug treatments for breast cancer. Cytotoxic activity of flavonoids which includes morin and chrysin, and resveratrol, a natural polyphenol was checked individually on MCF7 breast cancer cell lines through MTT assay and the data was analyzed which could lead to new novel breast cancer treatments.

Original languageEnglish
Pages (from-to)1633-1637
Number of pages5
JournalBiosciences Biotechnology Research Asia
Volume13
Issue number3
DOIs
Publication statusPublished - 01-09-2016

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resveratrol
breast neoplasms
cytotoxicity
cell lines
Breast Neoplasms
Cell Line
neoplasms
Neoplasms
cell growth
early diagnosis
Polyphenols
prostatic neoplasms
Growth
Flavonoids
metastasis
prognosis
drug therapy
neoplasm cells
In Vitro Techniques
morin

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Agronomy and Crop Science
  • Drug Discovery

Cite this

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title = "In vitro cytotoxicity activity of chrysin, morin and resveratrol against MCF-7 breast cancer cell lines",
abstract = "Pathology of cancer involves abnormal cell growth and metastasis of abnormally grown cells to other systems of body different form their origin. These mass of abnormal cell growth are termed as neoplasm or tumour. Alarming prevalence of cancer states that diagnosis of cancer is crucial in the survival of patients. Early diagnosis and adequate treatment helps in controlling the prognosis of disease. The prevalence witnessed majority of males getting affected by prostate cancer around a 43{\%} and women diagnosed with breast cancer around a 41{\%}. By understanding the magnitude getting affected by breast cancer, we performed tests on the breast cancer cell lines to provide with more novel drug treatments for breast cancer. Cytotoxic activity of flavonoids which includes morin and chrysin, and resveratrol, a natural polyphenol was checked individually on MCF7 breast cancer cell lines through MTT assay and the data was analyzed which could lead to new novel breast cancer treatments.",
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In vitro cytotoxicity activity of chrysin, morin and resveratrol against MCF-7 breast cancer cell lines. / Thomas, Arlene; Ranadive, Niraja; Nayak, Harisha; Surendran, Sneha; Nampoothiri, Madhavan; Mudgal, Jayesh; Nayak, Yogendra.

In: Biosciences Biotechnology Research Asia, Vol. 13, No. 3, 01.09.2016, p. 1633-1637.

Research output: Contribution to journalArticle

TY - JOUR

T1 - In vitro cytotoxicity activity of chrysin, morin and resveratrol against MCF-7 breast cancer cell lines

AU - Thomas, Arlene

AU - Ranadive, Niraja

AU - Nayak, Harisha

AU - Surendran, Sneha

AU - Nampoothiri, Madhavan

AU - Mudgal, Jayesh

AU - Nayak, Yogendra

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