Abstract

Ferric reducing antioxidant power (FRAP), myeloperoxidase (MPO) activity and the levels of protein thiols and carbonyls were estimated in the blood samples of thyroid cancer patients (n = 20) before and after thyroidectomy, as well as in healthy controls (n = 10) to study the extent of damage caused by tumor tissue proliferation-induced oxidative stress and to ascertain that oxidative stress levels drop, when there was no proliferation. A significant decrease (p<0.001) in the levels of serum protein thiols and FRAP as well as a significant increase (p<0.001) in the levels of protein carbonyls and MPO activity in the blood of thyroid cancer patients before surgery was observed as compared to healthy controls. All the parameters studied also showed a significant difference (p<0.001) in their respective levels in thyroid cancer patients, preand post-thyroidectomy. These findings present the role of oxidative stress as a pathological implication of thyroid cancer.

Original languageEnglish
Pages (from-to)121-123
Number of pages3
JournalIndian Journal of Geo-Marine Sciences
Volume47
Issue number2
Publication statusPublished - 2010

Fingerprint

cancer
thiol
antioxidant
protein
blood
tumor
serum
damage
indicator
oxidative stress

All Science Journal Classification (ASJC) codes

  • Oceanography

Cite this

@article{b84c6abeac2b43ab980cc709b22c14be,
title = "Indicators of oxidative stress in thyroid cancer",
abstract = "Ferric reducing antioxidant power (FRAP), myeloperoxidase (MPO) activity and the levels of protein thiols and carbonyls were estimated in the blood samples of thyroid cancer patients (n = 20) before and after thyroidectomy, as well as in healthy controls (n = 10) to study the extent of damage caused by tumor tissue proliferation-induced oxidative stress and to ascertain that oxidative stress levels drop, when there was no proliferation. A significant decrease (p<0.001) in the levels of serum protein thiols and FRAP as well as a significant increase (p<0.001) in the levels of protein carbonyls and MPO activity in the blood of thyroid cancer patients before surgery was observed as compared to healthy controls. All the parameters studied also showed a significant difference (p<0.001) in their respective levels in thyroid cancer patients, preand post-thyroidectomy. These findings present the role of oxidative stress as a pathological implication of thyroid cancer.",
author = "Bhargav Koduru and Tejaswini and Ajit Thakur and Kamath, {Shobha U.} and Shenoy, {Kallya Rajgopal} and Ullas Kamath and K. Reshma",
year = "2010",
language = "English",
volume = "47",
pages = "121--123",
journal = "Indian Journal of Geo-Marine Sciences",
issn = "0379-5136",
publisher = "National Institute of Science Communication and Information Resources (NISCAIR)",
number = "2",

}

Indicators of oxidative stress in thyroid cancer. / Koduru, Bhargav; Tejaswini; Thakur, Ajit; Kamath, Shobha U.; Shenoy, Kallya Rajgopal; Kamath, Ullas; Reshma, K.

In: Indian Journal of Geo-Marine Sciences, Vol. 47, No. 2, 2010, p. 121-123.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Indicators of oxidative stress in thyroid cancer

AU - Koduru, Bhargav

AU - Tejaswini,

AU - Thakur, Ajit

AU - Kamath, Shobha U.

AU - Shenoy, Kallya Rajgopal

AU - Kamath, Ullas

AU - Reshma, K.

PY - 2010

Y1 - 2010

N2 - Ferric reducing antioxidant power (FRAP), myeloperoxidase (MPO) activity and the levels of protein thiols and carbonyls were estimated in the blood samples of thyroid cancer patients (n = 20) before and after thyroidectomy, as well as in healthy controls (n = 10) to study the extent of damage caused by tumor tissue proliferation-induced oxidative stress and to ascertain that oxidative stress levels drop, when there was no proliferation. A significant decrease (p<0.001) in the levels of serum protein thiols and FRAP as well as a significant increase (p<0.001) in the levels of protein carbonyls and MPO activity in the blood of thyroid cancer patients before surgery was observed as compared to healthy controls. All the parameters studied also showed a significant difference (p<0.001) in their respective levels in thyroid cancer patients, preand post-thyroidectomy. These findings present the role of oxidative stress as a pathological implication of thyroid cancer.

AB - Ferric reducing antioxidant power (FRAP), myeloperoxidase (MPO) activity and the levels of protein thiols and carbonyls were estimated in the blood samples of thyroid cancer patients (n = 20) before and after thyroidectomy, as well as in healthy controls (n = 10) to study the extent of damage caused by tumor tissue proliferation-induced oxidative stress and to ascertain that oxidative stress levels drop, when there was no proliferation. A significant decrease (p<0.001) in the levels of serum protein thiols and FRAP as well as a significant increase (p<0.001) in the levels of protein carbonyls and MPO activity in the blood of thyroid cancer patients before surgery was observed as compared to healthy controls. All the parameters studied also showed a significant difference (p<0.001) in their respective levels in thyroid cancer patients, preand post-thyroidectomy. These findings present the role of oxidative stress as a pathological implication of thyroid cancer.

UR - http://www.scopus.com/inward/record.url?scp=84924240391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924240391&partnerID=8YFLogxK

M3 - Article

VL - 47

SP - 121

EP - 123

JO - Indian Journal of Geo-Marine Sciences

JF - Indian Journal of Geo-Marine Sciences

SN - 0379-5136

IS - 2

ER -