Inhibition of croton oil-induced oedema in rat ear skin by topical nicotinamide gel

S. M. Satyam, K. L. Bairy, S. Musharraf, D. L. Fernandes

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Abstract

Nicotinamide, a physiologically active form of niacin (nicotinic acid), in combination with zinc is being assessed in clinical studies for the treatment of inflammatory skin diseases such as acne vulgaris and bullous pemphigoid. Consequently the aim of the present study was to investigate the anti-inflammatory effect of Nicotinamide gel 2%, 3% and 4% (Apex Laboratories Private Limited, Chennai, India) against croton oil-induced ear oedema skin inflammatory model in Wistar rats. Ear oedema was induced by topical application of irritant solution of croton oil to the right ear only. A total of 24 Wistar rats were randomly grouped into four groups each containing six animals. Croton oil-induced ear oedema control rats (Group I) and Nicotinamide gel 2% (Group II), 3% (Group III) and 4% (Group IV) dissolved in the irritant solution of croton oil was applied for 21 days. The topical application of Nicotinamide gel significantly reduced the oedema (p<0.001) in comparison with the croton oil applied toxic control group (untreated) at all the three concentrations 2%, 3% and 4%. The present study revealed that the Nicotinamide gel 2%, 3% and 4% (Apex Laboratories Private Limited, Chennai, India) is the potential agent that could offer a novel therapeutic option against croton oil-induced ear edema in Wistar rats.

Original languageEnglish
Pages (from-to)22-25
Number of pages4
JournalPharmacologyonline
Volume3
Publication statusPublished - 30-12-2014

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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