Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-Induced inflammatory bowel disorder in albino rats

P. K. Kondamudi, Hemalatha Kovelamudi, Geetha Mathew, Pawan G. Nayak, Mallikarjuna C. Rao, Rekha R. Shenoy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats. Methods.The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed. Results. The levels of MPO, TBARS, and tissue nitrite increased significantly ( < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. Conclusions.The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

Original languageEnglish
Article number673248
JournalThe Scientific World Journal
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Acetic Acid
acetic acid
Peroxidase
nitrite
Rats
Colon
Nitrites
Inflammatory Bowel Diseases
Sulfasalazine
Sesame Oil
serum
Gastrointestinal Tract
oil
Tissue
sesamol
Serum
effect
evaluation
method
tissue

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

Cite this

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title = "Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-Induced inflammatory bowel disorder in albino rats",
abstract = "Background. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats. Methods.The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed. Results. The levels of MPO, TBARS, and tissue nitrite increased significantly ( < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. Conclusions.The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.",
author = "Kondamudi, {P. K.} and Hemalatha Kovelamudi and Geetha Mathew and Nayak, {Pawan G.} and Rao, {Mallikarjuna C.} and Shenoy, {Rekha R.}",
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Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-Induced inflammatory bowel disorder in albino rats. / Kondamudi, P. K.; Kovelamudi, Hemalatha; Mathew, Geetha; Nayak, Pawan G.; Rao, Mallikarjuna C.; Shenoy, Rekha R.

In: The Scientific World Journal, Vol. 2014, 673248, 2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-Induced inflammatory bowel disorder in albino rats

AU - Kondamudi, P. K.

AU - Kovelamudi, Hemalatha

AU - Mathew, Geetha

AU - Nayak, Pawan G.

AU - Rao, Mallikarjuna C.

AU - Shenoy, Rekha R.

PY - 2014

Y1 - 2014

N2 - Background. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats. Methods.The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed. Results. The levels of MPO, TBARS, and tissue nitrite increased significantly ( < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. Conclusions.The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

AB - Background. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats. Methods.The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed. Results. The levels of MPO, TBARS, and tissue nitrite increased significantly ( < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. Conclusions.The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.

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