Increased expression of P-cadherin is an indicator of poor prognosis in breast cancer: a systematic review and meta-analysis

Sriya Sridhar, Christabelle Rajesh, Padacherri Vethil Jishnu, Pradyumna Jayaram, Shama Prasada Kabekkodu

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Purpose: P-cadherin (CDH3), located at 16q22.1 belonging to classical cadherin family, is a calcium-dependent glycoprotein associated with cell to cell adhesion, migration, and invasion in cancer. This meta-analysis was conducted to examine the prognostic utility of P-cadherin expression in breast cancer (BC). Methods: A comprehensive literature search was carried out using the available databases to obtain relevant research articles to test the relationship between P-cadherin and BC. Correlation of P-cadherin expression and disease-free survival (DFS) or overall survival (OS) was tested using hazard ratio (HR), relative risk (RR) at 95% confidence interval (CI) by univariate and/or multivariate analysis. A total of 11 studies from 7 countries were found to be relevant and were further subjected to statistical analysis to find an association between the P-cadherin expression with BC. Additionally, we have also performed a co-relation analysis of P-cadherin expression with GOBO and Cancertool in breast cancer using publicly available breast cancer datasets. Results: Our study shows that P-cadherin expression is significantly linked with poor prognosis in the various subtypes of BC. The HR for OS and DFS was 1.87 (95% CI = 1.48–2.36) and 1.64 (95% CI = 1.18–2.27) respectively. Conclusions: In this meta-analysis, we identified a positive correlation between the overexpression of P-cadherin and BC. Our study demonstrates that P-cadherin overexpression can be used as a prognostic indicator in BC.

Original languageEnglish
JournalBreast Cancer Research and Treatment
DOIs
Publication statusAccepted/In press - 01-01-2019

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Cadherins
Meta-Analysis
Breast Neoplasms
Confidence Intervals
Disease-Free Survival
Cell Adhesion
Cell Movement
Glycoproteins
Multivariate Analysis
Databases
Calcium

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

@article{34abe1b9c3f843549b0d7cd3a3a0833a,
title = "Increased expression of P-cadherin is an indicator of poor prognosis in breast cancer: a systematic review and meta-analysis",
abstract = "Purpose: P-cadherin (CDH3), located at 16q22.1 belonging to classical cadherin family, is a calcium-dependent glycoprotein associated with cell to cell adhesion, migration, and invasion in cancer. This meta-analysis was conducted to examine the prognostic utility of P-cadherin expression in breast cancer (BC). Methods: A comprehensive literature search was carried out using the available databases to obtain relevant research articles to test the relationship between P-cadherin and BC. Correlation of P-cadherin expression and disease-free survival (DFS) or overall survival (OS) was tested using hazard ratio (HR), relative risk (RR) at 95{\%} confidence interval (CI) by univariate and/or multivariate analysis. A total of 11 studies from 7 countries were found to be relevant and were further subjected to statistical analysis to find an association between the P-cadherin expression with BC. Additionally, we have also performed a co-relation analysis of P-cadherin expression with GOBO and Cancertool in breast cancer using publicly available breast cancer datasets. Results: Our study shows that P-cadherin expression is significantly linked with poor prognosis in the various subtypes of BC. The HR for OS and DFS was 1.87 (95{\%} CI = 1.48–2.36) and 1.64 (95{\%} CI = 1.18–2.27) respectively. Conclusions: In this meta-analysis, we identified a positive correlation between the overexpression of P-cadherin and BC. Our study demonstrates that P-cadherin overexpression can be used as a prognostic indicator in BC.",
author = "Sriya Sridhar and Christabelle Rajesh and Jishnu, {Padacherri Vethil} and Pradyumna Jayaram and Kabekkodu, {Shama Prasada}",
year = "2019",
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day = "1",
doi = "10.1007/s10549-019-05477-5",
language = "English",
journal = "Breast Cancer Research and Treatment",
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Increased expression of P-cadherin is an indicator of poor prognosis in breast cancer : a systematic review and meta-analysis. / Sridhar, Sriya; Rajesh, Christabelle; Jishnu, Padacherri Vethil; Jayaram, Pradyumna; Kabekkodu, Shama Prasada.

In: Breast Cancer Research and Treatment, 01.01.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Increased expression of P-cadherin is an indicator of poor prognosis in breast cancer

T2 - a systematic review and meta-analysis

AU - Sridhar, Sriya

AU - Rajesh, Christabelle

AU - Jishnu, Padacherri Vethil

AU - Jayaram, Pradyumna

AU - Kabekkodu, Shama Prasada

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: P-cadherin (CDH3), located at 16q22.1 belonging to classical cadherin family, is a calcium-dependent glycoprotein associated with cell to cell adhesion, migration, and invasion in cancer. This meta-analysis was conducted to examine the prognostic utility of P-cadherin expression in breast cancer (BC). Methods: A comprehensive literature search was carried out using the available databases to obtain relevant research articles to test the relationship between P-cadherin and BC. Correlation of P-cadherin expression and disease-free survival (DFS) or overall survival (OS) was tested using hazard ratio (HR), relative risk (RR) at 95% confidence interval (CI) by univariate and/or multivariate analysis. A total of 11 studies from 7 countries were found to be relevant and were further subjected to statistical analysis to find an association between the P-cadherin expression with BC. Additionally, we have also performed a co-relation analysis of P-cadherin expression with GOBO and Cancertool in breast cancer using publicly available breast cancer datasets. Results: Our study shows that P-cadherin expression is significantly linked with poor prognosis in the various subtypes of BC. The HR for OS and DFS was 1.87 (95% CI = 1.48–2.36) and 1.64 (95% CI = 1.18–2.27) respectively. Conclusions: In this meta-analysis, we identified a positive correlation between the overexpression of P-cadherin and BC. Our study demonstrates that P-cadherin overexpression can be used as a prognostic indicator in BC.

AB - Purpose: P-cadherin (CDH3), located at 16q22.1 belonging to classical cadherin family, is a calcium-dependent glycoprotein associated with cell to cell adhesion, migration, and invasion in cancer. This meta-analysis was conducted to examine the prognostic utility of P-cadherin expression in breast cancer (BC). Methods: A comprehensive literature search was carried out using the available databases to obtain relevant research articles to test the relationship between P-cadherin and BC. Correlation of P-cadherin expression and disease-free survival (DFS) or overall survival (OS) was tested using hazard ratio (HR), relative risk (RR) at 95% confidence interval (CI) by univariate and/or multivariate analysis. A total of 11 studies from 7 countries were found to be relevant and were further subjected to statistical analysis to find an association between the P-cadherin expression with BC. Additionally, we have also performed a co-relation analysis of P-cadherin expression with GOBO and Cancertool in breast cancer using publicly available breast cancer datasets. Results: Our study shows that P-cadherin expression is significantly linked with poor prognosis in the various subtypes of BC. The HR for OS and DFS was 1.87 (95% CI = 1.48–2.36) and 1.64 (95% CI = 1.18–2.27) respectively. Conclusions: In this meta-analysis, we identified a positive correlation between the overexpression of P-cadherin and BC. Our study demonstrates that P-cadherin overexpression can be used as a prognostic indicator in BC.

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M3 - Review article

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JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

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