Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells

Kanive P. Guruprasad, Sweta Dash, Marigowda B. Shivakumar, Pavithra R. Shetty, Kothanahalli S. Raghu, Bhanuvalli R. Shamprasad, Vishwanatha Udupi, Raviraj V. Acharya, Prasanna B. Vidya, Jayakrishna Nayak, Anandan E. Mana, Rajesh Moni, Muraleedharan T. Sankaran, Kapaettu Satyamoorthy

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Abstract

Background Indian traditional medicine practices use defined rasayana preparations to improve the quality of life in aged individuals. Amalaki Rasayana is one such rasayana prepared from the fruits of Phyllanthus emblica and is popularly used to prevent or treat various age related health conditions. Telomerase activity in the cells maintains telomere length and is implicated in ageing and various diseases wherein the shortening of telomere during ageing is controlled chiefly by the telomerase activity. Objective In the present study, we investigated telomerase activity and telomere length in the peripheral blood mononuclear cells of aged individuals administered with Amalaki Rasayana. Materials and methods Amalaki Rasayana was administered to healthy, aged (45–60 years) volunteers for 45 days after koshta shuddhi procedure. The telomerase activity and telomere length were analyzed on 0, 45th and 90th days of Amalaki Rasayana administration in peripheral blood mononuclear cells from these individuals and compared with age-matched placebo group and young volunteers (22–30 years). The data were compared between the groups. Results The results indicated an increase in telomerase activity with no discernible change in telomere length in the Amalaki administered participants. The comparison between young and aged participants revealed higher telomerase activity in young participants with no significant differences in telomere length. Conclusion The data indicate that the maintenance of telomere length is facilitated by an increase in telomerase activity upon rasayana administration in aged individuals and Amalaki Rasayana may prevent the erosion of telomeres over a period of time in aged individuals to promote healthy ageing.

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalJournal of Ayurveda and Integrative Medicine
Volume8
Issue number2
DOIs
Publication statusPublished - 01-04-2017

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Telomerase
Telomere
Blood Cells
Volunteers
Phyllanthus emblica
Telomere Homeostasis
Telomere Shortening
Traditional Medicine
Amalakirasayana
Fruit
Research Design
Placebos
Quality of Life
Health

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Guruprasad, Kanive P. ; Dash, Sweta ; Shivakumar, Marigowda B. ; Shetty, Pavithra R. ; Raghu, Kothanahalli S. ; Shamprasad, Bhanuvalli R. ; Udupi, Vishwanatha ; Acharya, Raviraj V. ; Vidya, Prasanna B. ; Nayak, Jayakrishna ; Mana, Anandan E. ; Moni, Rajesh ; Sankaran, Muraleedharan T. ; Satyamoorthy, Kapaettu. / Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells. In: Journal of Ayurveda and Integrative Medicine. 2017 ; Vol. 8, No. 2. pp. 105-112.
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abstract = "Background Indian traditional medicine practices use defined rasayana preparations to improve the quality of life in aged individuals. Amalaki Rasayana is one such rasayana prepared from the fruits of Phyllanthus emblica and is popularly used to prevent or treat various age related health conditions. Telomerase activity in the cells maintains telomere length and is implicated in ageing and various diseases wherein the shortening of telomere during ageing is controlled chiefly by the telomerase activity. Objective In the present study, we investigated telomerase activity and telomere length in the peripheral blood mononuclear cells of aged individuals administered with Amalaki Rasayana. Materials and methods Amalaki Rasayana was administered to healthy, aged (45–60 years) volunteers for 45 days after koshta shuddhi procedure. The telomerase activity and telomere length were analyzed on 0, 45th and 90th days of Amalaki Rasayana administration in peripheral blood mononuclear cells from these individuals and compared with age-matched placebo group and young volunteers (22–30 years). The data were compared between the groups. Results The results indicated an increase in telomerase activity with no discernible change in telomere length in the Amalaki administered participants. The comparison between young and aged participants revealed higher telomerase activity in young participants with no significant differences in telomere length. Conclusion The data indicate that the maintenance of telomere length is facilitated by an increase in telomerase activity upon rasayana administration in aged individuals and Amalaki Rasayana may prevent the erosion of telomeres over a period of time in aged individuals to promote healthy ageing.",
author = "Guruprasad, {Kanive P.} and Sweta Dash and Shivakumar, {Marigowda B.} and Shetty, {Pavithra R.} and Raghu, {Kothanahalli S.} and Shamprasad, {Bhanuvalli R.} and Vishwanatha Udupi and Acharya, {Raviraj V.} and Vidya, {Prasanna B.} and Jayakrishna Nayak and Mana, {Anandan E.} and Rajesh Moni and Sankaran, {Muraleedharan T.} and Kapaettu Satyamoorthy",
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Guruprasad, KP, Dash, S, Shivakumar, MB, Shetty, PR, Raghu, KS, Shamprasad, BR, Udupi, V, Acharya, RV, Vidya, PB, Nayak, J, Mana, AE, Moni, R, Sankaran, MT & Satyamoorthy, K 2017, 'Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells', Journal of Ayurveda and Integrative Medicine, vol. 8, no. 2, pp. 105-112. https://doi.org/10.1016/j.jaim.2017.01.007

Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells. / Guruprasad, Kanive P.; Dash, Sweta; Shivakumar, Marigowda B.; Shetty, Pavithra R.; Raghu, Kothanahalli S.; Shamprasad, Bhanuvalli R.; Udupi, Vishwanatha; Acharya, Raviraj V.; Vidya, Prasanna B.; Nayak, Jayakrishna; Mana, Anandan E.; Moni, Rajesh; Sankaran, Muraleedharan T.; Satyamoorthy, Kapaettu.

In: Journal of Ayurveda and Integrative Medicine, Vol. 8, No. 2, 01.04.2017, p. 105-112.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells

AU - Guruprasad, Kanive P.

AU - Dash, Sweta

AU - Shivakumar, Marigowda B.

AU - Shetty, Pavithra R.

AU - Raghu, Kothanahalli S.

AU - Shamprasad, Bhanuvalli R.

AU - Udupi, Vishwanatha

AU - Acharya, Raviraj V.

AU - Vidya, Prasanna B.

AU - Nayak, Jayakrishna

AU - Mana, Anandan E.

AU - Moni, Rajesh

AU - Sankaran, Muraleedharan T.

AU - Satyamoorthy, Kapaettu

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Background Indian traditional medicine practices use defined rasayana preparations to improve the quality of life in aged individuals. Amalaki Rasayana is one such rasayana prepared from the fruits of Phyllanthus emblica and is popularly used to prevent or treat various age related health conditions. Telomerase activity in the cells maintains telomere length and is implicated in ageing and various diseases wherein the shortening of telomere during ageing is controlled chiefly by the telomerase activity. Objective In the present study, we investigated telomerase activity and telomere length in the peripheral blood mononuclear cells of aged individuals administered with Amalaki Rasayana. Materials and methods Amalaki Rasayana was administered to healthy, aged (45–60 years) volunteers for 45 days after koshta shuddhi procedure. The telomerase activity and telomere length were analyzed on 0, 45th and 90th days of Amalaki Rasayana administration in peripheral blood mononuclear cells from these individuals and compared with age-matched placebo group and young volunteers (22–30 years). The data were compared between the groups. Results The results indicated an increase in telomerase activity with no discernible change in telomere length in the Amalaki administered participants. The comparison between young and aged participants revealed higher telomerase activity in young participants with no significant differences in telomere length. Conclusion The data indicate that the maintenance of telomere length is facilitated by an increase in telomerase activity upon rasayana administration in aged individuals and Amalaki Rasayana may prevent the erosion of telomeres over a period of time in aged individuals to promote healthy ageing.

AB - Background Indian traditional medicine practices use defined rasayana preparations to improve the quality of life in aged individuals. Amalaki Rasayana is one such rasayana prepared from the fruits of Phyllanthus emblica and is popularly used to prevent or treat various age related health conditions. Telomerase activity in the cells maintains telomere length and is implicated in ageing and various diseases wherein the shortening of telomere during ageing is controlled chiefly by the telomerase activity. Objective In the present study, we investigated telomerase activity and telomere length in the peripheral blood mononuclear cells of aged individuals administered with Amalaki Rasayana. Materials and methods Amalaki Rasayana was administered to healthy, aged (45–60 years) volunteers for 45 days after koshta shuddhi procedure. The telomerase activity and telomere length were analyzed on 0, 45th and 90th days of Amalaki Rasayana administration in peripheral blood mononuclear cells from these individuals and compared with age-matched placebo group and young volunteers (22–30 years). The data were compared between the groups. Results The results indicated an increase in telomerase activity with no discernible change in telomere length in the Amalaki administered participants. The comparison between young and aged participants revealed higher telomerase activity in young participants with no significant differences in telomere length. Conclusion The data indicate that the maintenance of telomere length is facilitated by an increase in telomerase activity upon rasayana administration in aged individuals and Amalaki Rasayana may prevent the erosion of telomeres over a period of time in aged individuals to promote healthy ageing.

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