TY - JOUR
T1 - Investigating feasibility of 2021 WHO protocol for cervical cancer screening in underscreened populations
T2 - PREvention and SCReening Innovation Project Toward Elimination of Cervical Cancer (PRESCRIP-TEC)
AU - Sultanov, Marat
AU - Zeeuw, Janine de
AU - Koot, Jaap
AU - der Schans, Jurjen van
AU - Beltman, Jogchum J.
AU - Fouw, Marlieke de
AU - Majdan, Marek
AU - Rusnak, Martin
AU - Nazrul, Naheed
AU - Rahman, Aminur
AU - Nakisige, Carolyn
AU - Rao, Arathi P.
AU - Prasad, Keerthana
AU - Guruvare, Shyamala
AU - Biesma, Regien
AU - Versluis, Marco
AU - de Bock, Geertruida H.
AU - Stekelenburg, Jelle
N1 - Funding Information:
This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 964270. This project is part of the cancer research programme of the Global Alliance for Chronic Diseases (GACD). The EU and GACD have no influence on the design of PRESCRIP-TEC and publications resulting from PRESCRIP-TEC. The project has also received funding from Department of Biotechnology, India under grant agreement 13213 (BT/IN/EU-CoF-GACD/01/KP/2021-22). The Department of Biotechnology requested to include additional study sites in India. The funding body does not have any influence on any other aspect of the design of PRESCRIP-TEC and publications resulting from PRESCRIP-TEC.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Background: High-risk human papillomavirus (hrHPV) testing has been recommended by the World Health Organization as the primary screening test in cervical screening programs. The option of self-sampling for this screening method can potentially increase women’s participation. Designing screening programs to implement this method among underscreened populations will require contextualized evidence. Methods: PREvention and SCReening Innovation Project Toward Elimination of Cervical Cancer (PRESCRIP-TEC) will use a multi-method approach to investigate the feasibility of implementing a cervical cancer screening strategy with hrHPV self-testing as the primary screening test in Bangladesh, India, Slovak Republic and Uganda. The primary outcomes of study include uptake and coverage of the screening program and adherence to follow-up. These outcomes will be evaluated through a pre-post quasi-experimental study design. Secondary objectives of the study include the analysis of client-related factors and health system factors related to cervical cancer screening, a validation study of an artificial intelligence decision support system and an economic evaluation of the screening strategy. Discussion: PRESCRIP-TEC aims to provide evidence regarding hrHPV self-testing and the World Health Organization’s recommendations for cervical cancer screening in a variety of settings, targeting vulnerable groups. The main quantitative findings of the project related to the impact on uptake and coverage of screening will be complemented by qualitative analyses of various determinants of successful implementation of screening. The study will also provide decision-makers with insights into economic aspects of implementing hrHPV self-testing, as well as evaluate the feasibility of using artificial intelligence for task-shifting in visual inspection with acetic acid. Trial registration: ClinicalTrials.gov, NCT05234112. Registered 10 February 2022.
AB - Background: High-risk human papillomavirus (hrHPV) testing has been recommended by the World Health Organization as the primary screening test in cervical screening programs. The option of self-sampling for this screening method can potentially increase women’s participation. Designing screening programs to implement this method among underscreened populations will require contextualized evidence. Methods: PREvention and SCReening Innovation Project Toward Elimination of Cervical Cancer (PRESCRIP-TEC) will use a multi-method approach to investigate the feasibility of implementing a cervical cancer screening strategy with hrHPV self-testing as the primary screening test in Bangladesh, India, Slovak Republic and Uganda. The primary outcomes of study include uptake and coverage of the screening program and adherence to follow-up. These outcomes will be evaluated through a pre-post quasi-experimental study design. Secondary objectives of the study include the analysis of client-related factors and health system factors related to cervical cancer screening, a validation study of an artificial intelligence decision support system and an economic evaluation of the screening strategy. Discussion: PRESCRIP-TEC aims to provide evidence regarding hrHPV self-testing and the World Health Organization’s recommendations for cervical cancer screening in a variety of settings, targeting vulnerable groups. The main quantitative findings of the project related to the impact on uptake and coverage of screening will be complemented by qualitative analyses of various determinants of successful implementation of screening. The study will also provide decision-makers with insights into economic aspects of implementing hrHPV self-testing, as well as evaluate the feasibility of using artificial intelligence for task-shifting in visual inspection with acetic acid. Trial registration: ClinicalTrials.gov, NCT05234112. Registered 10 February 2022.
UR - http://www.scopus.com/inward/record.url?scp=85134256481&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85134256481&partnerID=8YFLogxK
U2 - 10.1186/s12889-022-13488-z
DO - 10.1186/s12889-022-13488-z
M3 - Article
C2 - 35840949
AN - SCOPUS:85134256481
SN - 1471-2458
VL - 22
SP - 1356
JO - BMC Public Health
JF - BMC Public Health
IS - 1
M1 - 1356
ER -
