Induction of resistance to fluoroquinolones in clinical and environmental isolates of Pseudomonas aeruginosa

Vishnu Prasad S., Mamatha Ballal, P. G. Shivananda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An attempt to induce resistance to ciprofloxacin invitro was made against clinical and environmental isolates of Pseudomonas aeruginosa. This invitro manipulation of strains resulted in the increase of minimum inhibitory concentration from 0.4 μg/ml to 1 μg/ml of the original strains to 9.0 to 12.5 μg/ml indicating development of resistance to ciprofloxacin and a major decrease in the size of zone diameters of norfloxacin and ofloxacin indicating cross resistance to these agents. Results indicate the induced resistance to ciprofloxacin can promote development of cross resistance to other fluoroquinolones. This suggests that caution should be taken while using fluoroquinolones for the treatment of Pseudomonas aeruginosa infections.

Original languageEnglish
Pages (from-to)94-96
Number of pages3
JournalIndian Journal of Pathology and Microbiology
Volume50
Issue number1
Publication statusPublished - 01-01-2007

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Fluoroquinolones
Ciprofloxacin
Pseudomonas aeruginosa
Pseudomonas Infections
Norfloxacin
Ofloxacin
Microbial Sensitivity Tests

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Microbiology (medical)

Cite this

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abstract = "An attempt to induce resistance to ciprofloxacin invitro was made against clinical and environmental isolates of Pseudomonas aeruginosa. This invitro manipulation of strains resulted in the increase of minimum inhibitory concentration from 0.4 μg/ml to 1 μg/ml of the original strains to 9.0 to 12.5 μg/ml indicating development of resistance to ciprofloxacin and a major decrease in the size of zone diameters of norfloxacin and ofloxacin indicating cross resistance to these agents. Results indicate the induced resistance to ciprofloxacin can promote development of cross resistance to other fluoroquinolones. This suggests that caution should be taken while using fluoroquinolones for the treatment of Pseudomonas aeruginosa infections.",
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