Industrially scalable synthesis of anti-alzheimer drug donepezil

Santosh L. Gaonkar, Y. F. Nadaf, Dinesh Bilehal, Nitinkumar S. Shetty

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Abstract

This paper describes a simple, efficient and industrially scalable total synthesis of donepezil hydrochloride. The article also reported the X-ray studies of the 2-(1-benzylpiperidin-4-ylmethyliden)-5,6-dimethoxyindan-1-one, an intermediate in the synthesis of donepezil. The crystal structure analysis of 2-(1-benzylpiperidin-4-ylmethyliden)-5,6-dimethoxyindan-1-one shows that it crystallizes in monoclinic class under the space group P121/c1 with cell parameters, a = 17.2992(7) Å, b = 10.1999(4) Å, c = 11.9539(5) Å, β = 103.450(2)°, V = 2051.42(15) Å3 and Z = 4.

Original languageEnglish
Pages (from-to)1999-2004
Number of pages6
JournalAsian Journal of Chemistry
Volume29
Issue number9
DOIs
Publication statusPublished - 2017

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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