Ionic gelation controlled drug delivery systems for gastric-mucoadhesive microcapsules of captopril

M. Altaf, Sreedharan, N. Charyulu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A new oral drug delivery system was developed utilizing both the concepts of controlled release and mucoadhesiveness, in order to obtain a unique drug delivery system which could remain in stomach and control the drug release for longer period of time. Captopril microcapsules were prepared with a coat consisting of alginate and a mucoadhesive polymer such as hydroxy propyl methyl cellulose, carbopol 934p, chitosan and cellulose acetate phthalate using emulsification ionic gelation process. The resulting microcapsules were discrete, large, spherical and free flowing. Microencapsulation efficiency was 41.7-89.7% and high percentage efficiency was observed with (9:1) alginate-chitosan microcapsules. All alginate-carbopol 934p microcapsules exhibited good mucoadhesive property in the in vitro wash off test. Drug release pattern for all formulation in 0.1 N HCl (pH 1.2) was diffusion controlled, gradually over 8 h and followed zero order kinetics.

Original languageEnglish
Pages (from-to)655-658
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume70
Issue number5
DOIs
Publication statusPublished - 01-02-2008

Fingerprint

Captopril
Drug Delivery Systems
Capsules
Stomach
Chitosan
Drug Compounding
Methylcellulose
Polymers
alginic acid
Drug Liberation
carbopol 934P

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

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Ionic gelation controlled drug delivery systems for gastric-mucoadhesive microcapsules of captopril. / Altaf, M.; Sreedharan; Charyulu, N.

In: Indian Journal of Pharmaceutical Sciences, Vol. 70, No. 5, 01.02.2008, p. 655-658.

Research output: Contribution to journalArticle

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