Inherent rhythmcity and interstitial cells of Cajal in a frog vein

Dipanwita Ghose, Lingu Jose, S. Manjunatha, Muddanna S. Rao, J. Prakasa Rao

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Interstitial cells of Cajal are responsible for rhythmic contractions of the musculature of the gastrointestinal tract and blood vessels. The existence of these cells and spontaneous rhythmicity were noticed in amphibian vein and the findings are reported in this paper. The postcaval vein was identified in the frog, Rana tigrina and was perfused with amphibian Ringer solution after isolation. Contractile activity was recorded through a tension transducer connected to a polygraph. The isolated postcaval vein showed spontaneous rhythmic activity. Addition of cold Ringer solution decreased, while warm Ringer increased, the rate of contraction. Adrenaline caused inhibition of rhythmic activity at a dosage that increased the rate of isolated sinus venosus. Sections of the postcaval vein, when stained supravitally with methylene blue, showed the presence of interstitial cells of Cajal. Photic stimulation of the vein in the presence of methylene blue led to a significant decrease in the rate of spontaneous beating of the vein. These findings indicate that the postcaval vein of frog is capable of inherent rhythmcity, which is dependent on the interstitial cells of Cajal but is independent of the sinus venosus.

Original languageEnglish
Pages (from-to)755-759
Number of pages5
JournalJournal of Biosciences
Volume33
Issue number5
DOIs
Publication statusPublished - 01-12-2008
Externally publishedYes

Fingerprint

Interstitial Cells of Cajal
Anura
frogs
Veins
Methylene Blue
Cells
methylene blue
sinuses
amphibians
Blood vessels
cells
Amphibians
Epinephrine
Transducers
epinephrine
blood vessels
gastrointestinal system
Ranidae
Photic Stimulation
Periodicity

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Ghose, D., Jose, L., Manjunatha, S., Rao, M. S., & Rao, J. P. (2008). Inherent rhythmcity and interstitial cells of Cajal in a frog vein. Journal of Biosciences, 33(5), 755-759. https://doi.org/10.1007/s12038-008-0095-7
Ghose, Dipanwita ; Jose, Lingu ; Manjunatha, S. ; Rao, Muddanna S. ; Rao, J. Prakasa. / Inherent rhythmcity and interstitial cells of Cajal in a frog vein. In: Journal of Biosciences. 2008 ; Vol. 33, No. 5. pp. 755-759.
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Ghose, D, Jose, L, Manjunatha, S, Rao, MS & Rao, JP 2008, 'Inherent rhythmcity and interstitial cells of Cajal in a frog vein', Journal of Biosciences, vol. 33, no. 5, pp. 755-759. https://doi.org/10.1007/s12038-008-0095-7

Inherent rhythmcity and interstitial cells of Cajal in a frog vein. / Ghose, Dipanwita; Jose, Lingu; Manjunatha, S.; Rao, Muddanna S.; Rao, J. Prakasa.

In: Journal of Biosciences, Vol. 33, No. 5, 01.12.2008, p. 755-759.

Research output: Contribution to journalArticle

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