Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy

Jyothi M.P. D’souza, Sindhu Harish, Vinitha Ramanath Pai, Chitra Shriyan

Research output: Contribution to journalArticle

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Abstract

Protein oxidation has been demonstrated in preeclampsia, but this finding has not been established in other hypertensive disorders in pregnancy (HDP). The present study comparatively evaluated ischemia modified albumin (IMA) and advanced oxidation protein products (AOPP) in different HDP and investigated their association with total antioxidant activity (AOA) and total thiols. There was a significant increase in AOPP and IMA, a significant decrease in AOA, total thiols and albumin in every HDP compared to controls. Among HDP groups, eclampsia patients showed more significant change in each of the parameter. IMA and AOPP were negatively associated with AOA in every HDP and with total thiols only in eclampsia. The present study supports the hypothesis of oxidative stress, as evidenced by increased protein oxidation, decreased antioxidant status and significant negative association between protein oxidation and AOA in every HDP. The imbalance of prooxidants and antioxidants was further augmented in eclampsia.

Original languageEnglish
Pages (from-to)200-206
Number of pages7
JournalIndian Journal of Clinical Biochemistry
Volume32
Issue number2
DOIs
Publication statusPublished - 01-06-2017

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Albumins
Advanced Oxidation Protein Products
Antioxidants
Pregnancy
Eclampsia
Sulfhydryl Compounds
Oxidation
Association reactions
Proteins
Oxidative stress
Pre-Eclampsia
Oxidative Stress
ischemia-modified albumin

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

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abstract = "Protein oxidation has been demonstrated in preeclampsia, but this finding has not been established in other hypertensive disorders in pregnancy (HDP). The present study comparatively evaluated ischemia modified albumin (IMA) and advanced oxidation protein products (AOPP) in different HDP and investigated their association with total antioxidant activity (AOA) and total thiols. There was a significant increase in AOPP and IMA, a significant decrease in AOA, total thiols and albumin in every HDP compared to controls. Among HDP groups, eclampsia patients showed more significant change in each of the parameter. IMA and AOPP were negatively associated with AOA in every HDP and with total thiols only in eclampsia. The present study supports the hypothesis of oxidative stress, as evidenced by increased protein oxidation, decreased antioxidant status and significant negative association between protein oxidation and AOA in every HDP. The imbalance of prooxidants and antioxidants was further augmented in eclampsia.",
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Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy. / D’souza, Jyothi M.P.; Harish, Sindhu; Pai, Vinitha Ramanath; Shriyan, Chitra.

In: Indian Journal of Clinical Biochemistry, Vol. 32, No. 2, 01.06.2017, p. 200-206.

Research output: Contribution to journalArticle

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