Inducible protective processes in animal systems. IX. Potentiality of adaptive response by nicotinamide in MMS adapted meiotic cells of grasshopper Poecilocerus pictus

Kanive P. Guruprasad, Venkateshaiah Vasudev

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The discovery of adaptive response E. coli induced by low doses of alkylating agent has lead to an extensive research in understanding the existence of such process. There are reports on adaptive response in in vivo and in vitro systems. Recently we also have shown such phenomena in in vivo grasshopper Poecilocerus pictus and mouse test systems. Different repair enzymes are implicated in this process viz. O6-methyI guanine methyl transferase, poly (ADP-ribose) polymerase etc. In the present study an attempt has been made to understand the involvement of PARP in methyl methane sulfonate (MMS)-induced adaptive response in meiotic cells of grasshopper P. pictus by employing nicotinamide, an inhibitor of PARP. Three sets of experiments viz. pre-, inter-, and post- treatment of Nicotinamide were carried out. The results of these experiments have revealed that there is a reduction in the frequency of chromosomal anomalies compared to combined treatment at all recovery times tested indicating the enhancement of adaptive response by nicotinamide. These results are discussed in the light of involvement of PAR.P in adaptive response.

Original languageEnglish
Pages (from-to)649-654
Number of pages6
JournalBiologia
Volume56
Issue number6
Publication statusPublished - 2001

Fingerprint

methyl methanesulfonate
nicotinamide
Grasshoppers
Niacinamide
grasshopper
Methane
sulfonate
grasshoppers
Animals
methane
animal
photosynthetically active radiation
repair
inhibitor
NAD ADP-ribosyltransferase
animals
Poly(ADP-ribose) Polymerases
experiment
Alkylating Agents
guanine

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Molecular Biology
  • Animal Science and Zoology
  • Genetics
  • Plant Science
  • Cell Biology

Cite this

@article{1e50de661dc647709be0315b86f6b7d5,
title = "Inducible protective processes in animal systems. IX. Potentiality of adaptive response by nicotinamide in MMS adapted meiotic cells of grasshopper Poecilocerus pictus",
abstract = "The discovery of adaptive response E. coli induced by low doses of alkylating agent has lead to an extensive research in understanding the existence of such process. There are reports on adaptive response in in vivo and in vitro systems. Recently we also have shown such phenomena in in vivo grasshopper Poecilocerus pictus and mouse test systems. Different repair enzymes are implicated in this process viz. O6-methyI guanine methyl transferase, poly (ADP-ribose) polymerase etc. In the present study an attempt has been made to understand the involvement of PARP in methyl methane sulfonate (MMS)-induced adaptive response in meiotic cells of grasshopper P. pictus by employing nicotinamide, an inhibitor of PARP. Three sets of experiments viz. pre-, inter-, and post- treatment of Nicotinamide were carried out. The results of these experiments have revealed that there is a reduction in the frequency of chromosomal anomalies compared to combined treatment at all recovery times tested indicating the enhancement of adaptive response by nicotinamide. These results are discussed in the light of involvement of PAR.P in adaptive response.",
author = "Guruprasad, {Kanive P.} and Venkateshaiah Vasudev",
year = "2001",
language = "English",
volume = "56",
pages = "649--654",
journal = "Biologia (Poland)",
issn = "0006-3088",
publisher = "de Gruyter",
number = "6",

}

TY - JOUR

T1 - Inducible protective processes in animal systems. IX. Potentiality of adaptive response by nicotinamide in MMS adapted meiotic cells of grasshopper Poecilocerus pictus

AU - Guruprasad, Kanive P.

AU - Vasudev, Venkateshaiah

PY - 2001

Y1 - 2001

N2 - The discovery of adaptive response E. coli induced by low doses of alkylating agent has lead to an extensive research in understanding the existence of such process. There are reports on adaptive response in in vivo and in vitro systems. Recently we also have shown such phenomena in in vivo grasshopper Poecilocerus pictus and mouse test systems. Different repair enzymes are implicated in this process viz. O6-methyI guanine methyl transferase, poly (ADP-ribose) polymerase etc. In the present study an attempt has been made to understand the involvement of PARP in methyl methane sulfonate (MMS)-induced adaptive response in meiotic cells of grasshopper P. pictus by employing nicotinamide, an inhibitor of PARP. Three sets of experiments viz. pre-, inter-, and post- treatment of Nicotinamide were carried out. The results of these experiments have revealed that there is a reduction in the frequency of chromosomal anomalies compared to combined treatment at all recovery times tested indicating the enhancement of adaptive response by nicotinamide. These results are discussed in the light of involvement of PAR.P in adaptive response.

AB - The discovery of adaptive response E. coli induced by low doses of alkylating agent has lead to an extensive research in understanding the existence of such process. There are reports on adaptive response in in vivo and in vitro systems. Recently we also have shown such phenomena in in vivo grasshopper Poecilocerus pictus and mouse test systems. Different repair enzymes are implicated in this process viz. O6-methyI guanine methyl transferase, poly (ADP-ribose) polymerase etc. In the present study an attempt has been made to understand the involvement of PARP in methyl methane sulfonate (MMS)-induced adaptive response in meiotic cells of grasshopper P. pictus by employing nicotinamide, an inhibitor of PARP. Three sets of experiments viz. pre-, inter-, and post- treatment of Nicotinamide were carried out. The results of these experiments have revealed that there is a reduction in the frequency of chromosomal anomalies compared to combined treatment at all recovery times tested indicating the enhancement of adaptive response by nicotinamide. These results are discussed in the light of involvement of PAR.P in adaptive response.

UR - http://www.scopus.com/inward/record.url?scp=18044403932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18044403932&partnerID=8YFLogxK

M3 - Article

VL - 56

SP - 649

EP - 654

JO - Biologia (Poland)

JF - Biologia (Poland)

SN - 0006-3088

IS - 6

ER -