Recent research is probing in to association between poor prognosis of cancer and vagal nerve activity. To investigate the influence of severity of cancer on Indices of vagal function namely E:I ratio and r-MSSD. 184 patients with solid malignant tumor and 150 controls were studied. Severity of cancer was defined based on the TNM staging. Accordingly study subjects were divided into: Early stage (TNM Stage I and II combined) and Advanced stage (TNM stage III and IV combined). E: I ratio during deep breathing and r-MSSD during resting were determined from one minute lead II electrocardiogram. Data was analyzed using Students unpaired t, Mann-Whitney U statistic and Kruskal Wallis tests. p value < 0.05 considered significant. Results: E:I ratio, r-MSSD was lower in cancer patients compared to control (p < 0.0001). E:I ratio and r-MSSD was lower in cancer patients with early and advanced stage of cancer compared to control (p < 0.0001). In study subjects E:I ratio and r-MSSD was lower in advanced stage compared to early stage (p < 0.05; 0.0001, respectively). Vagal function is reduced in cancer patients compared to healthy subjects. Severity of cancer affects vagal activity.
|Number of pages||6|
|Journal||Research Journal of Pharmaceutical, Biological and Chemical Sciences|
|Publication status||Published - 01-01-2016|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)