Induction of chromosomal instability in mouse hemopoietic cells by fetal irradiation

P. U. Devi, M. Hossain

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Mice were exposed to 0.25-1.5Gy of gamma radiation on day 14 or 17 of gestation and chromosomal aberrations were scored in the bone marrow at 12 months of age. Irradiation had resulted in low peripheral blood counts, while some animals developed very high leukocyte counts. Exposed animals showed a significant dose dependent increase in the number of aberrant metaphases, compared to unexposed animals. Fragments and polyploidy were the major types of aberrations. Mice with abnormally high blood leukocyte counts showed a higher incidence of chromosomal aberrations, especially high levels of polyploidy than in animals with low blood counts. It is concluded that radiation induced genomic instability in the fetal hemopoietic cells of mouse is transmitted to postnatal and adult bone marrow which may lead to the development of hematological disorders, including malignancies. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume456
Issue number1-2
DOIs
Publication statusPublished - 30-11-2000
Externally publishedYes

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Chromosomal Instability
Polyploidy
Leukocyte Count
Chromosome Aberrations
Bone Marrow
Genomic Instability
Gamma Rays
Metaphase
Radiation
Pregnancy
Incidence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

Cite this

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Induction of chromosomal instability in mouse hemopoietic cells by fetal irradiation. / Devi, P. U.; Hossain, M.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 456, No. 1-2, 30.11.2000, p. 33-37.

Research output: Contribution to journalArticle

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