Influence of cancer and its severity on vagal nerve activity assessed by time domain measures of heart rate variability

Shilpa N. Bijoor, N. K. Subbalakshmi, Sourjya Banerjee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Recent research is probing in to association between poor prognosis of cancer and vagal nerve activity. To investigate the influence of severity of cancer on Indices of vagal function namely E:I ratio and r-MSSD. 184 patients with solid malignant tumor and 150 controls were studied. Severity of cancer was defined based on the TNM staging. Accordingly study subjects were divided into: Early stage (TNM Stage I and II combined) and Advanced stage (TNM stage III and IV combined). E: I ratio during deep breathing and r-MSSD during resting were determined from one minute lead II electrocardiogram. Data was analyzed using Students unpaired t, Mann-Whitney U statistic and Kruskal Wallis tests. p value < 0.05 considered significant. Results: E:I ratio, r-MSSD was lower in cancer patients compared to control (p < 0.0001). E:I ratio and r-MSSD was lower in cancer patients with early and advanced stage of cancer compared to control (p < 0.0001). In study subjects E:I ratio and r-MSSD was lower in advanced stage compared to early stage (p < 0.05; 0.0001, respectively). Vagal function is reduced in cancer patients compared to healthy subjects. Severity of cancer affects vagal activity.

Original languageEnglish
Pages (from-to)1215-1220
Number of pages6
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume7
Issue number3
Publication statusPublished - 01-01-2016

Fingerprint

Heart Rate
Neoplasms
Electrocardiography
Tumors
Statistics
Students
Neoplasm Staging
Healthy Volunteers
Respiration
Research
Lead

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

@article{472af8bcdc7845cfb154f5c13502bd6e,
title = "Influence of cancer and its severity on vagal nerve activity assessed by time domain measures of heart rate variability",
abstract = "Recent research is probing in to association between poor prognosis of cancer and vagal nerve activity. To investigate the influence of severity of cancer on Indices of vagal function namely E:I ratio and r-MSSD. 184 patients with solid malignant tumor and 150 controls were studied. Severity of cancer was defined based on the TNM staging. Accordingly study subjects were divided into: Early stage (TNM Stage I and II combined) and Advanced stage (TNM stage III and IV combined). E: I ratio during deep breathing and r-MSSD during resting were determined from one minute lead II electrocardiogram. Data was analyzed using Students unpaired t, Mann-Whitney U statistic and Kruskal Wallis tests. p value < 0.05 considered significant. Results: E:I ratio, r-MSSD was lower in cancer patients compared to control (p < 0.0001). E:I ratio and r-MSSD was lower in cancer patients with early and advanced stage of cancer compared to control (p < 0.0001). In study subjects E:I ratio and r-MSSD was lower in advanced stage compared to early stage (p < 0.05; 0.0001, respectively). Vagal function is reduced in cancer patients compared to healthy subjects. Severity of cancer affects vagal activity.",
author = "Bijoor, {Shilpa N.} and Subbalakshmi, {N. K.} and Sourjya Banerjee",
year = "2016",
month = "1",
day = "1",
language = "English",
volume = "7",
pages = "1215--1220",
journal = "Research Journal of Pharmaceutical, Biological and Chemical Sciences",
issn = "0975-8585",
publisher = "RJPBCS",
number = "3",

}

Influence of cancer and its severity on vagal nerve activity assessed by time domain measures of heart rate variability. / Bijoor, Shilpa N.; Subbalakshmi, N. K.; Banerjee, Sourjya.

In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 7, No. 3, 01.01.2016, p. 1215-1220.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Influence of cancer and its severity on vagal nerve activity assessed by time domain measures of heart rate variability

AU - Bijoor, Shilpa N.

AU - Subbalakshmi, N. K.

AU - Banerjee, Sourjya

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Recent research is probing in to association between poor prognosis of cancer and vagal nerve activity. To investigate the influence of severity of cancer on Indices of vagal function namely E:I ratio and r-MSSD. 184 patients with solid malignant tumor and 150 controls were studied. Severity of cancer was defined based on the TNM staging. Accordingly study subjects were divided into: Early stage (TNM Stage I and II combined) and Advanced stage (TNM stage III and IV combined). E: I ratio during deep breathing and r-MSSD during resting were determined from one minute lead II electrocardiogram. Data was analyzed using Students unpaired t, Mann-Whitney U statistic and Kruskal Wallis tests. p value < 0.05 considered significant. Results: E:I ratio, r-MSSD was lower in cancer patients compared to control (p < 0.0001). E:I ratio and r-MSSD was lower in cancer patients with early and advanced stage of cancer compared to control (p < 0.0001). In study subjects E:I ratio and r-MSSD was lower in advanced stage compared to early stage (p < 0.05; 0.0001, respectively). Vagal function is reduced in cancer patients compared to healthy subjects. Severity of cancer affects vagal activity.

AB - Recent research is probing in to association between poor prognosis of cancer and vagal nerve activity. To investigate the influence of severity of cancer on Indices of vagal function namely E:I ratio and r-MSSD. 184 patients with solid malignant tumor and 150 controls were studied. Severity of cancer was defined based on the TNM staging. Accordingly study subjects were divided into: Early stage (TNM Stage I and II combined) and Advanced stage (TNM stage III and IV combined). E: I ratio during deep breathing and r-MSSD during resting were determined from one minute lead II electrocardiogram. Data was analyzed using Students unpaired t, Mann-Whitney U statistic and Kruskal Wallis tests. p value < 0.05 considered significant. Results: E:I ratio, r-MSSD was lower in cancer patients compared to control (p < 0.0001). E:I ratio and r-MSSD was lower in cancer patients with early and advanced stage of cancer compared to control (p < 0.0001). In study subjects E:I ratio and r-MSSD was lower in advanced stage compared to early stage (p < 0.05; 0.0001, respectively). Vagal function is reduced in cancer patients compared to healthy subjects. Severity of cancer affects vagal activity.

UR - http://www.scopus.com/inward/record.url?scp=84973346038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973346038&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84973346038

VL - 7

SP - 1215

EP - 1220

JO - Research Journal of Pharmaceutical, Biological and Chemical Sciences

JF - Research Journal of Pharmaceutical, Biological and Chemical Sciences

SN - 0975-8585

IS - 3

ER -