Abstract
Background: Amlodipine, a dihydropyridine calcium channel blocker (CCB) is commonly prescribed for cardiovascular conditions. Its administration may produce an uncommon adverse oral manifestation, the gingival overgrowth (GO). Lately, there has been an increase in the rate of GO in patients on amlodipine therapy. The current systematic review was undertaken to evaluate the evidence on plausible risk factors involved in amlodipine induced gingival overgrowth (AIGO). Material and Methods: Literature search was conducted in the databases like Pubmed (Medline), Scopus and Google Scholar to include the original research articles related to etio-pathogenesis of AIGO. Results: About 270 documents were identified through primary search, of which 13 original research articles were included. Most common risk factor for AIGO was administration of amlodipine in subjects with poor plaque control. However, high dosage of drug, duration of therapy and inherent genetic susceptibility were recognized as other plausible risk factors. Conclusions: It was concluded that AIGO is no longer a rare phenomenon. It is therefore imperative for the physician to identify and inform patients, about the risk factors associated with the overgrowth at the initiation of therapy. This would prevent the development of GO's and improve the patient's quality of life.
| Original language | English |
|---|---|
| Pages (from-to) | e610-e619 |
| Journal | Journal of Clinical and Experimental Dentistry |
| Volume | 10 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 01-06-2018 |
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All Science Journal Classification (ASJC) codes
- Dentistry(all)
Cite this
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Is dental plaque the only etiological factor in Amlodipine induced gingival overgrowth? A systematic review of evidence. / Gaur, Sumit; Agnihotri, Rupali.
In: Journal of Clinical and Experimental Dentistry, Vol. 10, No. 6, 01.06.2018, p. e610-e619.Research output: Contribution to journal › Article
TY - JOUR
T1 - Is dental plaque the only etiological factor in Amlodipine induced gingival overgrowth? A systematic review of evidence
AU - Gaur, Sumit
AU - Agnihotri, Rupali
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Background: Amlodipine, a dihydropyridine calcium channel blocker (CCB) is commonly prescribed for cardiovascular conditions. Its administration may produce an uncommon adverse oral manifestation, the gingival overgrowth (GO). Lately, there has been an increase in the rate of GO in patients on amlodipine therapy. The current systematic review was undertaken to evaluate the evidence on plausible risk factors involved in amlodipine induced gingival overgrowth (AIGO). Material and Methods: Literature search was conducted in the databases like Pubmed (Medline), Scopus and Google Scholar to include the original research articles related to etio-pathogenesis of AIGO. Results: About 270 documents were identified through primary search, of which 13 original research articles were included. Most common risk factor for AIGO was administration of amlodipine in subjects with poor plaque control. However, high dosage of drug, duration of therapy and inherent genetic susceptibility were recognized as other plausible risk factors. Conclusions: It was concluded that AIGO is no longer a rare phenomenon. It is therefore imperative for the physician to identify and inform patients, about the risk factors associated with the overgrowth at the initiation of therapy. This would prevent the development of GO's and improve the patient's quality of life.
AB - Background: Amlodipine, a dihydropyridine calcium channel blocker (CCB) is commonly prescribed for cardiovascular conditions. Its administration may produce an uncommon adverse oral manifestation, the gingival overgrowth (GO). Lately, there has been an increase in the rate of GO in patients on amlodipine therapy. The current systematic review was undertaken to evaluate the evidence on plausible risk factors involved in amlodipine induced gingival overgrowth (AIGO). Material and Methods: Literature search was conducted in the databases like Pubmed (Medline), Scopus and Google Scholar to include the original research articles related to etio-pathogenesis of AIGO. Results: About 270 documents were identified through primary search, of which 13 original research articles were included. Most common risk factor for AIGO was administration of amlodipine in subjects with poor plaque control. However, high dosage of drug, duration of therapy and inherent genetic susceptibility were recognized as other plausible risk factors. Conclusions: It was concluded that AIGO is no longer a rare phenomenon. It is therefore imperative for the physician to identify and inform patients, about the risk factors associated with the overgrowth at the initiation of therapy. This would prevent the development of GO's and improve the patient's quality of life.
UR - http://www.scopus.com/inward/record.url?scp=85048006965&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048006965&partnerID=8YFLogxK
U2 - 10.4317/jced.54715
DO - 10.4317/jced.54715
M3 - Article
AN - SCOPUS:85048006965
VL - 10
SP - e610-e619
JO - Journal of Clinical and Experimental Dentistry
JF - Journal of Clinical and Experimental Dentistry
SN - 1989-5488
IS - 6
ER -