Investigation of anti-inflammatory potentials of Terminalia tomentosa Wight & Arn. Bark - An in-vitro approach

Jitta Srinivasa Reddy, Lobo Richard, Daram Prasanthi, C. S. Shreedhara, Aravinda Pai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Terminalia tomentosa bark. Belongs to the family Combretaceae. Bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis and diarrhea.This study establish the antiinflammatory activity of ethanolic (TEA) and aqueous (TEW) of T. tormentors aback extracts in in-vitro methods by Inhibition protein denaturation (BSA),Inhibition of Egg Albumin denaturationand The human HRBC membrane stabilization method., alcoholic and aqueous extracts exhibited significant protein denaturation inhibition in egg albumin assay with IC50 values TEA113μg/mL, TEW 112.67μg/mL in comparison with Standard (Diclofenac sodium) 236.7μg/ml. In bovine serum albumin denaturation assay with IC50 values TEA 16.91μg/mL and TEW 17.67μg/mL respectively when compared with standard (Diclofenac sodium) 67.21μg/mL. Both alcoholic and aqueous extracts were shown to have membrane stabilization properties with the IC50 values TEA 92.95μg/mL, TEW 37.68μg/mL respectively, in comparison with standard (Diclofenac sodium) 47.48μg/mLTo conclude, this study shows that the T. tormentors, possess significant anti-inflammatory activity.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalJournal of Global Pharma Technology
Volume9
Issue number8
Publication statusPublished - 2017

Fingerprint

Terminalia
Diclofenac
Inhibitory Concentration 50
Protein Denaturation
Anti-Inflammatory Agents
Ovum
Albumins
Combretaceae
Astringents
Membranes
Bronchitis
Bovine Serum Albumin
Ulcer
Diarrhea
Hemorrhage
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

@article{5c44c1f831ff4c318fa68b45972bf5ee,
title = "Investigation of anti-inflammatory potentials of Terminalia tomentosa Wight & Arn. Bark - An in-vitro approach",
abstract = "Terminalia tomentosa bark. Belongs to the family Combretaceae. Bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis and diarrhea.This study establish the antiinflammatory activity of ethanolic (TEA) and aqueous (TEW) of T. tormentors aback extracts in in-vitro methods by Inhibition protein denaturation (BSA),Inhibition of Egg Albumin denaturationand The human HRBC membrane stabilization method., alcoholic and aqueous extracts exhibited significant protein denaturation inhibition in egg albumin assay with IC50 values TEA113μg/mL, TEW 112.67μg/mL in comparison with Standard (Diclofenac sodium) 236.7μg/ml. In bovine serum albumin denaturation assay with IC50 values TEA 16.91μg/mL and TEW 17.67μg/mL respectively when compared with standard (Diclofenac sodium) 67.21μg/mL. Both alcoholic and aqueous extracts were shown to have membrane stabilization properties with the IC50 values TEA 92.95μg/mL, TEW 37.68μg/mL respectively, in comparison with standard (Diclofenac sodium) 47.48μg/mLTo conclude, this study shows that the T. tormentors, possess significant anti-inflammatory activity.",
author = "Reddy, {Jitta Srinivasa} and Lobo Richard and Daram Prasanthi and Shreedhara, {C. S.} and Aravinda Pai",
note = "cited By 0",
year = "2017",
language = "English",
volume = "9",
pages = "1--5",
journal = "Journal of Global Pharma Technology",
issn = "0975-8542",
publisher = "Journal of Global Pharma Technology",
number = "8",

}

Investigation of anti-inflammatory potentials of Terminalia tomentosa Wight & Arn. Bark - An in-vitro approach. / Reddy, Jitta Srinivasa; Richard, Lobo; Prasanthi, Daram; Shreedhara, C. S.; Pai, Aravinda.

In: Journal of Global Pharma Technology, Vol. 9, No. 8, 2017, p. 1-5.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Investigation of anti-inflammatory potentials of Terminalia tomentosa Wight & Arn. Bark - An in-vitro approach

AU - Reddy, Jitta Srinivasa

AU - Richard, Lobo

AU - Prasanthi, Daram

AU - Shreedhara, C. S.

AU - Pai, Aravinda

N1 - cited By 0

PY - 2017

Y1 - 2017

N2 - Terminalia tomentosa bark. Belongs to the family Combretaceae. Bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis and diarrhea.This study establish the antiinflammatory activity of ethanolic (TEA) and aqueous (TEW) of T. tormentors aback extracts in in-vitro methods by Inhibition protein denaturation (BSA),Inhibition of Egg Albumin denaturationand The human HRBC membrane stabilization method., alcoholic and aqueous extracts exhibited significant protein denaturation inhibition in egg albumin assay with IC50 values TEA113μg/mL, TEW 112.67μg/mL in comparison with Standard (Diclofenac sodium) 236.7μg/ml. In bovine serum albumin denaturation assay with IC50 values TEA 16.91μg/mL and TEW 17.67μg/mL respectively when compared with standard (Diclofenac sodium) 67.21μg/mL. Both alcoholic and aqueous extracts were shown to have membrane stabilization properties with the IC50 values TEA 92.95μg/mL, TEW 37.68μg/mL respectively, in comparison with standard (Diclofenac sodium) 47.48μg/mLTo conclude, this study shows that the T. tormentors, possess significant anti-inflammatory activity.

AB - Terminalia tomentosa bark. Belongs to the family Combretaceae. Bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis and diarrhea.This study establish the antiinflammatory activity of ethanolic (TEA) and aqueous (TEW) of T. tormentors aback extracts in in-vitro methods by Inhibition protein denaturation (BSA),Inhibition of Egg Albumin denaturationand The human HRBC membrane stabilization method., alcoholic and aqueous extracts exhibited significant protein denaturation inhibition in egg albumin assay with IC50 values TEA113μg/mL, TEW 112.67μg/mL in comparison with Standard (Diclofenac sodium) 236.7μg/ml. In bovine serum albumin denaturation assay with IC50 values TEA 16.91μg/mL and TEW 17.67μg/mL respectively when compared with standard (Diclofenac sodium) 67.21μg/mL. Both alcoholic and aqueous extracts were shown to have membrane stabilization properties with the IC50 values TEA 92.95μg/mL, TEW 37.68μg/mL respectively, in comparison with standard (Diclofenac sodium) 47.48μg/mLTo conclude, this study shows that the T. tormentors, possess significant anti-inflammatory activity.

UR - http://www.scopus.com/inward/record.url?scp=85031931101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031931101&partnerID=8YFLogxK

M3 - Article

VL - 9

SP - 1

EP - 5

JO - Journal of Global Pharma Technology

JF - Journal of Global Pharma Technology

SN - 0975-8542

IS - 8

ER -