Abstract
The molecular mechanism of the adaptive response or inducible DNA repair process has not been clearly demonstrated in eukaryotic systems. The involvement of poly(ADP-ribose) polymerase (PARP), a DNA repair enzyme has been reported in the adaptive response (Shadley and Wolff, 1987; Wiencke, 1987). Hence, the present studies were undertaken to understand the role of PARP in ethyl methanesulfonate (EMS)-induced adaptive response in mouse bone marrow cells by employing the inhibitor of this enzyme, nicotinamide. Inter-, pre- and post-treatments of nicotinamide with EMS were made. The results have revealed that there is a reduction in the frequencies of chromosomal aberrations compared with combined or challenge treatment at the different recovery times tested. These results are discussed with reference to the enhancement of the adaptive response by nicotinamide in mouse bone marrow cells.
| Original language | English |
|---|---|
| Pages (from-to) | 257-263 |
| Number of pages | 7 |
| Journal | Mutagenesis |
| Volume | 16 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2001 |
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All Science Journal Classification (ASJC) codes
- Toxicology
- Genetics
- Genetics(clinical)
- Health, Toxicology and Mutagenesis
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Inducible protective processes in animal systems : VIII. Enhancement of adaptive response by nicotinamide. / Guruprasad, K. P.; Vasudev, V.
In: Mutagenesis, Vol. 16, No. 3, 2001, p. 257-263.Research output: Contribution to journal › Article
TY - JOUR
T1 - Inducible protective processes in animal systems
T2 - VIII. Enhancement of adaptive response by nicotinamide
AU - Guruprasad, K. P.
AU - Vasudev, V.
PY - 2001
Y1 - 2001
N2 - The molecular mechanism of the adaptive response or inducible DNA repair process has not been clearly demonstrated in eukaryotic systems. The involvement of poly(ADP-ribose) polymerase (PARP), a DNA repair enzyme has been reported in the adaptive response (Shadley and Wolff, 1987; Wiencke, 1987). Hence, the present studies were undertaken to understand the role of PARP in ethyl methanesulfonate (EMS)-induced adaptive response in mouse bone marrow cells by employing the inhibitor of this enzyme, nicotinamide. Inter-, pre- and post-treatments of nicotinamide with EMS were made. The results have revealed that there is a reduction in the frequencies of chromosomal aberrations compared with combined or challenge treatment at the different recovery times tested. These results are discussed with reference to the enhancement of the adaptive response by nicotinamide in mouse bone marrow cells.
AB - The molecular mechanism of the adaptive response or inducible DNA repair process has not been clearly demonstrated in eukaryotic systems. The involvement of poly(ADP-ribose) polymerase (PARP), a DNA repair enzyme has been reported in the adaptive response (Shadley and Wolff, 1987; Wiencke, 1987). Hence, the present studies were undertaken to understand the role of PARP in ethyl methanesulfonate (EMS)-induced adaptive response in mouse bone marrow cells by employing the inhibitor of this enzyme, nicotinamide. Inter-, pre- and post-treatments of nicotinamide with EMS were made. The results have revealed that there is a reduction in the frequencies of chromosomal aberrations compared with combined or challenge treatment at the different recovery times tested. These results are discussed with reference to the enhancement of the adaptive response by nicotinamide in mouse bone marrow cells.
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U2 - 10.1093/mutage/16.3.257
DO - 10.1093/mutage/16.3.257
M3 - Article
VL - 16
SP - 257
EP - 263
JO - Mutagenesis
JF - Mutagenesis
SN - 0267-8357
IS - 3
ER -