Influence of topical retapamulin (1%) ointment, Sofinox- RD cream, Sofinox cream (2%), Zinc fusidate cream (2%) and zinc fusidate ointment (2%) on nasal mucosal surface safety in New Zealand albino rabbits

Shakta Mani Satyam, K. Laxminarayana Bairy, Rajadurai Pirasanthan, Rajdip Lalit Vaishnav, Sonal Kashyap

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To investigate the comparative safety of Retapamulin 1% ointment, Sodium fusidate 0.25%, Sofinox 2% cream, Zinc fusidate 2% cream and Zinc fusidate 2% ointment on nasal mucosal surface in rabbits. Methods: In the experiment a total of 30 adult New Zealand albino rabbits of either sex were used. The rabbits were divided into five groups of six rabbits each. A thin layer of the drug was applied in the right nostril and left nostril was kept as control (no treatment) to their corresponding treatment group. Nasal safety of these drugs was assessed with the help of a symptom scoring system and photographic observations. Results: There was significant decrease of nasal rubbing (Rhinocnesmus) behaviors in experimental animals of Sofinox RD cream (p<0.001), Sofinox 2% cream (p<0.001), Zinc fusidate cream (p<0.001) and Zinc fusidate ointment (p<0.001) treated groups when compared with Retapamulin 1% ointment treated group. More redness was observed in nasal mucosal surface of both nostrils (Right nostril- Retapamulin 1% ointment, Left nostril- Control) of Retapamulin group animals in comparison with Sofinox RD cream, Sofinox 2% cream, Zinc fusidate 2% cream and Zinc fusidate 2% ointment group animals. Conclusion: In the present study, the comparative safety of test drugs on nasal mucosal surface of rabbits were found as- Zinc fusidate ointment > Zinc fusidate cream > Sofinox RD cream ~ Sofinox 2% cream > Retapamulin 1% ointment. Further, clinical evaluation has to be performed to precisely define the safety of Zinc fusidate ointment, Zinc fusidate cream, Sofinox RD cream and Sofinox 2% cream on nasal mucosal surface of human subjects.

Original languageEnglish
Pages (from-to)183-186
Number of pages4
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume7
Issue number2
Publication statusPublished - 2015

Fingerprint

Ointments
Nose
Zinc
Rabbits
Safety
Fusidic Acid
Pharmaceutical Preparations
retapamulin

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

@article{94d1cd97bfe44cc29c1522c4de38e4d7,
title = "Influence of topical retapamulin (1{\%}) ointment, Sofinox- RD cream, Sofinox cream (2{\%}), Zinc fusidate cream (2{\%}) and zinc fusidate ointment (2{\%}) on nasal mucosal surface safety in New Zealand albino rabbits",
abstract = "Objective: To investigate the comparative safety of Retapamulin 1{\%} ointment, Sodium fusidate 0.25{\%}, Sofinox 2{\%} cream, Zinc fusidate 2{\%} cream and Zinc fusidate 2{\%} ointment on nasal mucosal surface in rabbits. Methods: In the experiment a total of 30 adult New Zealand albino rabbits of either sex were used. The rabbits were divided into five groups of six rabbits each. A thin layer of the drug was applied in the right nostril and left nostril was kept as control (no treatment) to their corresponding treatment group. Nasal safety of these drugs was assessed with the help of a symptom scoring system and photographic observations. Results: There was significant decrease of nasal rubbing (Rhinocnesmus) behaviors in experimental animals of Sofinox RD cream (p<0.001), Sofinox 2{\%} cream (p<0.001), Zinc fusidate cream (p<0.001) and Zinc fusidate ointment (p<0.001) treated groups when compared with Retapamulin 1{\%} ointment treated group. More redness was observed in nasal mucosal surface of both nostrils (Right nostril- Retapamulin 1{\%} ointment, Left nostril- Control) of Retapamulin group animals in comparison with Sofinox RD cream, Sofinox 2{\%} cream, Zinc fusidate 2{\%} cream and Zinc fusidate 2{\%} ointment group animals. Conclusion: In the present study, the comparative safety of test drugs on nasal mucosal surface of rabbits were found as- Zinc fusidate ointment > Zinc fusidate cream > Sofinox RD cream ~ Sofinox 2{\%} cream > Retapamulin 1{\%} ointment. Further, clinical evaluation has to be performed to precisely define the safety of Zinc fusidate ointment, Zinc fusidate cream, Sofinox RD cream and Sofinox 2{\%} cream on nasal mucosal surface of human subjects.",
author = "Satyam, {Shakta Mani} and {Laxminarayana Bairy}, K. and Rajadurai Pirasanthan and Vaishnav, {Rajdip Lalit} and Sonal Kashyap",
year = "2015",
language = "English",
volume = "7",
pages = "183--186",
journal = "International Journal of Pharmacy and Pharmaceutical Sciences",
issn = "0975-1491",
publisher = "IJPPS",
number = "2",

}

TY - JOUR

T1 - Influence of topical retapamulin (1%) ointment, Sofinox- RD cream, Sofinox cream (2%), Zinc fusidate cream (2%) and zinc fusidate ointment (2%) on nasal mucosal surface safety in New Zealand albino rabbits

AU - Satyam, Shakta Mani

AU - Laxminarayana Bairy, K.

AU - Pirasanthan, Rajadurai

AU - Vaishnav, Rajdip Lalit

AU - Kashyap, Sonal

PY - 2015

Y1 - 2015

N2 - Objective: To investigate the comparative safety of Retapamulin 1% ointment, Sodium fusidate 0.25%, Sofinox 2% cream, Zinc fusidate 2% cream and Zinc fusidate 2% ointment on nasal mucosal surface in rabbits. Methods: In the experiment a total of 30 adult New Zealand albino rabbits of either sex were used. The rabbits were divided into five groups of six rabbits each. A thin layer of the drug was applied in the right nostril and left nostril was kept as control (no treatment) to their corresponding treatment group. Nasal safety of these drugs was assessed with the help of a symptom scoring system and photographic observations. Results: There was significant decrease of nasal rubbing (Rhinocnesmus) behaviors in experimental animals of Sofinox RD cream (p<0.001), Sofinox 2% cream (p<0.001), Zinc fusidate cream (p<0.001) and Zinc fusidate ointment (p<0.001) treated groups when compared with Retapamulin 1% ointment treated group. More redness was observed in nasal mucosal surface of both nostrils (Right nostril- Retapamulin 1% ointment, Left nostril- Control) of Retapamulin group animals in comparison with Sofinox RD cream, Sofinox 2% cream, Zinc fusidate 2% cream and Zinc fusidate 2% ointment group animals. Conclusion: In the present study, the comparative safety of test drugs on nasal mucosal surface of rabbits were found as- Zinc fusidate ointment > Zinc fusidate cream > Sofinox RD cream ~ Sofinox 2% cream > Retapamulin 1% ointment. Further, clinical evaluation has to be performed to precisely define the safety of Zinc fusidate ointment, Zinc fusidate cream, Sofinox RD cream and Sofinox 2% cream on nasal mucosal surface of human subjects.

AB - Objective: To investigate the comparative safety of Retapamulin 1% ointment, Sodium fusidate 0.25%, Sofinox 2% cream, Zinc fusidate 2% cream and Zinc fusidate 2% ointment on nasal mucosal surface in rabbits. Methods: In the experiment a total of 30 adult New Zealand albino rabbits of either sex were used. The rabbits were divided into five groups of six rabbits each. A thin layer of the drug was applied in the right nostril and left nostril was kept as control (no treatment) to their corresponding treatment group. Nasal safety of these drugs was assessed with the help of a symptom scoring system and photographic observations. Results: There was significant decrease of nasal rubbing (Rhinocnesmus) behaviors in experimental animals of Sofinox RD cream (p<0.001), Sofinox 2% cream (p<0.001), Zinc fusidate cream (p<0.001) and Zinc fusidate ointment (p<0.001) treated groups when compared with Retapamulin 1% ointment treated group. More redness was observed in nasal mucosal surface of both nostrils (Right nostril- Retapamulin 1% ointment, Left nostril- Control) of Retapamulin group animals in comparison with Sofinox RD cream, Sofinox 2% cream, Zinc fusidate 2% cream and Zinc fusidate 2% ointment group animals. Conclusion: In the present study, the comparative safety of test drugs on nasal mucosal surface of rabbits were found as- Zinc fusidate ointment > Zinc fusidate cream > Sofinox RD cream ~ Sofinox 2% cream > Retapamulin 1% ointment. Further, clinical evaluation has to be performed to precisely define the safety of Zinc fusidate ointment, Zinc fusidate cream, Sofinox RD cream and Sofinox 2% cream on nasal mucosal surface of human subjects.

UR - http://www.scopus.com/inward/record.url?scp=84922192902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922192902&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84922192902

VL - 7

SP - 183

EP - 186

JO - International Journal of Pharmacy and Pharmaceutical Sciences

JF - International Journal of Pharmacy and Pharmaceutical Sciences

SN - 0975-1491

IS - 2

ER -