Interactions of polyphenols with plasma proteins

Insights from analytical techniques

Seetharamappa Jaldappagari, Sandhya Balakrishnan, Ashwini H. Hegde, Nagappa L. Teradal, Prashanth S. Narayan

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Phenolic compounds are commonly found in natural sources like plant-based foods and beverages. These compounds have received much attention due to their unique biological properties. Polyphenols possess a significant binding affinity for serum albumins which are known to be principal extracellular proteins with a high concentration in blood plasma. They act as carriers of several drugs to different molecular targets. This review summarizes the salient features of the reported work on polyphenol-protein interactions by analytical methods viz., chromatography, circular dichroism, fluorescence spectroscopy (steady state and time resolved), light scattering, equilibrium dialysis, differential scanning calorimetry, UV-vis spectroscopy, isothermal calorimetry, MALDI-TOF mass spectrometry, size exclusion chromatography, capillary electrophoresis, electrospray ionization mass spectrometry, FT-IR, molecular modelling, HPLC, NMR, cyclic voltammetry etc. Polyphenol-serum albumin interaction studies assume significance from the view point of pharmacokinet-ics and pharmacodynamics.

Original languageEnglish
Pages (from-to)456-473
Number of pages18
JournalCurrent Drug Metabolism
Volume14
Issue number4
DOIs
Publication statusPublished - 01-05-2013

Fingerprint

Polyphenols
Blood Proteins
Serum Albumin
Mass spectrometry
Pharmacodynamics
Food and Beverages
Capillary electrophoresis
Electrospray ionization
Calorimetry
Drug Carriers
Molecular modeling
Beverages
Dialysis
Size exclusion chromatography
Electrospray Ionization Mass Spectrometry
Fluorescence Spectrometry
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Differential Scanning Calorimetry
Fluorescence spectroscopy
Capillary Electrophoresis

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Clinical Biochemistry

Cite this

Jaldappagari, Seetharamappa ; Balakrishnan, Sandhya ; Hegde, Ashwini H. ; Teradal, Nagappa L. ; Narayan, Prashanth S. / Interactions of polyphenols with plasma proteins : Insights from analytical techniques. In: Current Drug Metabolism. 2013 ; Vol. 14, No. 4. pp. 456-473.
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Interactions of polyphenols with plasma proteins : Insights from analytical techniques. / Jaldappagari, Seetharamappa; Balakrishnan, Sandhya; Hegde, Ashwini H.; Teradal, Nagappa L.; Narayan, Prashanth S.

In: Current Drug Metabolism, Vol. 14, No. 4, 01.05.2013, p. 456-473.

Research output: Contribution to journalArticle

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