Indicators of oxidative stress in thyroid cancer

Bhargav Kodurua, Tejaswinia, Ajit Thakura, Shobha U. Kamatha, Kallya Rajgopal Shenoy, Ullas Kamathc, K. Reshmad

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Ferric reducing antioxidant power (FRAP), myeloperoxidase (MPO) activity and the levels of protein thiols and carbonyls were estimated in the blood samples of thyroid cancer patients (n = 20) before and after thyroidectomy, as well as in healthy controls (n = 10) to study the extent of damage caused by tumor tissue proliferation-induced oxidative stress and to ascertain that oxidative stress levels drop, when there was no proliferation. A significant decrease (p<0.001) in the levels of serum protein thiols and FRAP as well as a significant increase (p<0.001) in the levels of protein carbonyls and MPO activity in the blood of thyroid cancer patients before surgery was observed as compared to healthy controls. All the parameters studied also showed a significant difference (p<0.001) in their respective levels in thyroid cancer patients, preand post-thyroidectomy. These findings present the role of oxidative stress as a pathological implication of thyroid cancer.

Original languageEnglish
Pages (from-to)121-123
Number of pages3
JournalIndian Journal of Biochemistry and Biophysics
Volume47
Issue number2
Publication statusPublished - 04-2010

Fingerprint

Oxidative stress
Thyroid Neoplasms
Oxidative Stress
Sulfhydryl Compounds
Peroxidase
Thyroidectomy
Blood
Antioxidants
Surgery
Blood Proteins
Tumors
Proteins
Tissue
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry

Cite this

Kodurua, Bhargav ; Tejaswinia ; Thakura, Ajit ; Kamatha, Shobha U. ; Shenoy, Kallya Rajgopal ; Kamathc, Ullas ; Reshmad, K. / Indicators of oxidative stress in thyroid cancer. In: Indian Journal of Biochemistry and Biophysics. 2010 ; Vol. 47, No. 2. pp. 121-123.
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Indicators of oxidative stress in thyroid cancer. / Kodurua, Bhargav; Tejaswinia; Thakura, Ajit; Kamatha, Shobha U.; Shenoy, Kallya Rajgopal; Kamathc, Ullas; Reshmad, K.

In: Indian Journal of Biochemistry and Biophysics, Vol. 47, No. 2, 04.2010, p. 121-123.

Research output: Contribution to journalArticle

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AU - Tejaswinia,

AU - Thakura, Ajit

AU - Kamatha, Shobha U.

AU - Shenoy, Kallya Rajgopal

AU - Kamathc, Ullas

AU - Reshmad, K.

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Kodurua B, Tejaswinia, Thakura A, Kamatha SU, Shenoy KR, Kamathc U et al. Indicators of oxidative stress in thyroid cancer. Indian Journal of Biochemistry and Biophysics. 2010 Apr;47(2):121-123.