Induction of glutathione S-transferase activity by curcumin in mice

M. Susan, M.N.A. Rao

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Curcumin, a natural constituent of Curcuma longa (turmeric, CAS 458-37-7), has been studied for its induction of glutathione S-transferase activity in mice. At a dose of 250 mg/kg orally for 15 days, the enzyme activity in liver was increased by 1.8 fold. Its effect on other tissues like stomach, small intestine, lungs, kidney was not significant. Curcumin also depleted sulfhydryl levels in tissues, especially in stomach where 45% depletion was observed.
Original languageUndefined/Unknown
Pages (from-to)962-964
Number of pages3
JournalArzneimittel-Forschung/Drug Research
Volume42
Issue number7
Publication statusPublished - 1992
Externally publishedYes

Cite this

Susan, M. ; Rao, M.N.A. / Induction of glutathione S-transferase activity by curcumin in mice. In: Arzneimittel-Forschung/Drug Research. 1992 ; Vol. 42, No. 7. pp. 962-964.
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Induction of glutathione S-transferase activity by curcumin in mice. / Susan, M.; Rao, M.N.A.

In: Arzneimittel-Forschung/Drug Research, Vol. 42, No. 7, 1992, p. 962-964.

Research output: Contribution to journalArticle

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AU - Rao, M.N.A.

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AB - Curcumin, a natural constituent of Curcuma longa (turmeric, CAS 458-37-7), has been studied for its induction of glutathione S-transferase activity in mice. At a dose of 250 mg/kg orally for 15 days, the enzyme activity in liver was increased by 1.8 fold. Its effect on other tissues like stomach, small intestine, lungs, kidney was not significant. Curcumin also depleted sulfhydryl levels in tissues, especially in stomach where 45% depletion was observed.

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