Interstitial lung disease and neuropathy as predominant extra-articular manifestations in patients with rheumatoid arthritis: A prospective study

Anurag Bharadwaj, Nigil Haroon

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Rheumatoid arthritis (RA) patients with extra-articular manifestations (ExRA) have a severe course of the disease and higher mortality. Indian patients are considered to have a low prevalence of ExRA. We prospectively assessed ExRA in patients with rheumatoid arthritis from southern India. Material/Methods: 140 RA patients were qualified for the study. Patients with confounding factors were excluded. A detailed history and clinical examination was performed. Two independent investigators made a thorough search with relevant investigations for ExRA, according to well-defined criteria. Results: At least one ExRA was present in 36 patients (25.7%). The predominant ExRA (9.29%) was Interstitial Lung Disease (ILD). 12 patients had neuropathy (8.57%). 5 patients had eye involvement, while 3 had cutaneous vasculitis. 4 patients had rheumatoid nodules, and 1 had amyloidosis. The median age at diagnosis and duration of disease were significantly higher in patients with ExRAs than in those without. Deformities and the use of steroids were more common in the ExRA cohort. Conclusions: The present study shows a high prevalence of ILD and neuropathy as ExRAs in our population. A more extensive investigative protocol is warranted for picking up milder presentations of these serious manifestations.

Original languageEnglish
JournalMedical Science Monitor
Volume11
Issue number10
Publication statusPublished - 01-10-2005
Externally publishedYes

Fingerprint

Interstitial Lung Diseases
Rheumatoid Arthritis
Joints
Prospective Studies
Rheumatoid Nodule
Amyloidosis
Vasculitis
India
History
Steroids
Research Personnel
Skin
Mortality

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{77b16c5632c24d80b76dcbbeb6fc1c86,
title = "Interstitial lung disease and neuropathy as predominant extra-articular manifestations in patients with rheumatoid arthritis: A prospective study",
abstract = "Background: Rheumatoid arthritis (RA) patients with extra-articular manifestations (ExRA) have a severe course of the disease and higher mortality. Indian patients are considered to have a low prevalence of ExRA. We prospectively assessed ExRA in patients with rheumatoid arthritis from southern India. Material/Methods: 140 RA patients were qualified for the study. Patients with confounding factors were excluded. A detailed history and clinical examination was performed. Two independent investigators made a thorough search with relevant investigations for ExRA, according to well-defined criteria. Results: At least one ExRA was present in 36 patients (25.7{\%}). The predominant ExRA (9.29{\%}) was Interstitial Lung Disease (ILD). 12 patients had neuropathy (8.57{\%}). 5 patients had eye involvement, while 3 had cutaneous vasculitis. 4 patients had rheumatoid nodules, and 1 had amyloidosis. The median age at diagnosis and duration of disease were significantly higher in patients with ExRAs than in those without. Deformities and the use of steroids were more common in the ExRA cohort. Conclusions: The present study shows a high prevalence of ILD and neuropathy as ExRAs in our population. A more extensive investigative protocol is warranted for picking up milder presentations of these serious manifestations.",
author = "Anurag Bharadwaj and Nigil Haroon",
year = "2005",
month = "10",
day = "1",
language = "English",
volume = "11",
journal = "Medical Science Monitor",
issn = "1234-1010",
publisher = "International Scientific Literature Inc.",
number = "10",

}

Interstitial lung disease and neuropathy as predominant extra-articular manifestations in patients with rheumatoid arthritis : A prospective study. / Bharadwaj, Anurag; Haroon, Nigil.

In: Medical Science Monitor, Vol. 11, No. 10, 01.10.2005.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Interstitial lung disease and neuropathy as predominant extra-articular manifestations in patients with rheumatoid arthritis

T2 - A prospective study

AU - Bharadwaj, Anurag

AU - Haroon, Nigil

PY - 2005/10/1

Y1 - 2005/10/1

N2 - Background: Rheumatoid arthritis (RA) patients with extra-articular manifestations (ExRA) have a severe course of the disease and higher mortality. Indian patients are considered to have a low prevalence of ExRA. We prospectively assessed ExRA in patients with rheumatoid arthritis from southern India. Material/Methods: 140 RA patients were qualified for the study. Patients with confounding factors were excluded. A detailed history and clinical examination was performed. Two independent investigators made a thorough search with relevant investigations for ExRA, according to well-defined criteria. Results: At least one ExRA was present in 36 patients (25.7%). The predominant ExRA (9.29%) was Interstitial Lung Disease (ILD). 12 patients had neuropathy (8.57%). 5 patients had eye involvement, while 3 had cutaneous vasculitis. 4 patients had rheumatoid nodules, and 1 had amyloidosis. The median age at diagnosis and duration of disease were significantly higher in patients with ExRAs than in those without. Deformities and the use of steroids were more common in the ExRA cohort. Conclusions: The present study shows a high prevalence of ILD and neuropathy as ExRAs in our population. A more extensive investigative protocol is warranted for picking up milder presentations of these serious manifestations.

AB - Background: Rheumatoid arthritis (RA) patients with extra-articular manifestations (ExRA) have a severe course of the disease and higher mortality. Indian patients are considered to have a low prevalence of ExRA. We prospectively assessed ExRA in patients with rheumatoid arthritis from southern India. Material/Methods: 140 RA patients were qualified for the study. Patients with confounding factors were excluded. A detailed history and clinical examination was performed. Two independent investigators made a thorough search with relevant investigations for ExRA, according to well-defined criteria. Results: At least one ExRA was present in 36 patients (25.7%). The predominant ExRA (9.29%) was Interstitial Lung Disease (ILD). 12 patients had neuropathy (8.57%). 5 patients had eye involvement, while 3 had cutaneous vasculitis. 4 patients had rheumatoid nodules, and 1 had amyloidosis. The median age at diagnosis and duration of disease were significantly higher in patients with ExRAs than in those without. Deformities and the use of steroids were more common in the ExRA cohort. Conclusions: The present study shows a high prevalence of ILD and neuropathy as ExRAs in our population. A more extensive investigative protocol is warranted for picking up milder presentations of these serious manifestations.

UR - http://www.scopus.com/inward/record.url?scp=26944498645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26944498645&partnerID=8YFLogxK

M3 - Article

C2 - 16192902

AN - SCOPUS:26944498645

VL - 11

JO - Medical Science Monitor

JF - Medical Science Monitor

SN - 1234-1010

IS - 10

ER -