Inducible protective processes in animal systems

VIII. Enhancement of adaptive response by nicotinamide

K. P. Guruprasad, V. Vasudev

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The molecular mechanism of the adaptive response or inducible DNA repair process has not been clearly demonstrated in eukaryotic systems. The involvement of poly(ADP-ribose) polymerase (PARP), a DNA repair enzyme has been reported in the adaptive response (Shadley and Wolff, 1987; Wiencke, 1987). Hence, the present studies were undertaken to understand the role of PARP in ethyl methanesulfonate (EMS)-induced adaptive response in mouse bone marrow cells by employing the inhibitor of this enzyme, nicotinamide. Inter-, pre- and post-treatments of nicotinamide with EMS were made. The results have revealed that there is a reduction in the frequencies of chromosomal aberrations compared with combined or challenge treatment at the different recovery times tested. These results are discussed with reference to the enhancement of the adaptive response by nicotinamide in mouse bone marrow cells.

Original languageEnglish
Pages (from-to)257-263
Number of pages7
JournalMutagenesis
Volume16
Issue number3
DOIs
Publication statusPublished - 2001

Fingerprint

Niacinamide
Ethyl Methanesulfonate
Animals
Poly(ADP-ribose) Polymerases
Bone Marrow Cells
Bone
Cells
DNA Repair Enzymes
Enzyme Inhibitors
Aberrations
Chromosome Aberrations
DNA Repair
Repair
Recovery
DNA

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Genetics
  • Genetics(clinical)
  • Health, Toxicology and Mutagenesis

Cite this

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Inducible protective processes in animal systems : VIII. Enhancement of adaptive response by nicotinamide. / Guruprasad, K. P.; Vasudev, V.

In: Mutagenesis, Vol. 16, No. 3, 2001, p. 257-263.

Research output: Contribution to journalArticle

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