Influence of ethanolic extract of Jasminum grandflorum linn flower on wound healing activity in rats

Shivananda B. Nayak, Krishna Mohan

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The influence of flower extract of Jasminum grandiflorum was studied for its wound healing activity at a dose of 250 mg/kg body weight, using excision and dead space wound models in rats. The animals were divided into three groups in excision wound model, the controls (n=10) were treated with 0.25% CM cellulose, reference standard (n=10) were treated with sulfathiazole ointment and the experimental (n=10) were treated with extract of J. grandiflorum flower till complete epithelialization. The animals in dead space wound models were divided into two groups, controls were given plain drinking water and the experimental animals were administered with extract orally for 10 days. The extract treated wounds were found to epithelize faster as compared to controls. Extracttreated rats exhibited 65% reduction in the wound area when compared to controls (54%). The wet and dry granulation tissue weight, and hydroxyproline content in a dead space wound model increased significantly (P<0.001) when compared to controls. Histological studies of the tissue obtained on day 10 from the extract-treated group showed increased well organized bands of collagen, more fibroblasts and few inflammatory cells when compared to controls which showed inflammatory cells, scanty collagen fibres and fibroblasts. The demonstration of increased rate of wound contraction together with the biochemical and histological findings suggest the use of J. grandiflorum flower extract in the management of wound healing.

Original languageEnglish
Pages (from-to)189-194
Number of pages6
JournalIndian Journal of Physiology and Pharmacology
Volume51
Issue number2
Publication statusPublished - 01-04-2007
Externally publishedYes

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Jasminum
Wound Healing
Space Simulation
Wounds and Injuries
Collagen
Fibroblasts
Granulation Tissue
Hydroxyproline
Ointments
Cellulose
Drinking Water
Body Weight
Weights and Measures
Control Groups

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology

Cite this

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abstract = "The influence of flower extract of Jasminum grandiflorum was studied for its wound healing activity at a dose of 250 mg/kg body weight, using excision and dead space wound models in rats. The animals were divided into three groups in excision wound model, the controls (n=10) were treated with 0.25{\%} CM cellulose, reference standard (n=10) were treated with sulfathiazole ointment and the experimental (n=10) were treated with extract of J. grandiflorum flower till complete epithelialization. The animals in dead space wound models were divided into two groups, controls were given plain drinking water and the experimental animals were administered with extract orally for 10 days. The extract treated wounds were found to epithelize faster as compared to controls. Extracttreated rats exhibited 65{\%} reduction in the wound area when compared to controls (54{\%}). The wet and dry granulation tissue weight, and hydroxyproline content in a dead space wound model increased significantly (P<0.001) when compared to controls. Histological studies of the tissue obtained on day 10 from the extract-treated group showed increased well organized bands of collagen, more fibroblasts and few inflammatory cells when compared to controls which showed inflammatory cells, scanty collagen fibres and fibroblasts. The demonstration of increased rate of wound contraction together with the biochemical and histological findings suggest the use of J. grandiflorum flower extract in the management of wound healing.",
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Influence of ethanolic extract of Jasminum grandflorum linn flower on wound healing activity in rats. / Nayak, Shivananda B.; Mohan, Krishna.

In: Indian Journal of Physiology and Pharmacology, Vol. 51, No. 2, 01.04.2007, p. 189-194.

Research output: Contribution to journalArticle

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