Influence of zincovit drop (nutritional food supplement) on immune system in normal and cyclophosphamide intoxicated wistar rats

Shakta Mani Satyam, Laxminarayana Bairy Kurady

Research output: Contribution to journalArticle

Abstract

Objective: The aim of the present study was to investigate the influence of Zincovit (ZVT) drop (nutritional food supplement) on the immune system in normal healthy and cyclophosphamide (CP) intoxicated Wistar rats. Methods: The study was carried out in healthy and immunotoxic Wistar rats (CP; 20 mg/kg/day) with ZVT drop (a combined formulation of multivitamin-multimineral, flaxseed oil, and lysine) at the dose of 25 and 50 mg/kg/day for 45 days. Hematological and immunological parameters, such as immunoglobulin (Ig)G, IgM, interferon-γ, interleukin-2, and interleukin-4, were assessed. In addition, histopathological examination of the spleen was also performed. Results: There were no significant changes in all the hematological parameters such as total leukocyte, differential leukocyte, total erythrocyte, and total platelets count, hemoglobin amount and also the immunological parameters such as IgG, IgM, interferon-γ, and interleukin-4 level among the treatment groups except interleukin-2. There was a significant increase in interleukin-2 level in the group of animals treated with ZVT drop at the dose of 25 mg/kg (p<0.001) and 50 mg/kg (p<0.05) in comparison with normal control animals. Conclusion: The present study revealed the immunomodulatory effect of ZVT drop at the dose of 25 and 50 mg/kg/day in normal healthy Wistar rats.

Original languageEnglish
Pages (from-to)238-240
Number of pages3
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume9
Issue number1
Publication statusPublished - 01-01-2016

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Dietary Supplements
Cyclophosphamide
Interleukin-2
Wistar Rats
Immune System
Interleukin-4
Interferons
Immunoglobulin M
Leukocytes
Immunoglobulin G
Linseed Oil
Platelet Count
Lysine
Hemoglobins
Spleen
Erythrocytes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

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title = "Influence of zincovit drop (nutritional food supplement) on immune system in normal and cyclophosphamide intoxicated wistar rats",
abstract = "Objective: The aim of the present study was to investigate the influence of Zincovit (ZVT) drop (nutritional food supplement) on the immune system in normal healthy and cyclophosphamide (CP) intoxicated Wistar rats. Methods: The study was carried out in healthy and immunotoxic Wistar rats (CP; 20 mg/kg/day) with ZVT drop (a combined formulation of multivitamin-multimineral, flaxseed oil, and lysine) at the dose of 25 and 50 mg/kg/day for 45 days. Hematological and immunological parameters, such as immunoglobulin (Ig)G, IgM, interferon-γ, interleukin-2, and interleukin-4, were assessed. In addition, histopathological examination of the spleen was also performed. Results: There were no significant changes in all the hematological parameters such as total leukocyte, differential leukocyte, total erythrocyte, and total platelets count, hemoglobin amount and also the immunological parameters such as IgG, IgM, interferon-γ, and interleukin-4 level among the treatment groups except interleukin-2. There was a significant increase in interleukin-2 level in the group of animals treated with ZVT drop at the dose of 25 mg/kg (p<0.001) and 50 mg/kg (p<0.05) in comparison with normal control animals. Conclusion: The present study revealed the immunomodulatory effect of ZVT drop at the dose of 25 and 50 mg/kg/day in normal healthy Wistar rats.",
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AU - Kurady, Laxminarayana Bairy

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AB - Objective: The aim of the present study was to investigate the influence of Zincovit (ZVT) drop (nutritional food supplement) on the immune system in normal healthy and cyclophosphamide (CP) intoxicated Wistar rats. Methods: The study was carried out in healthy and immunotoxic Wistar rats (CP; 20 mg/kg/day) with ZVT drop (a combined formulation of multivitamin-multimineral, flaxseed oil, and lysine) at the dose of 25 and 50 mg/kg/day for 45 days. Hematological and immunological parameters, such as immunoglobulin (Ig)G, IgM, interferon-γ, interleukin-2, and interleukin-4, were assessed. In addition, histopathological examination of the spleen was also performed. Results: There were no significant changes in all the hematological parameters such as total leukocyte, differential leukocyte, total erythrocyte, and total platelets count, hemoglobin amount and also the immunological parameters such as IgG, IgM, interferon-γ, and interleukin-4 level among the treatment groups except interleukin-2. There was a significant increase in interleukin-2 level in the group of animals treated with ZVT drop at the dose of 25 mg/kg (p<0.001) and 50 mg/kg (p<0.05) in comparison with normal control animals. Conclusion: The present study revealed the immunomodulatory effect of ZVT drop at the dose of 25 and 50 mg/kg/day in normal healthy Wistar rats.

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