Influence of obesity on first trimester screening markers in singleton pregnant women enrolled at tertiary care hospital

B. S. Varashree, Vijetha Shenoy Belle, R. V. Krishnananda Prabhu, Pragna Rao

Research output: Contribution to journalArticle

Abstract

Pregnancy is diagnosed by the detection of beta human Chorionic Gonadotropin (beta hCG) in maternal serum or urine after implantation of the embryo. Primary function of hCG is to maintain the corpus luteum in early weeks of gestation. Pregnancy associated plasma protein A is a glycoprotein exhibits insulin like growth factor binding protein 4 protease activity, which regulates bioavailability of Insulin like Growth Factor-II. Maternal obesity increases the likelihood of serious pregnancy complications both for mother and infant. The altered maternal environment in women with a raised BMI could have adverse consequences for placental development and function thus we hypothesized if maternal body mass index is associated with alterations in serum levels of free β- HCG and PAPP-A After obtaining approval from institutional ethics committee, Kasturba Hospital Manipal, 676 singleton pregnant women of 19-45 years, in 10-14 weeks of gestations were enrolled for the study. Serum free beta hCG and PAPP-A by ECLIA method. BMI was calculated using the formula weight (in kgs)/height in m2. Data were compiled, statistical analysis was done. Non parametric tests were used for analysis. Median and MoM levels of both free beta hCG and PAPP-A showed a significant negative correlation with BMI (p<0.001). To conclude obese women have a larger extracellular volume, larger distribution volume for hCG and PAPPA. Low hCG in women with high BMI may be sequestration of hCG by adipose tissue-resident macrophages. Inverse association of HCG concentration with BMI may be a result of impaired synthesis of HCG in obese women.

Original languageEnglish
Pages (from-to)148-151
Number of pages4
JournalMalaysian Journal of Biochemistry and Molecular Biology
Volume22
Issue number1
Publication statusPublished - 01-01-2019

Fingerprint

Pregnancy-Associated Plasma Protein-A
Tertiary Healthcare
First Pregnancy Trimester
Tertiary Care Centers
Pregnant Women
Screening
Obesity
Mothers
Chorionic Gonadotropin
Pregnancy
Serum
Placentation
Ethics Committees
Insulin-Like Growth Factor II
Pregnancy Complications
Macrophages
Corpus Luteum
Biological Availability
Adipose Tissue
Statistical methods

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

@article{007dc3e5b9a44f17af821c76cf61ad11,
title = "Influence of obesity on first trimester screening markers in singleton pregnant women enrolled at tertiary care hospital",
abstract = "Pregnancy is diagnosed by the detection of beta human Chorionic Gonadotropin (beta hCG) in maternal serum or urine after implantation of the embryo. Primary function of hCG is to maintain the corpus luteum in early weeks of gestation. Pregnancy associated plasma protein A is a glycoprotein exhibits insulin like growth factor binding protein 4 protease activity, which regulates bioavailability of Insulin like Growth Factor-II. Maternal obesity increases the likelihood of serious pregnancy complications both for mother and infant. The altered maternal environment in women with a raised BMI could have adverse consequences for placental development and function thus we hypothesized if maternal body mass index is associated with alterations in serum levels of free β- HCG and PAPP-A After obtaining approval from institutional ethics committee, Kasturba Hospital Manipal, 676 singleton pregnant women of 19-45 years, in 10-14 weeks of gestations were enrolled for the study. Serum free beta hCG and PAPP-A by ECLIA method. BMI was calculated using the formula weight (in kgs)/height in m2. Data were compiled, statistical analysis was done. Non parametric tests were used for analysis. Median and MoM levels of both free beta hCG and PAPP-A showed a significant negative correlation with BMI (p<0.001). To conclude obese women have a larger extracellular volume, larger distribution volume for hCG and PAPPA. Low hCG in women with high BMI may be sequestration of hCG by adipose tissue-resident macrophages. Inverse association of HCG concentration with BMI may be a result of impaired synthesis of HCG in obese women.",
author = "Varashree, {B. S.} and Belle, {Vijetha Shenoy} and {Krishnananda Prabhu}, {R. V.} and Pragna Rao",
year = "2019",
month = "1",
day = "1",
language = "English",
volume = "22",
pages = "148--151",
journal = "Malaysian Journal of Biochemistry and Molecular Biology",
issn = "1511-2616",
publisher = "Malaysian Society for Biochemistry and Molecular Biology",
number = "1",

}

TY - JOUR

T1 - Influence of obesity on first trimester screening markers in singleton pregnant women enrolled at tertiary care hospital

AU - Varashree, B. S.

AU - Belle, Vijetha Shenoy

AU - Krishnananda Prabhu, R. V.

AU - Rao, Pragna

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Pregnancy is diagnosed by the detection of beta human Chorionic Gonadotropin (beta hCG) in maternal serum or urine after implantation of the embryo. Primary function of hCG is to maintain the corpus luteum in early weeks of gestation. Pregnancy associated plasma protein A is a glycoprotein exhibits insulin like growth factor binding protein 4 protease activity, which regulates bioavailability of Insulin like Growth Factor-II. Maternal obesity increases the likelihood of serious pregnancy complications both for mother and infant. The altered maternal environment in women with a raised BMI could have adverse consequences for placental development and function thus we hypothesized if maternal body mass index is associated with alterations in serum levels of free β- HCG and PAPP-A After obtaining approval from institutional ethics committee, Kasturba Hospital Manipal, 676 singleton pregnant women of 19-45 years, in 10-14 weeks of gestations were enrolled for the study. Serum free beta hCG and PAPP-A by ECLIA method. BMI was calculated using the formula weight (in kgs)/height in m2. Data were compiled, statistical analysis was done. Non parametric tests were used for analysis. Median and MoM levels of both free beta hCG and PAPP-A showed a significant negative correlation with BMI (p<0.001). To conclude obese women have a larger extracellular volume, larger distribution volume for hCG and PAPPA. Low hCG in women with high BMI may be sequestration of hCG by adipose tissue-resident macrophages. Inverse association of HCG concentration with BMI may be a result of impaired synthesis of HCG in obese women.

AB - Pregnancy is diagnosed by the detection of beta human Chorionic Gonadotropin (beta hCG) in maternal serum or urine after implantation of the embryo. Primary function of hCG is to maintain the corpus luteum in early weeks of gestation. Pregnancy associated plasma protein A is a glycoprotein exhibits insulin like growth factor binding protein 4 protease activity, which regulates bioavailability of Insulin like Growth Factor-II. Maternal obesity increases the likelihood of serious pregnancy complications both for mother and infant. The altered maternal environment in women with a raised BMI could have adverse consequences for placental development and function thus we hypothesized if maternal body mass index is associated with alterations in serum levels of free β- HCG and PAPP-A After obtaining approval from institutional ethics committee, Kasturba Hospital Manipal, 676 singleton pregnant women of 19-45 years, in 10-14 weeks of gestations were enrolled for the study. Serum free beta hCG and PAPP-A by ECLIA method. BMI was calculated using the formula weight (in kgs)/height in m2. Data were compiled, statistical analysis was done. Non parametric tests were used for analysis. Median and MoM levels of both free beta hCG and PAPP-A showed a significant negative correlation with BMI (p<0.001). To conclude obese women have a larger extracellular volume, larger distribution volume for hCG and PAPPA. Low hCG in women with high BMI may be sequestration of hCG by adipose tissue-resident macrophages. Inverse association of HCG concentration with BMI may be a result of impaired synthesis of HCG in obese women.

UR - http://www.scopus.com/inward/record.url?scp=85071935988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071935988&partnerID=8YFLogxK

M3 - Article

VL - 22

SP - 148

EP - 151

JO - Malaysian Journal of Biochemistry and Molecular Biology

JF - Malaysian Journal of Biochemistry and Molecular Biology

SN - 1511-2616

IS - 1

ER -