Influence of various concentrations of taxol on cell survival, micronuclei induction, and LDH activity in cultured V79 cells

Ganesh Chandra Jagetia, Satish Kumar Adiga

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The clastogenic effect of various concentrations of taxol, namely 0, 10, 25, 50, 100, 250 and 500 nM was evaluated in V79 cells grown in vitro. Treatment of V79 cells with different concentrations of taxol reduced the survival in a concentration dependent manner. However, the frequency of micronuclei increased in a concentration dependent manner and the dose response was linear quadratic. Similarly, lactate dehydrogenase also increased with the increase in taxol concentration. The micronuclei and lactate dehydrogenase showed an inverse relationship with the cell survival.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalCancer Letters
Volume96
Issue number2
DOIs
Publication statusPublished - 25-09-1995

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology
  • Molecular Biology

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