Inflammatory Myofibroblastic Tumor: A Rapidly Growing Soft Tissue Mass in the Posterior Mandible

Parul Sah, Aditi Amit Byatnal, Lakshmi Rao, Venkadasalapathy Narayanaswamy, Raghu Radhakrishnan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The term inflammatory myofibroblastic tumor (IMT) encompasses a diverse group of spindle cell entities that traverses a clinical and histologic spectrum, extending from reactive to benign neoplastic to highly aggressive with malignant inclinations. Head and neck IMTs are rarely seen and comprise less than 5 % of tumors. Here we report a case of a 30 year old male who presented with a rapidly enlarging and extremely painful growth in the right posterior mandible, post extraction. Histopathological examination revealed a highly cellular connective tissue stroma comprised of spindle shaped cells arranged in fascicles, admixed with inflammatory cells, predominantly plasma cells. Apart from routine hematological investigations, serum protein electrophoresis was also performed. The final diagnosis was confirmed by a panel of immunomarkers consisting of MPO, CD34, CD20, CD3, CD23, CD138, SMA and ALK. To the best of our knowledge, this is the third case of oral IMT arising from an extraction socket.

Original languageEnglish
Pages (from-to)393-397
Number of pages5
JournalHead and Neck Pathology
Volume7
Issue number4
DOIs
Publication statusPublished - 12-2013

Fingerprint

Mandible
Neoplasms
Plasma Cells
Connective Tissue
Electrophoresis
Blood Proteins
Neck
Head
Growth

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oncology
  • Otorhinolaryngology

Cite this

Sah, Parul ; Byatnal, Aditi Amit ; Rao, Lakshmi ; Narayanaswamy, Venkadasalapathy ; Radhakrishnan, Raghu. / Inflammatory Myofibroblastic Tumor : A Rapidly Growing Soft Tissue Mass in the Posterior Mandible. In: Head and Neck Pathology. 2013 ; Vol. 7, No. 4. pp. 393-397.
@article{33dde17f0fcc4a60bec97ad5ce51c42b,
title = "Inflammatory Myofibroblastic Tumor: A Rapidly Growing Soft Tissue Mass in the Posterior Mandible",
abstract = "The term inflammatory myofibroblastic tumor (IMT) encompasses a diverse group of spindle cell entities that traverses a clinical and histologic spectrum, extending from reactive to benign neoplastic to highly aggressive with malignant inclinations. Head and neck IMTs are rarely seen and comprise less than 5 {\%} of tumors. Here we report a case of a 30 year old male who presented with a rapidly enlarging and extremely painful growth in the right posterior mandible, post extraction. Histopathological examination revealed a highly cellular connective tissue stroma comprised of spindle shaped cells arranged in fascicles, admixed with inflammatory cells, predominantly plasma cells. Apart from routine hematological investigations, serum protein electrophoresis was also performed. The final diagnosis was confirmed by a panel of immunomarkers consisting of MPO, CD34, CD20, CD3, CD23, CD138, SMA and ALK. To the best of our knowledge, this is the third case of oral IMT arising from an extraction socket.",
author = "Parul Sah and Byatnal, {Aditi Amit} and Lakshmi Rao and Venkadasalapathy Narayanaswamy and Raghu Radhakrishnan",
year = "2013",
month = "12",
doi = "10.1007/s12105-013-0474-8",
language = "English",
volume = "7",
pages = "393--397",
journal = "Head and Neck Pathology",
issn = "1936-055X",
publisher = "Humana Press",
number = "4",

}

Inflammatory Myofibroblastic Tumor : A Rapidly Growing Soft Tissue Mass in the Posterior Mandible. / Sah, Parul; Byatnal, Aditi Amit; Rao, Lakshmi; Narayanaswamy, Venkadasalapathy; Radhakrishnan, Raghu.

In: Head and Neck Pathology, Vol. 7, No. 4, 12.2013, p. 393-397.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Inflammatory Myofibroblastic Tumor

T2 - A Rapidly Growing Soft Tissue Mass in the Posterior Mandible

AU - Sah, Parul

AU - Byatnal, Aditi Amit

AU - Rao, Lakshmi

AU - Narayanaswamy, Venkadasalapathy

AU - Radhakrishnan, Raghu

PY - 2013/12

Y1 - 2013/12

N2 - The term inflammatory myofibroblastic tumor (IMT) encompasses a diverse group of spindle cell entities that traverses a clinical and histologic spectrum, extending from reactive to benign neoplastic to highly aggressive with malignant inclinations. Head and neck IMTs are rarely seen and comprise less than 5 % of tumors. Here we report a case of a 30 year old male who presented with a rapidly enlarging and extremely painful growth in the right posterior mandible, post extraction. Histopathological examination revealed a highly cellular connective tissue stroma comprised of spindle shaped cells arranged in fascicles, admixed with inflammatory cells, predominantly plasma cells. Apart from routine hematological investigations, serum protein electrophoresis was also performed. The final diagnosis was confirmed by a panel of immunomarkers consisting of MPO, CD34, CD20, CD3, CD23, CD138, SMA and ALK. To the best of our knowledge, this is the third case of oral IMT arising from an extraction socket.

AB - The term inflammatory myofibroblastic tumor (IMT) encompasses a diverse group of spindle cell entities that traverses a clinical and histologic spectrum, extending from reactive to benign neoplastic to highly aggressive with malignant inclinations. Head and neck IMTs are rarely seen and comprise less than 5 % of tumors. Here we report a case of a 30 year old male who presented with a rapidly enlarging and extremely painful growth in the right posterior mandible, post extraction. Histopathological examination revealed a highly cellular connective tissue stroma comprised of spindle shaped cells arranged in fascicles, admixed with inflammatory cells, predominantly plasma cells. Apart from routine hematological investigations, serum protein electrophoresis was also performed. The final diagnosis was confirmed by a panel of immunomarkers consisting of MPO, CD34, CD20, CD3, CD23, CD138, SMA and ALK. To the best of our knowledge, this is the third case of oral IMT arising from an extraction socket.

UR - http://www.scopus.com/inward/record.url?scp=84886748435&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886748435&partnerID=8YFLogxK

U2 - 10.1007/s12105-013-0474-8

DO - 10.1007/s12105-013-0474-8

M3 - Article

C2 - 23843049

AN - SCOPUS:84886748435

VL - 7

SP - 393

EP - 397

JO - Head and Neck Pathology

JF - Head and Neck Pathology

SN - 1936-055X

IS - 4

ER -