Interpenetrating network hydrogel beads of carboxymethylcellulose and egg albumin for controlled release of lipid lowering drug

Rashmi Boppana, Raghavendra V. Kulkarni, Srinivas S. Mutalik, C. Mallikarjun Setty, Biswanath Sa

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Novel interpenetrating network hydrogel beads of sodium carboxymethylcellulose and egg albumin loaded with a lipid lowering drug, simvastatin, were prepared by ionotropic gelation and covalent cross-linking method. The IPN beads were characterized by differential scanning colorimetric analysis, X-ray diffractometry to understand the crystalline nature of the drug after entrapment into IPN matrix. Fourier transform infrared spectroscopy was used to find the chemical stability of drug in the polymer matrix and scanning electron microscopy was performed to study the surface morphology. The ionically cross-linked beads were capable of releasing drug up to 7 h, whereas the drug release was extended up to 12 h in case of dual cross-linked beads. The beads which were prepared with higher concentration of glutaraldehyde released the drug more slowly. The release data were fitted to an empirical equation to determine the transport mechanism, which indicated the non-Fickian trend for drug transport.

Original languageEnglish
Pages (from-to)337-344
Number of pages8
JournalJournal of Microencapsulation
Volume27
Issue number4
DOIs
Publication statusPublished - 2010

Fingerprint

Ionotropic gelation
Colorimetric analysis
Carboxymethylcellulose Sodium
Interpenetrating polymer networks
Hydrogel
eggs
Chemical stability
Polymer matrix
albumins
Hydrogels
beads
X ray diffraction analysis
Lipids
Fourier transform infrared spectroscopy
Surface morphology
Ovum
lipids
Albumins
drugs
Sodium

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry

Cite this

Boppana, Rashmi ; Kulkarni, Raghavendra V. ; Mutalik, Srinivas S. ; Setty, C. Mallikarjun ; Sa, Biswanath. / Interpenetrating network hydrogel beads of carboxymethylcellulose and egg albumin for controlled release of lipid lowering drug. In: Journal of Microencapsulation. 2010 ; Vol. 27, No. 4. pp. 337-344.
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Interpenetrating network hydrogel beads of carboxymethylcellulose and egg albumin for controlled release of lipid lowering drug. / Boppana, Rashmi; Kulkarni, Raghavendra V.; Mutalik, Srinivas S.; Setty, C. Mallikarjun; Sa, Biswanath.

In: Journal of Microencapsulation, Vol. 27, No. 4, 2010, p. 337-344.

Research output: Contribution to journalArticle

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AU - Boppana, Rashmi

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