Iron sucrose versus oral iron therapy in pregnancy anemia

Syal Neeru, N. Sreekumaran Nair, Lavanya Rai

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Iron deficiency anemia (IDA) is the most common medical problem in pregnancy. Parenteral iron is a useful treatment, although iron dextran use decreased due to anaphylaxis. Iron sucrose is a newer agent that has overcome the shortcomings of iron dextran. Objective: The aim of this study was to compare the efficacy and tolerance of intravenous iron sucrose (IVIS) therapy with oral iron (OI) therapy in pregnant women with IDA and to study the factors influencing treatment. Materials and Methods: This prospective, randomized clinical trial included pregnant women between 14 and 36 weeks with established IDA who were treated with IVIS or OI (ferrous fumarate). All patients were monitored for laboratory response and adverse effects. Independent sample-t test, Chi square test and ANOVA were used for statistical analysis. P < 0.05 was considered significant. Results: Although hemoglobin increased in both the groups, increase in the reticulocyte count and percentage increase in hemoglobin was significantly higher in the IVIS group than in the OI group (23.62% vs. 14.11%). Serum ferritin was significantly higher in the IVIS group than in the OI group (P = 0.000). The IVIS group had no major side-effects. Compliance was good with OI, although 23% had gastrointestinal side-effects. Patient weight, gestation at diagnosis, initial hemoglobin and ferritin levels did not influence the response to treatment. Conclusion: IVIS is safe and effective in the treatment of IDA during pregnancy. Iron stores increased better with IVIS compared with OI.

Original languageEnglish
Pages (from-to)214-218
Number of pages5
JournalIndian Journal of Community Medicine
Volume37
Issue number4
DOIs
Publication statusPublished - 01-10-2012

Fingerprint

saccharated ferric oxide
Anemia
Iron
Pregnancy
Iron-Deficiency Anemias
Therapeutics
Hemoglobins
Ferritins
Dextrans
Pregnant Women
Reticulocyte Count

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Neeru, Syal ; Nair, N. Sreekumaran ; Rai, Lavanya. / Iron sucrose versus oral iron therapy in pregnancy anemia. In: Indian Journal of Community Medicine. 2012 ; Vol. 37, No. 4. pp. 214-218.
@article{605891c023c04ef4b2aa7f701e384a53,
title = "Iron sucrose versus oral iron therapy in pregnancy anemia",
abstract = "Background: Iron deficiency anemia (IDA) is the most common medical problem in pregnancy. Parenteral iron is a useful treatment, although iron dextran use decreased due to anaphylaxis. Iron sucrose is a newer agent that has overcome the shortcomings of iron dextran. Objective: The aim of this study was to compare the efficacy and tolerance of intravenous iron sucrose (IVIS) therapy with oral iron (OI) therapy in pregnant women with IDA and to study the factors influencing treatment. Materials and Methods: This prospective, randomized clinical trial included pregnant women between 14 and 36 weeks with established IDA who were treated with IVIS or OI (ferrous fumarate). All patients were monitored for laboratory response and adverse effects. Independent sample-t test, Chi square test and ANOVA were used for statistical analysis. P < 0.05 was considered significant. Results: Although hemoglobin increased in both the groups, increase in the reticulocyte count and percentage increase in hemoglobin was significantly higher in the IVIS group than in the OI group (23.62{\%} vs. 14.11{\%}). Serum ferritin was significantly higher in the IVIS group than in the OI group (P = 0.000). The IVIS group had no major side-effects. Compliance was good with OI, although 23{\%} had gastrointestinal side-effects. Patient weight, gestation at diagnosis, initial hemoglobin and ferritin levels did not influence the response to treatment. Conclusion: IVIS is safe and effective in the treatment of IDA during pregnancy. Iron stores increased better with IVIS compared with OI.",
author = "Syal Neeru and Nair, {N. Sreekumaran} and Lavanya Rai",
year = "2012",
month = "10",
day = "1",
doi = "10.4103/0970-0218.103467",
language = "English",
volume = "37",
pages = "214--218",
journal = "Indian Journal of Community Medicine",
issn = "0970-0218",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "4",

}

Iron sucrose versus oral iron therapy in pregnancy anemia. / Neeru, Syal; Nair, N. Sreekumaran; Rai, Lavanya.

In: Indian Journal of Community Medicine, Vol. 37, No. 4, 01.10.2012, p. 214-218.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Iron sucrose versus oral iron therapy in pregnancy anemia

AU - Neeru, Syal

AU - Nair, N. Sreekumaran

AU - Rai, Lavanya

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Background: Iron deficiency anemia (IDA) is the most common medical problem in pregnancy. Parenteral iron is a useful treatment, although iron dextran use decreased due to anaphylaxis. Iron sucrose is a newer agent that has overcome the shortcomings of iron dextran. Objective: The aim of this study was to compare the efficacy and tolerance of intravenous iron sucrose (IVIS) therapy with oral iron (OI) therapy in pregnant women with IDA and to study the factors influencing treatment. Materials and Methods: This prospective, randomized clinical trial included pregnant women between 14 and 36 weeks with established IDA who were treated with IVIS or OI (ferrous fumarate). All patients were monitored for laboratory response and adverse effects. Independent sample-t test, Chi square test and ANOVA were used for statistical analysis. P < 0.05 was considered significant. Results: Although hemoglobin increased in both the groups, increase in the reticulocyte count and percentage increase in hemoglobin was significantly higher in the IVIS group than in the OI group (23.62% vs. 14.11%). Serum ferritin was significantly higher in the IVIS group than in the OI group (P = 0.000). The IVIS group had no major side-effects. Compliance was good with OI, although 23% had gastrointestinal side-effects. Patient weight, gestation at diagnosis, initial hemoglobin and ferritin levels did not influence the response to treatment. Conclusion: IVIS is safe and effective in the treatment of IDA during pregnancy. Iron stores increased better with IVIS compared with OI.

AB - Background: Iron deficiency anemia (IDA) is the most common medical problem in pregnancy. Parenteral iron is a useful treatment, although iron dextran use decreased due to anaphylaxis. Iron sucrose is a newer agent that has overcome the shortcomings of iron dextran. Objective: The aim of this study was to compare the efficacy and tolerance of intravenous iron sucrose (IVIS) therapy with oral iron (OI) therapy in pregnant women with IDA and to study the factors influencing treatment. Materials and Methods: This prospective, randomized clinical trial included pregnant women between 14 and 36 weeks with established IDA who were treated with IVIS or OI (ferrous fumarate). All patients were monitored for laboratory response and adverse effects. Independent sample-t test, Chi square test and ANOVA were used for statistical analysis. P < 0.05 was considered significant. Results: Although hemoglobin increased in both the groups, increase in the reticulocyte count and percentage increase in hemoglobin was significantly higher in the IVIS group than in the OI group (23.62% vs. 14.11%). Serum ferritin was significantly higher in the IVIS group than in the OI group (P = 0.000). The IVIS group had no major side-effects. Compliance was good with OI, although 23% had gastrointestinal side-effects. Patient weight, gestation at diagnosis, initial hemoglobin and ferritin levels did not influence the response to treatment. Conclusion: IVIS is safe and effective in the treatment of IDA during pregnancy. Iron stores increased better with IVIS compared with OI.

UR - http://www.scopus.com/inward/record.url?scp=84870257637&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870257637&partnerID=8YFLogxK

U2 - 10.4103/0970-0218.103467

DO - 10.4103/0970-0218.103467

M3 - Article

VL - 37

SP - 214

EP - 218

JO - Indian Journal of Community Medicine

JF - Indian Journal of Community Medicine

SN - 0970-0218

IS - 4

ER -