Influence of grape seed extract and Zincovit tablets (nutritional food supplement) on glucose level in normal and streptozocin induced diabetic rats

Shakta Mani Satyam, K. L. Bairy, Rajadurai Pirasanthan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To evaluate the influence of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) on blood glucose level in normal and streptozocin induced diabetic rats. Method: A total of 48 adult male Wistar rats (24 normal rats, 24 diabetic surviving rats) were divided into 8 groups of 6 rats each. Experimental hyperglycemia was produced in rats by single dose of Streptozocin (35 mg/kg; i.p). Assessment of glucose in blood and urine of rats was used as marker of hyperglycemia. Results: Oral administration of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) for 45 days significantly reduced the levels of blood glucose in a dose dependent manner among diabetic treated rats when compared to diabetic control rats (P<0.0001, at 40 mg/kg, 80 mg/kg and 160 mg/kg) whereas it had significantly increased the blood glucose level in normal treated rats in comparison with normal control rats (P=0.011, 0.003 and 0.029 at 40 mg/kg, 80 mg/kg and 160 mg/kg respectively). There was significant increase in the weight of isolated dry liver among diabetic treatment group when compared to diabetic control in a dose dependent manner. There was no significant body weight change in diabetic and normal rats as compared to diabetic control and normal control rats respectively. Conclusion: The hypoglycemic effect of combination of Grape seed extract and Zincovit tablets may be attributed to enhanced antioxidant potential and protection against tissue lipid peroxidation and protein oxidation.

Original languageEnglish
Pages (from-to)413-416
Number of pages4
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume5
Issue numberSUPPL 3
Publication statusPublished - 28-08-2013

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Grape Seed Extract
Streptozocin
Dietary Supplements
Tablets
Glucose
Blood Glucose
Hyperglycemia
Body Weight Changes
Hypoglycemic Agents
Lipid Peroxidation

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

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title = "Influence of grape seed extract and Zincovit tablets (nutritional food supplement) on glucose level in normal and streptozocin induced diabetic rats",
abstract = "Objective: To evaluate the influence of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) on blood glucose level in normal and streptozocin induced diabetic rats. Method: A total of 48 adult male Wistar rats (24 normal rats, 24 diabetic surviving rats) were divided into 8 groups of 6 rats each. Experimental hyperglycemia was produced in rats by single dose of Streptozocin (35 mg/kg; i.p). Assessment of glucose in blood and urine of rats was used as marker of hyperglycemia. Results: Oral administration of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) for 45 days significantly reduced the levels of blood glucose in a dose dependent manner among diabetic treated rats when compared to diabetic control rats (P<0.0001, at 40 mg/kg, 80 mg/kg and 160 mg/kg) whereas it had significantly increased the blood glucose level in normal treated rats in comparison with normal control rats (P=0.011, 0.003 and 0.029 at 40 mg/kg, 80 mg/kg and 160 mg/kg respectively). There was significant increase in the weight of isolated dry liver among diabetic treatment group when compared to diabetic control in a dose dependent manner. There was no significant body weight change in diabetic and normal rats as compared to diabetic control and normal control rats respectively. Conclusion: The hypoglycemic effect of combination of Grape seed extract and Zincovit tablets may be attributed to enhanced antioxidant potential and protection against tissue lipid peroxidation and protein oxidation.",
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T1 - Influence of grape seed extract and Zincovit tablets (nutritional food supplement) on glucose level in normal and streptozocin induced diabetic rats

AU - Mani Satyam, Shakta

AU - Bairy, K. L.

AU - Pirasanthan, Rajadurai

PY - 2013/8/28

Y1 - 2013/8/28

N2 - Objective: To evaluate the influence of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) on blood glucose level in normal and streptozocin induced diabetic rats. Method: A total of 48 adult male Wistar rats (24 normal rats, 24 diabetic surviving rats) were divided into 8 groups of 6 rats each. Experimental hyperglycemia was produced in rats by single dose of Streptozocin (35 mg/kg; i.p). Assessment of glucose in blood and urine of rats was used as marker of hyperglycemia. Results: Oral administration of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) for 45 days significantly reduced the levels of blood glucose in a dose dependent manner among diabetic treated rats when compared to diabetic control rats (P<0.0001, at 40 mg/kg, 80 mg/kg and 160 mg/kg) whereas it had significantly increased the blood glucose level in normal treated rats in comparison with normal control rats (P=0.011, 0.003 and 0.029 at 40 mg/kg, 80 mg/kg and 160 mg/kg respectively). There was significant increase in the weight of isolated dry liver among diabetic treatment group when compared to diabetic control in a dose dependent manner. There was no significant body weight change in diabetic and normal rats as compared to diabetic control and normal control rats respectively. Conclusion: The hypoglycemic effect of combination of Grape seed extract and Zincovit tablets may be attributed to enhanced antioxidant potential and protection against tissue lipid peroxidation and protein oxidation.

AB - Objective: To evaluate the influence of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) on blood glucose level in normal and streptozocin induced diabetic rats. Method: A total of 48 adult male Wistar rats (24 normal rats, 24 diabetic surviving rats) were divided into 8 groups of 6 rats each. Experimental hyperglycemia was produced in rats by single dose of Streptozocin (35 mg/kg; i.p). Assessment of glucose in blood and urine of rats was used as marker of hyperglycemia. Results: Oral administration of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) for 45 days significantly reduced the levels of blood glucose in a dose dependent manner among diabetic treated rats when compared to diabetic control rats (P<0.0001, at 40 mg/kg, 80 mg/kg and 160 mg/kg) whereas it had significantly increased the blood glucose level in normal treated rats in comparison with normal control rats (P=0.011, 0.003 and 0.029 at 40 mg/kg, 80 mg/kg and 160 mg/kg respectively). There was significant increase in the weight of isolated dry liver among diabetic treatment group when compared to diabetic control in a dose dependent manner. There was no significant body weight change in diabetic and normal rats as compared to diabetic control and normal control rats respectively. Conclusion: The hypoglycemic effect of combination of Grape seed extract and Zincovit tablets may be attributed to enhanced antioxidant potential and protection against tissue lipid peroxidation and protein oxidation.

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