Inducible protective processes in animal systems. IX. Potentiality of adaptive response by nicotinamide in MMS adapted meiotic cells of grasshopper Poecilocerus pictus

Kanive P. Guruprasad, Venkateshaiah Vasudev

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    Abstract

    The discovery of adaptive response E. coli induced by low doses of alkylating agent has lead to an extensive research in understanding the existence of such process. There are reports on adaptive response in in vivo and in vitro systems. Recently we also have shown such phenomena in in vivo grasshopper Poecilocerus pictus and mouse test systems. Different repair enzymes are implicated in this process viz. O6-methyI guanine methyl transferase, poly (ADP-ribose) polymerase etc. In the present study an attempt has been made to understand the involvement of PARP in methyl methane sulfonate (MMS)-induced adaptive response in meiotic cells of grasshopper P. pictus by employing nicotinamide, an inhibitor of PARP. Three sets of experiments viz. pre-, inter-, and post- treatment of Nicotinamide were carried out. The results of these experiments have revealed that there is a reduction in the frequency of chromosomal anomalies compared to combined treatment at all recovery times tested indicating the enhancement of adaptive response by nicotinamide. These results are discussed in the light of involvement of PAR.P in adaptive response.

    Original languageEnglish
    Pages (from-to)649-654
    Number of pages6
    JournalBiologia
    Volume56
    Issue number6
    Publication statusPublished - 2001

    Fingerprint

    methyl methanesulfonate
    nicotinamide
    Grasshoppers
    Niacinamide
    grasshopper
    Methane
    sulfonate
    grasshoppers
    Animals
    methane
    animal
    photosynthetically active radiation
    repair
    inhibitor
    NAD ADP-ribosyltransferase
    animals
    Poly(ADP-ribose) Polymerases
    experiment
    Alkylating Agents
    guanine

    All Science Journal Classification (ASJC) codes

    • Ecology, Evolution, Behavior and Systematics
    • Biochemistry
    • Molecular Biology
    • Animal Science and Zoology
    • Genetics
    • Plant Science
    • Cell Biology

    Cite this

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    abstract = "The discovery of adaptive response E. coli induced by low doses of alkylating agent has lead to an extensive research in understanding the existence of such process. There are reports on adaptive response in in vivo and in vitro systems. Recently we also have shown such phenomena in in vivo grasshopper Poecilocerus pictus and mouse test systems. Different repair enzymes are implicated in this process viz. O6-methyI guanine methyl transferase, poly (ADP-ribose) polymerase etc. In the present study an attempt has been made to understand the involvement of PARP in methyl methane sulfonate (MMS)-induced adaptive response in meiotic cells of grasshopper P. pictus by employing nicotinamide, an inhibitor of PARP. Three sets of experiments viz. pre-, inter-, and post- treatment of Nicotinamide were carried out. The results of these experiments have revealed that there is a reduction in the frequency of chromosomal anomalies compared to combined treatment at all recovery times tested indicating the enhancement of adaptive response by nicotinamide. These results are discussed in the light of involvement of PAR.P in adaptive response.",
    author = "Guruprasad, {Kanive P.} and Venkateshaiah Vasudev",
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    AU - Guruprasad, Kanive P.

    AU - Vasudev, Venkateshaiah

    PY - 2001

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    N2 - The discovery of adaptive response E. coli induced by low doses of alkylating agent has lead to an extensive research in understanding the existence of such process. There are reports on adaptive response in in vivo and in vitro systems. Recently we also have shown such phenomena in in vivo grasshopper Poecilocerus pictus and mouse test systems. Different repair enzymes are implicated in this process viz. O6-methyI guanine methyl transferase, poly (ADP-ribose) polymerase etc. In the present study an attempt has been made to understand the involvement of PARP in methyl methane sulfonate (MMS)-induced adaptive response in meiotic cells of grasshopper P. pictus by employing nicotinamide, an inhibitor of PARP. Three sets of experiments viz. pre-, inter-, and post- treatment of Nicotinamide were carried out. The results of these experiments have revealed that there is a reduction in the frequency of chromosomal anomalies compared to combined treatment at all recovery times tested indicating the enhancement of adaptive response by nicotinamide. These results are discussed in the light of involvement of PAR.P in adaptive response.

    AB - The discovery of adaptive response E. coli induced by low doses of alkylating agent has lead to an extensive research in understanding the existence of such process. There are reports on adaptive response in in vivo and in vitro systems. Recently we also have shown such phenomena in in vivo grasshopper Poecilocerus pictus and mouse test systems. Different repair enzymes are implicated in this process viz. O6-methyI guanine methyl transferase, poly (ADP-ribose) polymerase etc. In the present study an attempt has been made to understand the involvement of PARP in methyl methane sulfonate (MMS)-induced adaptive response in meiotic cells of grasshopper P. pictus by employing nicotinamide, an inhibitor of PARP. Three sets of experiments viz. pre-, inter-, and post- treatment of Nicotinamide were carried out. The results of these experiments have revealed that there is a reduction in the frequency of chromosomal anomalies compared to combined treatment at all recovery times tested indicating the enhancement of adaptive response by nicotinamide. These results are discussed in the light of involvement of PAR.P in adaptive response.

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