Inhibition of selenium dependent glutathione peroxidase and superoxide dismutase in rats by diethyldithiocarbamate: Effect of pre-administration of α-tocopherol

H. Ramachandra Prabhu, M. Nandini

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1 Citation (Scopus)

Abstract

Rats pre-administered with á-tocopherol (10 mgs/day) for 7 days afforded a significant protection at the tissue level against the lowering of superoxide dismutase and glutathione peroxidase, especially the selenium-dependent glutathione peroxidase. The protective action of á-tocopherol in the diethyldithiocarbamate treated rats may be attributed to its antioxidant/free radical scavenging action. It is concluded that selenium-dependent glutathione peroxidase and á-tocopherol act in a complementary fashion to block free radical formation.

Original languageEnglish
Pages (from-to)465-468
Number of pages4
JournalIndian Journal of Experimental Biology
Volume45
Issue number5
Publication statusPublished - 01-05-2007

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Ditiocarb
Tocopherols
Selenium
Glutathione Peroxidase
Superoxide Dismutase
Free Radicals
Antioxidants

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Biology
  • Cell Biology

Cite this

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abstract = "Rats pre-administered with {\'a}-tocopherol (10 mgs/day) for 7 days afforded a significant protection at the tissue level against the lowering of superoxide dismutase and glutathione peroxidase, especially the selenium-dependent glutathione peroxidase. The protective action of {\'a}-tocopherol in the diethyldithiocarbamate treated rats may be attributed to its antioxidant/free radical scavenging action. It is concluded that selenium-dependent glutathione peroxidase and {\'a}-tocopherol act in a complementary fashion to block free radical formation.",
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