In vivo radioprotection by ocimum flavonoids: Survival

P. Uma Devi, A. Ganasoundari, B. S.S. Rao, K. K. Srinivasan

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

Two flavonoids, orientin and vicenin, isolated from the leaves of the Indian plant Ocimum sanctum were tested for their radioprotective effect in mice. Both compounds provided protection against death from gastrointestinal syndrome as well as bone marrow syndrome when injected intraperitoneally (i.p.) before whole-body exposure to 11 Gy γ radiation. The optimum drug dose for protection was 50 μg/kg body weight: An increase in the drug dose did not increase protection. No acute toxicity was observed at doses as high as 100 mg/kg body weight of either compound. Maximum protection was obtained when either compound was injected i.p. 30 min before irradiation. Changing the route of administration or the interval between drug injection (i.p.) and irradiation reduced protection. Drug treatment after irradiation was not very effective. Vicenin was slightly better than orientin in increasing survival at 30 days; protection by vicenin also lasted longer. Dose modification factors (DMFs) for the LD50 were 1.37 for vicenin and 1.30 for orientin. Radical scavenging activity has been demonstrated for both orientin and vicenin, and this appears to be one of the mechanisms of protection by these flavonoids.

Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalRadiation Research
Volume151
Issue number1
DOIs
Publication statusPublished - 01-1999

Fingerprint

Ocimum
Flavonoids
drugs
Pharmaceutical Preparations
body weight
dosage
Body Weight
Radiation Dosage
irradiation
Plant Leaves
Lethal Dose 50
bone marrow
scavenging
Bone Marrow
vicenin
death
toxicity
leaves
mice
Injections

All Science Journal Classification (ASJC) codes

  • Radiation
  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Uma Devi, P., Ganasoundari, A., Rao, B. S. S., & Srinivasan, K. K. (1999). In vivo radioprotection by ocimum flavonoids: Survival. Radiation Research, 151(1), 74-78. https://doi.org/10.2307/3579750
Uma Devi, P. ; Ganasoundari, A. ; Rao, B. S.S. ; Srinivasan, K. K. / In vivo radioprotection by ocimum flavonoids : Survival. In: Radiation Research. 1999 ; Vol. 151, No. 1. pp. 74-78.
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Uma Devi, P, Ganasoundari, A, Rao, BSS & Srinivasan, KK 1999, 'In vivo radioprotection by ocimum flavonoids: Survival', Radiation Research, vol. 151, no. 1, pp. 74-78. https://doi.org/10.2307/3579750

In vivo radioprotection by ocimum flavonoids : Survival. / Uma Devi, P.; Ganasoundari, A.; Rao, B. S.S.; Srinivasan, K. K.

In: Radiation Research, Vol. 151, No. 1, 01.1999, p. 74-78.

Research output: Contribution to journalArticle

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