TY - JOUR
T1 - Influence of various concentrations of taxol on cell survival, micronuclei induction, and LDH activity in cultured V79 cells
AU - Jagetia, Ganesh Chandra
AU - Adiga, Satish Kumar
PY - 1995/9/25
Y1 - 1995/9/25
N2 - The clastogenic effect of various concentrations of taxol, namely 0, 10, 25, 50, 100, 250 and 500 nM was evaluated in V79 cells grown in vitro. Treatment of V79 cells with different concentrations of taxol reduced the survival in a concentration dependent manner. However, the frequency of micronuclei increased in a concentration dependent manner and the dose response was linear quadratic. Similarly, lactate dehydrogenase also increased with the increase in taxol concentration. The micronuclei and lactate dehydrogenase showed an inverse relationship with the cell survival.
AB - The clastogenic effect of various concentrations of taxol, namely 0, 10, 25, 50, 100, 250 and 500 nM was evaluated in V79 cells grown in vitro. Treatment of V79 cells with different concentrations of taxol reduced the survival in a concentration dependent manner. However, the frequency of micronuclei increased in a concentration dependent manner and the dose response was linear quadratic. Similarly, lactate dehydrogenase also increased with the increase in taxol concentration. The micronuclei and lactate dehydrogenase showed an inverse relationship with the cell survival.
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U2 - 10.1016/0304-3835(95)03929-Q
DO - 10.1016/0304-3835(95)03929-Q
M3 - Article
C2 - 7585457
AN - SCOPUS:0029112826
SN - 0304-3835
VL - 96
SP - 195
EP - 200
JO - Cancer Letters
JF - Cancer Letters
IS - 2
ER -
