Inducible clindamycin resistance among clinical isolates of staphylococci

A. Ciraj, P. Vinod, G. Sreejith, K. Rajani

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Introduction: Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to macrolide, lincosamide and streptogramin antibiotics. This study was undertaken to detect the presence of inducible clindamycin resistance among clinical isolates of staphylococci. Materials and Methods: The detection of inducible clindamycin resistance was performed by D-test using erythromycin and clindamycin discs as per CDC guidelines. Results: Among the 244 clinical isolates of staphylococci studied, 32 (13.1%) showed inducible clindamycin resistance and belonged to the MLS Bi phenotype. Among the MLSBi phenotypes, 10 isolates were methicillin-resistant Staphylococcus aureus (38.4% of the total MRSA), 16 were methicillin-sensitive Staphylococcus aureus (12.9% of the total MSSA) and 6 were coagulase-negative staphylococci (6.3% of the total CONS). Conclusion: The test for inducible resistance to clindamycin should be included in the routine antibiotic susceptibility testing, as it will help in guiding therapy.

Original languageEnglish
Pages (from-to)49-51
Number of pages3
JournalIndian Journal of Pathology and Microbiology
Volume52
Issue number1
DOIs
Publication statusPublished - 01-01-2009

Fingerprint

Clindamycin
Staphylococcus
Methicillin-Resistant Staphylococcus aureus
Streptogramins
Lincosamides
Anti-Bacterial Agents
Phenotype
Methicillin
Coagulase
Macrolides
Erythromycin
Centers for Disease Control and Prevention (U.S.)
Staphylococcus aureus
Guidelines
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Microbiology (medical)

Cite this

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Inducible clindamycin resistance among clinical isolates of staphylococci. / Ciraj, A.; Vinod, P.; Sreejith, G.; Rajani, K.

In: Indian Journal of Pathology and Microbiology, Vol. 52, No. 1, 01.01.2009, p. 49-51.

Research output: Contribution to journalArticle

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AB - Introduction: Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to macrolide, lincosamide and streptogramin antibiotics. This study was undertaken to detect the presence of inducible clindamycin resistance among clinical isolates of staphylococci. Materials and Methods: The detection of inducible clindamycin resistance was performed by D-test using erythromycin and clindamycin discs as per CDC guidelines. Results: Among the 244 clinical isolates of staphylococci studied, 32 (13.1%) showed inducible clindamycin resistance and belonged to the MLS Bi phenotype. Among the MLSBi phenotypes, 10 isolates were methicillin-resistant Staphylococcus aureus (38.4% of the total MRSA), 16 were methicillin-sensitive Staphylococcus aureus (12.9% of the total MSSA) and 6 were coagulase-negative staphylococci (6.3% of the total CONS). Conclusion: The test for inducible resistance to clindamycin should be included in the routine antibiotic susceptibility testing, as it will help in guiding therapy.

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