Investigating the effect of freezing temperature and cross-linking on modulating drug release from chitosan scaffolds

Eshwari Dathathri, Goutam Thakur, K. B. Koteshwara, N. V. Anil Kumar, Fiona Concy Rodrigues

Research output: Contribution to journalArticle

Abstract

The aim of this study was to investigate the effect of altering design variables like cross-linking and freezing temperature (at a time) on morphology of freeze-dried chitosan scaffolds and modulation of release of Diclofenac sodium (model drug). Freeze-dried chitosan scaffolds produced at − 80 °C, cross-linked with genipin, showed swelling of 163.52 ± 9.95% with sustained drug release of 26.37 ± 10.47% over 24 h (P < 0.05). In comparison, uncross-linked scaffolds produced at − 80 °C showed higher swelling of 173.58 ± 8.23% and drug release of 28.67 ± 2.40% (P < 0.05). Uncross-linked scaffolds produced using freezing temperature of − 20 °C also showed higher swelling of 228.77 ± 9.84% and release of 30.58 ± 3.25% (P < 0.05). Release kinetics followed Higuchi model with Fickian diffusion, thereby indicating a swelling-dependent release. Altering the design parameters also showed significant changes in pore size and porosity, thereby supporting the swelling and drug delivery behavior from scaffolds.

Original languageEnglish
JournalChemical Papers
DOIs
Publication statusAccepted/In press - 01-01-2019

Fingerprint

Chitosan
Scaffolds
Freezing
Swelling
Temperature
Diclofenac
Porosity
Pharmaceutical Preparations
Drug delivery
Pore size
Sodium
Modulation
Drug Liberation
Kinetics
genipin

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering
  • Materials Chemistry

Cite this

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title = "Investigating the effect of freezing temperature and cross-linking on modulating drug release from chitosan scaffolds",
abstract = "The aim of this study was to investigate the effect of altering design variables like cross-linking and freezing temperature (at a time) on morphology of freeze-dried chitosan scaffolds and modulation of release of Diclofenac sodium (model drug). Freeze-dried chitosan scaffolds produced at − 80 °C, cross-linked with genipin, showed swelling of 163.52 ± 9.95{\%} with sustained drug release of 26.37 ± 10.47{\%} over 24 h (P < 0.05). In comparison, uncross-linked scaffolds produced at − 80 °C showed higher swelling of 173.58 ± 8.23{\%} and drug release of 28.67 ± 2.40{\%} (P < 0.05). Uncross-linked scaffolds produced using freezing temperature of − 20 °C also showed higher swelling of 228.77 ± 9.84{\%} and release of 30.58 ± 3.25{\%} (P < 0.05). Release kinetics followed Higuchi model with Fickian diffusion, thereby indicating a swelling-dependent release. Altering the design parameters also showed significant changes in pore size and porosity, thereby supporting the swelling and drug delivery behavior from scaffolds.",
author = "Eshwari Dathathri and Goutam Thakur and Koteshwara, {K. B.} and {Anil Kumar}, {N. V.} and Rodrigues, {Fiona Concy}",
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AU - Dathathri, Eshwari

AU - Thakur, Goutam

AU - Koteshwara, K. B.

AU - Anil Kumar, N. V.

AU - Rodrigues, Fiona Concy

PY - 2019/1/1

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N2 - The aim of this study was to investigate the effect of altering design variables like cross-linking and freezing temperature (at a time) on morphology of freeze-dried chitosan scaffolds and modulation of release of Diclofenac sodium (model drug). Freeze-dried chitosan scaffolds produced at − 80 °C, cross-linked with genipin, showed swelling of 163.52 ± 9.95% with sustained drug release of 26.37 ± 10.47% over 24 h (P < 0.05). In comparison, uncross-linked scaffolds produced at − 80 °C showed higher swelling of 173.58 ± 8.23% and drug release of 28.67 ± 2.40% (P < 0.05). Uncross-linked scaffolds produced using freezing temperature of − 20 °C also showed higher swelling of 228.77 ± 9.84% and release of 30.58 ± 3.25% (P < 0.05). Release kinetics followed Higuchi model with Fickian diffusion, thereby indicating a swelling-dependent release. Altering the design parameters also showed significant changes in pore size and porosity, thereby supporting the swelling and drug delivery behavior from scaffolds.

AB - The aim of this study was to investigate the effect of altering design variables like cross-linking and freezing temperature (at a time) on morphology of freeze-dried chitosan scaffolds and modulation of release of Diclofenac sodium (model drug). Freeze-dried chitosan scaffolds produced at − 80 °C, cross-linked with genipin, showed swelling of 163.52 ± 9.95% with sustained drug release of 26.37 ± 10.47% over 24 h (P < 0.05). In comparison, uncross-linked scaffolds produced at − 80 °C showed higher swelling of 173.58 ± 8.23% and drug release of 28.67 ± 2.40% (P < 0.05). Uncross-linked scaffolds produced using freezing temperature of − 20 °C also showed higher swelling of 228.77 ± 9.84% and release of 30.58 ± 3.25% (P < 0.05). Release kinetics followed Higuchi model with Fickian diffusion, thereby indicating a swelling-dependent release. Altering the design parameters also showed significant changes in pore size and porosity, thereby supporting the swelling and drug delivery behavior from scaffolds.

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