Indices of oxidative stress in smokers

Research output: Contribution to journalArticle

Abstract

Background and Objectives: A strong association has been found between smoking and various diseases like cerebrovascular disease, various types of cancer and heart disease. Oxidative stress has been implicated as the cause for all these diseases. The present study aims to evaluate oxidative stress and α1-antitrypsin levels in healthy chronic smokers by estimation of protein oxidation products, namely, advanced oxidation protein products (AOPPs) and protein carbonyls (PCs), and the antioxidants: reduced glutathione (GSH) and albumin and total thiols. Materials and Methods: All the parameters were determined spectrophotometrically. The parameters were determined in 25 male smokers and compared with 25 controls. Results: Statistically significant increases were seen in the levels of AOPP and PC while albumin showed statistically significant decrease. α1 - Antitrypsin levels did not show any statistical difference between the two groups. Conclusion: These findings indicate an increased level of oxidative stress as shown by the increase in protein oxidation products and a decrease in the albumin level. It also suggests increased damage to proteins which could lead to various pathologies observed in smokers. Employing AOPP and PC as measures of oxidative stress, use of various antioxidant vitamins to decrease oxidative stress levels in smokers can be considered.

Original languageEnglish
Pages (from-to)543-546
Number of pages4
JournalBiomedicine (India)
Volume32
Issue number4
Publication statusPublished - 01-10-2012

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Oxidative stress
Advanced Oxidation Protein Products
Oxidative Stress
Albumins
Proteins
Antioxidants
Oxidation
Cerebrovascular Disorders
Pathology
Sulfhydryl Compounds
Vitamins
Glutathione
Association reactions
Heart Diseases
Smoking
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Indices of oxidative stress in smokers",
abstract = "Background and Objectives: A strong association has been found between smoking and various diseases like cerebrovascular disease, various types of cancer and heart disease. Oxidative stress has been implicated as the cause for all these diseases. The present study aims to evaluate oxidative stress and α1-antitrypsin levels in healthy chronic smokers by estimation of protein oxidation products, namely, advanced oxidation protein products (AOPPs) and protein carbonyls (PCs), and the antioxidants: reduced glutathione (GSH) and albumin and total thiols. Materials and Methods: All the parameters were determined spectrophotometrically. The parameters were determined in 25 male smokers and compared with 25 controls. Results: Statistically significant increases were seen in the levels of AOPP and PC while albumin showed statistically significant decrease. α1 - Antitrypsin levels did not show any statistical difference between the two groups. Conclusion: These findings indicate an increased level of oxidative stress as shown by the increase in protein oxidation products and a decrease in the albumin level. It also suggests increased damage to proteins which could lead to various pathologies observed in smokers. Employing AOPP and PC as measures of oxidative stress, use of various antioxidant vitamins to decrease oxidative stress levels in smokers can be considered.",
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Indices of oxidative stress in smokers. / Bhandari, Sameer; Shetty, Beena V.; Sudha, K.; Rao, Gayathri M.

In: Biomedicine (India), Vol. 32, No. 4, 01.10.2012, p. 543-546.

Research output: Contribution to journalArticle

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AU - Bhandari, Sameer

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AU - Rao, Gayathri M.

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AB - Background and Objectives: A strong association has been found between smoking and various diseases like cerebrovascular disease, various types of cancer and heart disease. Oxidative stress has been implicated as the cause for all these diseases. The present study aims to evaluate oxidative stress and α1-antitrypsin levels in healthy chronic smokers by estimation of protein oxidation products, namely, advanced oxidation protein products (AOPPs) and protein carbonyls (PCs), and the antioxidants: reduced glutathione (GSH) and albumin and total thiols. Materials and Methods: All the parameters were determined spectrophotometrically. The parameters were determined in 25 male smokers and compared with 25 controls. Results: Statistically significant increases were seen in the levels of AOPP and PC while albumin showed statistically significant decrease. α1 - Antitrypsin levels did not show any statistical difference between the two groups. Conclusion: These findings indicate an increased level of oxidative stress as shown by the increase in protein oxidation products and a decrease in the albumin level. It also suggests increased damage to proteins which could lead to various pathologies observed in smokers. Employing AOPP and PC as measures of oxidative stress, use of various antioxidant vitamins to decrease oxidative stress levels in smokers can be considered.

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